David Ginsburg

Our Research

Precise control of the blood-clotting system is essential for maintenance of the circulation in all higher animals. Deficient function of this system can lead to fatal bleeding following even a minor injury, whereas overactivity of this system can produce unwanted blood clots, resulting in blockages to critical blood vessels, as occurs in such diseases as heart attack and stroke.

We study the molecular genetics of blood clotting, specifically von Willebrand factor, coagulation factor V and plasminogen activation.

About David Ginsburg

  • Hematology
  • Blood clotting
  • Genetics

David Ginsburg investigates the components of the blood-clotting system and how disturbances in their function lead to human bleeding and blood-clotting disorders. He studies families with bleeding disorders like hemophilia, to understand the genes and biomolecules that control the blood-clotting response, stroke and heart disease.

Research Highlight: PCSK9

The Ginsburg lab identified a new potential therapeutic target for lowering cholesterol that could be an alternative or complementary therapy to statins like Lipitor.

The scientists inhibited the action of a gene, SEC24A, responsible for transporting a protein, PCSK9, that interferes with the liver's ability to remove cholesterol from the blood in mice. Initial studies of anti-PCSK9 therapies in humans have shown that eliminating PCSK9 can lower cholesterol dramatically. The research points to a new area for study: rather than inhibiting PCSK9 itself, future therapies could block the SEC24A transport mechanism. The research was published April 9 in eLife.

Recent Publications

Baines A.C., Adams E.J., Zhang B., Ginsburg D. (2013). Disruption of the Sec24d Gene Results in Early Embryonic Lethality in the Mouse. PLoS ONE 8(4).

Desch K.C., Ozel A.B., Siemieniak D., Kalish Y., Shavit J.A., Thornburg C.D., Sharathkumar A.A., McHugh C.P., Laurie C.C., Crenshaw A., Mirel D.B., Kim Y., Cropp C.D., Molloy A.M., Kirke P.N., Bailey-Wilson J.E., Wilson A.F., Mills J.L., Scott J.M., Brody L.C., Lib J.Z., Ginsburg D. (2013). Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association. Proceedings of the National Academy of Sciences of the United States of America 110(2):588-593.