Yamashita lab: Clues to understanding how stem cells produce different kinds of cells
May 5, 2013 - Divide and define: Clues to understanding how stem cells produce different kinds of cells
ANN ARBOR—The human body contains trillions of cells, all derived from a single cell, or zygote, made by the fusion of an egg and a sperm. That singl... Learn more...
Inoki lab: Understanding how cells switch between anabolic and catabolic states
April 25, 2013 - Understanding how cells switch between anabolic and catabolic states
University of Michigan researchers have illuminated a critical transaction involved with the way cells sense and regulate energy, pointing the way toward possible new therapeutics ... Learn more...
Ginsburg lab: Targeting the transport mechanism for a destructive protein lowers blood cholesterol levels in mice
April 10, 2013 - Targeting the transport mechanism for a destructive protein lowers blood cholesterol levels in mice
Researchers at the University of Michigan have identified a new potential therapeutic target for lowering cholesterol that could be an alternative or... Learn more...
Lin lab: Lift weights to lower blood sugar? White muscle helps keep blood glucose levels under control
April 8, 2013 - Lift weights to lower blood sugar?
White muscle helps keep blood glucose levels under control
Researchers in the Life Sciences Institute at the University of Michigan have challenged a long-held belief that whitening of skeletal muscle in diabe... Learn more...
Lim lab: Green tea extract interferes with the formation of amyloid plaques in Alzheimer’s disease
March 5, 2013 - Green tea extract interferes with the formation of amyloid plaques in Alzheimer’s disease
Researchers at the University of Michigan have found a new potential benefit of a molecule in green tea: preventing the misfolding of specific pr... Learn more...
Maillard lab examines role of the Notch signalling pathway in graft-versus-host disease
March 1, 2013 - A better bone marrow transplant: Preventing graft-versus-host disease
Bone marrow transplant is a key treatment for patients with leukemia, lymphoma, multiple myeloma and other blood disorders. University of Michigan researchers have discovered that... Learn more...
Stay cool and live longer? Xu lab finds genetic program that promotes roundworm longevity
February 14, 2013 - Stay cool and live longer?
Xu lab identifies a genetic program that promotes longevity of roundworms in cold environments—and this genetic program also exists in warm-blooded animals, including humans.
ANN ARBOR—Scientists have know... Learn more...
Saltiel lab: Old drug may point the way to new treatments for diabetes and obesity
February 6, 2013 - Old drug may point the way to new treatments for diabetes and obesity
ANN ARBOR — Researchers at the University of Michigan’s Life Sciences Institute have found that amlexanox, an off-patent drug currently prescribed for the treatment o... Learn more...
Tesmer lab determines full-length structure of a cardiovascular protein
February 5, 2013 -
Tesmer lab determines full-length structure of a cardiovascular protein
Researchers at the Life Sciences Institute (LSI) have illustrated how a protein activates an enzyme in heart cells in response to a hormonal stimulus. These interactions... Learn more...
Blood brothers (and sisters): U-M sibling study leads to discovery of genetic region linked to control of blood-clotting protein
January 4, 2013 - Blood brothers (and sisters): U-M sibling study leads to discovery of genetic region linked to control of blood-clotting protein
In 2006, the lab of Dr. David Ginsburg at the Life Sciences Institute (LSI) put a call out for siblings attending the Un... Learn more...
Smith lab details how a family of viruses evades detection by the immune system
November 5, 2012 - Stealth virus: How a family of viruses escapes detection by the body’s immune system
ANN ARBOR, Mich. — Researchers in the Life Sciences Institute at the University of Michigan have discovered how a particular type of virus hides and p... Learn more...
Skiniotis lab creates image of leptin receptor structure
October 12, 2012 - Press release: Target for obesity drugs comes into focus
ANN ARBOR—Researchers at the University of Michigan have determined how the hormone leptin, an important regulator of metabolism and body weight, interacts with a key receptor in... Learn more...
The antidepressant Paxil might also prevent heart failure, Tesmer lab finds
September 28, 2012 - The antidepressant Paxil might also prevent heart failure, Tesmer lab finds
A medication usually used to help treat depression and anxiety disorders has the potential to help prevent heart failure, according to research published recently by the lab... Learn more...
Aptamer Attraction: Targeting proteins with precision to improve drug discovery
June 21, 2012 - Aptamer Attraction: Targeting proteins with precision to improve drug discovery
University of Michigan researchers have discovered how a synthetic inhibitor binds to an enzyme involved in heart failure.
Researchers in the lab of John Tesmer, a Prof... Learn more...
