Our laboratory investigates the mechanisms that regulate nutrient and energy metabolism in cells, tissues, and organisms. We focus on elucidating how the metabolic properties of tissues are specified during development and reprogrammed in disease, dissecting the genetic and epigenetic mechanisms of metabolic regulation, and discovering novel secreted factors in systemic metabolic crosstalk.
- Obesity-associated metabolic disease
- Signaling and gene transcription
- Metabolic tissue development
Jiandie Lin studies the signaling networks that control the storage and utilization of energy in cells and organisms, and how they contribute to obesity, diabetes, and cardiovascular disease.
Guo L, Zhang P, Chen Z, Xia H, Li S, Zhang Y, Kobberup S, Zou W, Lin JD (2017) Hepatic Nrg4 signaling defines an endocrine checkpoint for steatosis-to-NASH progression. Journal of Clinical Investigation, 127:4449-4461
Li S, Mi L, Yu L, Yu Q, Liu T, Wang GX, Zhao XY, Wu J, Lin JD (2017) Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis. Proc Natl Acad Sci USA, 114:E7111-E7120
Meng ZX, Gond J, Chen Z, Sun J, Xiao Y, Wang L, Li Y, Liu J, Xu XZS, and Lin JD (2017) Glucose sensing by skeletal myocytes couples nutrient signaling to systemic homeostasis. Molecular Cell, 66:332-344