CCG Publications

Publications Archive 2007-2014

Recent Publications

2017

Burrer CM, Auburn H, Wang X, Luo J, Abulwerdi FA, Nikolovska-Coleska Z, Chan GC. Mcl-1 small-molecule inhibitors encapsulated into nanoparticles exhibit increased killing efficacy towards HCMV-infected monocytes. Antiviral Research 2017 138:40-46. doi: 10.1016/j.antiviral.2016.11.027

Chen Y, Liu X, Wu N, Fierke CA. Fluorescence-based real-time activity assays to identify RNase P inhibitors. Methods in Molecular Biology 2017 1520:201-225. doi: 10.1007/978-1-4939-6634-9_12

Dahl J-U, Gray MJ, Bazopoulou D, Beaufay F, Lempart J, Koenigsknecht MJ, Wang Y, Baker JR, Hasler WL, Young VB, Sun D, Jakob U. The anti-inflammatory drug mesalamine targets bacterial polyphosphate accumulation. Nature Microbiology 2017 2(16267). DOI: 10.1038/nmicrobiol.2016.267

Grimley E, Liao C, Ranghini EJ, Nikolovska-Coleska Z, Dressler GR. Inhibition of Pax2 Transcription Activation with a Small Molecule that Targets the DNA Binding Domain. ACS Chemical Biology 2017 12(3):724-734. DOI: 10.18632/oncotarget.13444

Hernandez JL, Davda D, Cheung See Kit M, Majmudar JD, Won SJ, Gang M, Pasupuleti SC, Choi AI, Bartkowiak CM, Martin BR. APT2 Inhibition Restores Scribble Localization and S-Palmitoylation in Snail-Transformed Cells. Cell Chemical Biology 2017 24(1):87-97. DOI: 10.1016/j.chembiol.2016.12.007

Hutchings KM, Lisabeth EM, Rajeswaran W, Wilson MW, Sorenson RJ, Campbell PL, Ruth JH, Amin A, Tsou P-S, Leipprandt JR, Olson SR, Wen B, Zhao T, Sun D, Khanna D, Fox DA, Neubig RR, Larsen SD. Pharmacokinetic optimitzation of CCG-203971: Novel inhibitors of the Rho/MRTF/SRF transcriptional pathway as potential antifibrotic therapeutics for systemic scleroderma. Bioorganic and Medicinal Chemistry Letters 2017 27(8):1744-1749. DOI: 10.1016/j.bmcl.2017.02.070

Joiner CM, Breen ME, Clayton J, Mapp AK. A Bifunctional Amino Acid Enables Both Covalent Chemical Capture and Isolation of in Vivo Protein-Protein Interactions. Chembiochem 2017 18(2):181-184. doi: 10.1002/cbic.201600578.

Lorenz D, Vander Roest S, Larsen M, Garner A. Development and Implementation of an HTS-Compatible Assay for the Discoveyr of Selective Small-Molecule Ligands for Pre-microRNAs. SLAS Discovery 2017. doi: 10.1177/2472555217717944

Metzger BPH, Wittkopp PJ, Coolon JD. Evolutionary Dynamics of Regulatory Changes Underlying Gene Expression Divergence among Saccharomyces Species. Genome Biol Evol 2017 9(4):843-854. doi: 10.1093/gbe/evx035

Ouimet CM, Damico CI, Kennedy RT. Advances in capillary electrophoresis and the implications for drug discovery. Expert Opinion on Drug Discovery 2017 12(2):213-224. DOI: 10.1080/17460441.2017.1268121

Svoboda LK, Bailey N, Van Noord RA, Krook MA, Harris A, Cramer C, Jasman B, Patel RM, Thomas D, Borkin D, Cierpicki T, Grembecka J, Lawlor ER. Tumorigenicity of Ewing sarcoma is critically dependent on the trithorax proteins MLL1 and menin. Oncotarget 2017 8(1):458-471. DOI: 10.18632/oncotarget.13444

Tong J, Wang P, Tan S, Chen D, Nikolovska-Coleska Z, Zou F, Yu J, Zhang L. Mcl-1 degradation is required for targeted therapeutics to eradicate colon cancer cells. Cancer Research 2017 77(9):2512-2521. Doi: 10.1158/0008-5472.CAN-16-3242

Waldschmidt HV, Homan KT, Cato MC, Cruz-Rodri­guez O, Cannavo A, Wilson MW, Song J, Cheung JY, Koch WJ, Tesmer JJG, Larsen SD. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. Journal of Medicinal Chemistry 2017 60(7):3052-3069. DOI: 10.1021/acs.jmedchem.7b00112

2016

Borkin D, Pollock J, Kempinska K, Purohit T, Li X, Wen B., Zhao T, Miao H, Shukla S, He M, Sun D, Cierpicki T, Grembecka J. Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein-Protein Interaction between Menin and Mixed Lineage Leukemia (MLL). Journal of Medicinal Chemistry 2016 59(3): 892-913. Doi: 10.1021/acs.jmedchem.5b01305
 
Costa MD, Ashraf NS, Fischer S, Yang, Schapka E, Joshi G, McQuade TJ, Dharia RM, Dulchavsky M, Ouyang M, Cook D, Sun D, Larsen MJ, Gestwicki JE, Todi SV, Ivanova MI, Paulson HL. Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3. Brain 2016 Sep 19. pii: aww228. [Epub ahead of print] PMID: 27645800 DOI:10.1093/brain/aww228

Guetschow ED, Kumar S, Lombard DB, Kennedy RT. Identification of sirtuin 5 inhibitors by ultrafast microchip electrophoresis using nanoliter volume samples. Analytical and Bioanalytical Chemistry 2016 408(3):721-731. Doi: 10.1007/s00216-015-9206-0

He S, Malik B, Borkin D, Miao H, Shukla S, Kempinska K, Purohit T, Wang J, Chen L, Parkin B, Malek SN, Danet-Desnoyers G, Muntean AG, Cierpicki T, Grembecka J. Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner. Leukemia 2016 Feb 30(2)508-13. doi: 10.1038/leu.2015.144. Epub 2015 Jun 18
 
Islam MK, Baudin M, Eriksson J, Öberg C, Habjan M, Weber F, Överby AK, Ahlm C, Evander M. High-Throughput Screening Using a Whole-Cell Virus ReplicationReporter Gene Assay to Identify Inhibitory Compounds against Rift Valley Fever Virus Infection. J Biomol Screen 2016 Jan 13. [Epub aheadof print] PubMed PMID: 26762502.

Metzger BPH, Duveau F, Yuan DC, Tryban S, Yang, B, Wittkopp PJ. Contrasting Frequencies and Effects of cis- and trans-Regulatory Mutations Affecting Gene Expression. Molecular Biology and Evolution 2016 33(5): 1131- 1146. Doi: 10.1093/molbev/msw011

Miller AL, Song JH, Sturza J, Lumeng, JC, Rosenblum K, Kaciroti N, Vazquez DM. Child cortisol moderates the association between family routines and emotion regulation in low-income children. Developmental Psychobiology 2016. doi: 10.1002/dev.21471
 
Mosli RH, Miller AL, Peterson KE, Kaciroti N, Rosenblum K, Baylin A, Lumeng JC. Birth order and sibship composition as predictors of overweight or obesity among low-income 4- to 8-year-old children. Pediatr Obes 2016 Feb 11(1):40-6. Epub 2015 Mar 2. PubMed PMID: 25735955; PubMed Central PMCID: PMC4558390.
 
Ouimet CM, Shao H, Rauch JN, Dawod M, Nordhues B, Dickey, CA, Gestwicki JE, Kennedy RT. Protein cross-linking capillary electrophoresis for protein-protein interaction analysis. Analytical Chemistry 2016 88(16): 8272-8278. Doi: 10.1021/acs.analchem.6b02126
 
Ozel AB, McGee B, Siemieniak D, Jacobi PM, Haberichter SL, Brody LC, Mills JL, Molloy AM, Ginsburg D, Li JZ, Desch KC. Genome-wide studies of von Willebrand factor propeptide identify loci contributing to variation in propeptide levels and von Willebrand factor clearance. Journal of Thrombosis and Haemostasis 2016 14 (9):1888-1898. Doi: 10.1111/jth.13401
 
Pang AH, Garzan A, Larsen MJ, McQuade TJ, Garneau-Tsodikova S, Tsodikov OV. Discovery of Allosteric and Selective Inhibitors of Inorganic Pyrophosphatase from Mycobacterium tuberculosis. ACS Chem Biol 2016 1(11) 3084–3092. DOI: 10.1021/acschembio.6b00510
 
Scharf, NT, Molodtsov V, Kontos A, Murakami KS, Garcia GA.  Novel Chemical Scaffolds for Inhibition of Rifamycin-Resistant RNA Ploymerase Discovered from High-Throughput Screening. SLAS Discovery 2016. DOI: 10.1177/1087057116679994
 
Sjogren B, Parra S, Atkins KB, Karaj B, Neubig RR. Digoxin-mediated up-regulation of RGS2 protein protects against cardiac injury. J Pharmacol Exp Ther 2016 May 357(2):311-9. doi: 10.1124/jpet.115.231571. Epub 2016 Mar 3.
 
Sun J, Groppi VE, Gui H, Chen L, Xie Q, Liu L, Omary MB. High-Throughput Screening for Drugs that Modulate Intermediate Filament Proteins. Methods in Enzymology 2016 568: 163-185. Doi: 10.1016/bs.mie.2015.09.029
 
Sun S, Buer BC, Marsh ENG, Kennedy, RT. A label-free Sirtuin 1 assay based on droplet-electrospray ionization mass spectrometry. Analytical Methods 2016 8(17): 3458- 3465. Doi: 10.1039/c6ay00698a
 
Willby MJ, Green KD, Gajadeera CS, Hou C, Tsodikov OV, Posey JE, Garneau-Tsodikova S. Potent Inhibitors of Acetyltransferase Eis Overcome Kanamycin Resistance in Mycobacterium tuberculosis. ACS Chemical Biology 2016 11(6): 1639- 1646. Doi: 10.1021/acschembio.6b00110
 
Zhao L, Marciano AT, Rivet CR, Imperiale MJ. Caveolin- and clathrin-independent entry of BKPyV into primary human proximal tubule epithelial cells. Virology 2016 492:66-72. Doi 10.1016/j.virol.2016.02.007.
 

2015

Anthouard R, DiRita VJ. Chemical biology applied to the study of bacterial pathogens. Infect Immun 2015 Feb 83(2):456-69. Epub 2014 Nov 17. Review. PubMed PMID: 25404026; PubMed Central PMCID: PMC4294262.
 
Barraza SJ, Delekta PC, Sindac JA, Dobry CJ, Xiang J, Keep RF, Miller DJ, Larsen SD. Discovery of anthranilamides as a novel class of inhibitors of neurotropic alphavirus replication. Bioorg Med Chem 2015 Apr 1 23(7):1569-87. Epub 2015 Feb 11. PubMed PMID: 25740634; PubMed Central PMCID: PMC4363283.
 
Bennett SM, Zhao L, Bosard C, Imperiale MJ. Role of a nuclear localization signal on the minor capsid proteins VP2 and VP3 in BKPyV nuclear entry. Virology 2015 Jan 1 474:110-6. Epub 2014 Nov 14. PubMed PMID: 25463609; PubMed Central PMCID: PMC4259852.
 
Blazer LL, Storaska AJ, Jutkiewicz EM, Turner EM, Calcagno M, Wade SM, Wang Q, Huang XP, Traynor JR, Husbands SM, Morari M, Neubig RR. Selectivity and Anti-Parkinson's Potential of Thiadiazolidinone RGS4 Inhibitors. ACS Chem Neurosci 2015 Jun 176(6)911-9. Epub 2015 Apr 20. PubMed PMID: 25844489.
 
Borkin D, He S, Miao H, Kempinska K, Pollock J, Chase J, Purohit T, Malik B, Zhao T, Wang J, Wen B, Zong H, Jones M, Danet-Desnoyers G, Guzman ML, Talpaz M, Bixby DL, Sun D, Hess JL, Muntean AG, Maillard I, Cierpicki T, Grembecka J. Pharmacologic inhibition of the Menin-MLL interaction blocks progression of MLL leukemia in vivo.Cancer Cell 2015 Apr 13 27(4)589-602. Epub 2015 Mar 26. Erratum in: Cancer Cell 2015 Apr 13 27(4):603-5. PubMed PMID: 25817203; PubMed Central PMCID: PMC4415852.
 
Brandvold KR, Santos SM, Breen ME, Lachacz EJ, Steffey ME, Soellner MB. Exquisitely Specific Bisubstrate Inhibitors of c-Src Kinase. ACS Chem Biol 2015 Jun 1910(6):1387-91. Epub 2015 Mar 31. PubMed PMID: 25793938.
 
Breen ME, Soellner MB. Small molecule substrate phosphorylation site inhibitors of protein kinases: approaches and challenges. ACS Chem Biol 2015 Jan 16 10(1):175-89. Epub 2014 Dec 23. PubMed PMID: 25494294; PubMed Central PMCID: PMC4301090.
 
Cierpicki T, Grembecka J. Targeting protein-protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies? Immunol Rev 2015 Jan 263(1):279-301. PubMed PMID: 25510283; PubMed Central PMCID: PMC4457300.
 
Cruz PG, Fribley AM, Miller JR, Larsen MJ, Schultz PJ, Jacob RT, Tamayo-Castillo G, Kaufman RJ, Sherman DH. Novel Lobophorins Inhibit Oral Cancer  Cell Growth and Induce Atf4- and Chop-Dependent Cell Death in Murine Fibroblasts. ACS Med Chem Lett 2015 Jul 66(8):877-81. eCollection 2015 Aug 13. PubMed PMID: 26288688; PubMed Central PMCID: PMC4538430.
 
Delekta PC, Raveh A, Larsen MJ, Schultz PJ, Tamayo-Castillo G, Sherman DH, Miller DJ.The combined use of alphavirus replicons and pseudoinfectious particles for the discovery of antivirals derived from natural products. J Biomol Screen 2015 Jun 20(5):673-80. Epub 2014 Dec 30. PubMed PMID: 25550354; PubMed Central PMCID: PMC4439314.
 
Dickson HM, Wilbur A, Reinke AA, Young MA, Vojtek AB. Targeted inhibition of the Shroom3-Rho kinase protein-protein interaction circumvents Nogo66 to promote axon outgrowth. BMC Neurosci. 2015 Jun 16;16:34. PubMed PMID: 26077244; PubMed Central PMCID: PMC4467669.
 
Elhassan ME, Miller AL, Vazquez DM, Lumeng JC. Associations of Prenatal and Perinatal Factors with Cortisol Diurnal Pattern and Reactivity to Stress at Preschool Age Among Children Living in Poverty. J Clin Res Pediatr Endocrinol 2015 Jun 7(2):114-20. PubMed PMID: 26316433; PubMed Central PMCID: PMC4563182.
 
Emanuele AA, Garcia GA. Mechanism of Action and Initial, In Vitro SAR of an Inhibitor of the Shigella flexneri Virulence Regulator VirF. PLoS One 2015 Sep 9 10(9). eCollection 2015. PubMed PMID: 26352269; PubMed Central PMCID: PMC4564171.
 
Gibbons GS, Owens SR, Fearon ER, Nikolovska-Coleska Z. Regulation of Wnt signaling target gene expression by the histone methyltransferase DOT1L. ACS Chem Biol 2015 Jan 16 10(1):109-14. Epub 2014 Nov 10. PubMed PMID: 25361163.
 
Gibbons GS, Showalter HD, Nikolovska-Coleska Z. Novel carboxaldehyde mediated synthetic pathway for 5'-amino adenosine analogues. Nucleosides Nucleotides Nucleic Acids 2015 34(5):348-60. doi: 10.1080/15257770.2014.1001074. PubMed PMID: 25874943.
 
Glukhova A, Hinkovska-Galcheva V, Kelly R, Abe A, Shayman JA, Tesmer JJ. Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase. Nat Commun 2015 Mar 2 6:6250. PubMed PMID: 25727495; PubMed Central PMCID: PMC4397983.
 
Green KD, Biswas T, Chang C, Wu R, Chen W, Janes BK, Chalupska D, Gornicki P, Hanna PC, Tsodikov OV, Joachimiak A, Garneau-Tsodikova S. Biochemical and structural analysis of an Eis family aminoglycoside acetyltransferase from bacillus anthracis. Biochemistry 2015 May 26 54(20):3197-206. Epub 2015 May 12. PubMed PMID: 25928210; PubMed Central PMCID: PMC4671295.
 
He S, Malik B, Borkin D, Miao H, Shukla S, Kempinska K, Purohit T, Wang J, Chen L, Parkin B, Malek SN, Danet-Desnoyers G, Muntean AG, Cierpicki T, Grembecka J. Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in  a fusion partner-independent manner. Leukemia 2016 Feb 30(2):508-13. Epub 2015 Jun 18. PubMed PMID: 26084867.
 
Homan KT, Waldschmidt HV, Glukhova A, Cannavo A, Song J, Cheung JY, Koch WJ, Larsen SD, Tesmer JJ. Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally Designed Inhibitor. J Biol Chem 2015 Aug 21 290(34):20649-59. Epub 2015 Jun 1. PubMed PMID: 26032411; PubMed Central PMCID: PMC4543626.
 
Hu B, Guo Y, Garbacz WG, Jiang M, Xu M, Huang H, Tsung A, Billiar TR,Ramakrishnan SK, Shah YM, Lam KS, Huang M, Xie W. Fatty acid binding protein-4(FABP4) is a hypoxia inducible gene that sensitizes mice to liverischemia/reperfusion injury. J Hepatol 2015 Oct 63(4):855-62. Epub 2015 Jun 10. PubMed PMID: 26070408.
 
Illendula A, Pulikkan JA, Zong H, Grembecka J, Xue L, Sen S, Zhou Y, Boulton A, Kuntimaddi A, Gao Y, Rajewski RA, Guzman ML, Castilla LH, Bushweller JH. Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice. Science 2015 Feb 13 347(6223):779-84. PubMed PMID: 25678665; PubMed Central PMCID: PMC4423805.
 
Johnson JG, Yuhas C, McQuade TJ, Larsen MJ, DiRita VJ. Narrow-Spectrum Inhibitors of Campylobacter jejuni Flagellar Expression and Growth. Antimicrob Agents Chemother 2015 Jul 59(7):3880-6. Epub 2015 Apr 13. PubMed PMID: 25870073.
 
Kretz CA, Dai M, Soylemez O, Yee A, Desch KC, Siemieniak D, Tomberg K, Kondrashov FA, Meng F, Ginsburg D. Massively parallel enzyme kinetics reveals the substrate recognition landscape of the metalloprotease ADAMTS13. Proc Natl Acad Sci USA 2015 Jul 28 112(30):9328-33. Epub 2015 Jul 13. PubMed PMID: 26170332; PubMed Central PMCID: PMC4522773.
 
Kwan R, Chen L, Looi K, Tao GZ, Weerasinghe SV, Snider NT, Conti MA, Adelstein RS, Xie Q, Omary MB. PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding. Hepatology 2015 Dec 62(6):1858-69. doi: 10.1002/hep.27965. Epub 2015 Aug 25. PubMed PMID: 26126491; PubMed Central PMCID: PMC4681638.
 
Lorenz DA, Song JM, Garner AL. High-throughput platform assay technology for the discovery of pre-microrna-selective small molecule probes. Bioconjug Chem 2015 Jan 21 26(1):19-23. Epub 2014 Dec 17. PubMed PMID: 25506628.
 
Lowell AN, Santoro N, Swaney SM, McQuade TJ, Schultz PJ, Larsen MJ, Sherman DH. Microscale Adaptation of In Vitro Transcription/Translation for High-Throughput Screening of Natural Product Extract Libraries. Chem Biol Drug Des 2015 Dec 86(6):1331-8. doi: 10.1111/cbdd.12614. Epub 2015 Jul 25. PubMed PMID: 26147927.      
 
Lund G, Dudkin S, Borkin D, Ni W, Grembecka J, Cierpicki T. Inhibition of CDC25B phosphatase through disruption of protein-protein interaction. ACS Chem Biol 2015 Feb 20 10(2):390-4. Epub 2014 Dec 1. PubMed PMID: 25423142; PubMed Central PMCID: PMC4340349.
 
Machiela MJ, Zhou W, Sampson JN, Dean MC, Jacobs KB, Black A, Brinton LA, Chang IS, Chen C, Chen C, Chen K, Cook LS, Crous Bou M, De Vivo I, Doherty J, Friedenreich CM, Gaudet MM, Haiman CA, Hankinson SE, Hartge P, Henderson BE, Hong YC, Hosgood HD 3rd, Hsiung CA, Hu W, Hunter DJ, Jessop L, Kim HN, Kim YH, Kim YT, Klein R, Kraft P, Lan Q, Lin D, Liu J, Le Marchand L, Liang X, Lissowska J, Lu L, Magliocco AM, Matsuo K, Olson SH, Orlow I, Park JY, Pooler L, Prescott J, Rastogi R, Risch HA, Schumacher F, Seow A, Setiawan VW, Shen H, Sheng X, Shin MH, Shu XO, VanDen Berg D, Wang JC, Wentzensen N, Wong MP, Wu C, Wu T, Wu YL, Xia L, Yang HP, Yang PC, Zheng W, Zhou B, Abnet CC, Albanes D, Aldrich MC, Amos C, Amundadottir LT, Berndt SI, Blot WJ, Bock CH, Bracci PM, Burdett L, Buring JE, Butler MA, Carreón T, Chatterjee N, Chung CC, Cook MB, Cullen M, Davis FG, Ding T, Duell EJ, Epstein CG, Fan JH, Figueroa JD, Fraumeni JF Jr, Freedman ND, Fuchs CS, Gao YT, Gapstur SM, Patiño-Garcia A, Garcia-Closas M, Gaziano JM, Giles GG, Gillanders EM, Giovannucci EL, Goldin L, Goldstein AM, Greene MH, Hallmans G, Harris CC, Henriksson R, Holly EA, Hoover RN, Hu N, Hutchinson A, Jenab M, Johansen C, Khaw  KT, Koh WP, Kolonel LN, Kooperberg C, Krogh V, Kurtz RC, LaCroix A, Landgren A, Landi MT, Li D, Liao LM, Malats N, McGlynn KA, McNeill LH, McWilliams RR, Melin BS, Mirabello L, Peplonska B, Peters U, Petersen GM, Prokunina-Olsson L, Purdue M, Qiao YL, Rabe KG, Rajaraman P, Real FX, Riboli E, Rodríguez-Santiago B, Rothman N, Ruder AM, Savage SA, Schwartz AG, Schwartz KL, Sesso HD, Severi G, Silverman DT, Spitz MR, Stevens VL, Stolzenberg-Solomon R, Stram D, Tang ZZ, Taylor PR, Teras LR, Tobias GS, Viswanathan K, Wacholder S, Wang Z, Weinstein SJ, Wheeler W, White E, Wiencke JK, Wolpin BM, Wu X, Wunder JS, Yu K, Zanetti KA, Zeleniuch-Jacquotte A, Ziegler RG, de Andrade M, Barnes KC, Beaty TH, Bierut LJ,  Desch KC, Doheny KF, Feenstra B, Ginsburg D, Heit JA, Kang JH, Laurie CA, Li JZ,  Lowe WL, Marazita ML, Melbye M, Mirel DB, Murray JC, Nelson SC, Pasquale LR, Rice K, Wiggs JL, Wise A, Tucker M, Pérez-Jurado LA, Laurie CC, Caporaso NE, Yeager M, Chanock SJ. Characterization of large structural genetic mosaicism in human autosomes. Am J Hum Genet 2015 Mar 5 96(3):487-97. PubMed PMID: 25748358; PubMed Central PMCID: PMC4375431.
 
Malik R, Khan AP, Asangani IA, Cieślik M, Prensner JR, Wang X, Iyer MK, Jiang X, Borkin D, Escara-Wilke J, Stender R, Wu YM, Niknafs YS, Jing X, Qiao Y, Palanisamy N, Kunju LP, Krishnamurthy PM, Yocum AK, Mellacheruvu D, Nesvizhskii AI, Cao X, Dhanasekaran SM, Feng FY, Grembecka J, Cierpicki T, Chinnaiyan AM. Targeting the MLL complex in castration-resistant prostate cancer. Nat Med 2015 Apr 21(4):344-52. Epub 2015 Mar 30. PubMed PMID: 25822367; PubMed Central PMCID: PMC4390530.
 
Makley LN, McMenimen KA, DeVree BT, Goldman JW, McGlasson BN, Rajagopal P, Dunyak BM, McQuade TJ, Thompson AD, Sunahara R, Klevit RE, Andley UP, Gestwicki JE. Pharmacological chaperone for α-crystallin partially restores transparency in cataract models. Science 2015 Nov 6 350(6261):674-7. PMID: 26542570; PubMed Central PMCID: PMC4725592.
 
Miller AL, Lee HJ, Lumeng JC. Obesity-associated biomarkers and executive function in children. Pediatr Res 2015 Jan 77(1-2):143-7. Epub 2014 Oct 13. Review. PubMed PMID: 25310758; PubMed Central PMCID: PMC4416088.
 
Miller AL, Sturza J, Rosenblum K, Vazquez DM, Kaciroti N, Lumeng JC. Salivary alpha amylase diurnal pattern and stress response are associated with body mass index in low-income preschool-aged children. Psychoneuroendocrinology 2015 Mar; 3:40-8. Epub 2014 Dec 22. PubMed PMID: 25588701; PubMed Central PMCID: PMC4336565.
 
Pesch MH, Wentz EE, Rosenblum KL, Appugliese DP, Miller AL, Lumeng JC. "You've got to settle down!": Mothers' perceptions of physical activity in their youngchildren. BMC Pediatr 2015 Oct 815:149. PubMed PMID: 26450612; PubMed Central PMCID: PMC4598974.
 
Pollock J, Borkin D, Lund G, Purohit T, Dyguda-Kazimierowicz E, Grembecka J, Cierpicki T. Rational Design of Orthogonal Multipolar Interactions with Fluorine in Protein-Ligand Complexes. J Med Chem 2015 Sep 24 58(18):7465-74. Epub 2015 Sep 6. PubMed PMID: 26288158; PubMed Central PMCID: PMC4584387.
 
Qian J, Kong X, Deng N, Tan P, Chen H, Wang J, Li Z, Hu Y, Zou W, Xu J, Fang JY. OCT1 is a determinant of synbindin-related ERK signalling with independent prognostic significance in gastric cancer. Gut 2015 Jan 64(1):37-48. Epub 2014 Apr 9. PubMed PMID: 24717932; PubMed Central PMCID: PMC4283676
 
Ranghini EJ, Dressler GR. Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms. Dev Biol 2015 Mar 15 399(2):296-305. Epub 2015 Jan 21. PubMed PMID: 25617721; PubMed Central PMCID: PMC4352407.
 
Ramani B, Harris GM, Huang R, Seki T, Murphy GG, Costa Mdo C, Fischer S, Saunders TL, Xia G, McEachin RC, Paulson HL. A knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript. Hum Mol Genet 2015 Mar 1 24(5):1211-24. Epub 2014 Oct 15. PubMed PMID: 25320121; PubMed Central PMCID: PMC4321438
 
Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause  DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans  RM, Saltiel AR. A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis. Nat Commun 2015 Jan 12 6:6047. PubMed PMID: 25581158; PubMed Central PMCID: PMC4324568.
 
Scanlon CS, Banerjee R, Inglehart RC, Liu M, Russo N, Hariharan A, van Tubergen EA, Corson SL, Asangani IA, Mistretta CM, Chinnaiyan AM, D'Silva NJ. Galanin modulates the neural niche to favour perineural invasion in head and neck cancer. Nat Commun 2015 Apr 28 6:6885. PubMed PMID: 25917569; PubMed Central PMCID: PMC4476386.
 
Schofield MM, Jain S, Porat D, Dick GJ, Sherman DH. Identification and analysis of the bacterial endosymbiont specialized for production of thechemotherapeutic natural product ET-743. Environ Microbiol 2015 Oct 17(10):3964-75. Epub 2015 Jul 21. PubMed PMID: 26013440; PubMed Central PMCID: PMC4618771.
 
Senter T, Gogliotti RD, Han C, Locuson CW, Morrison R, Daniels JS, Cierpicki T, Grembecka J, Lindsley CW, Stauffer SR. Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utility. Bioorg Med Chem Lett 2015 Jul 1 25(13):2720-5. Epub 2015 Apr 25. PubMed PMID: 25987377.
 
Sisson TH, Ajayi IO, Subbotina N, Dodi AE, Rodansky ES, Chibucos LN, Kim KK, Keshamouni VG, White ES, Zhou Y, Higgins PD, Larsen SD, Neubig RR, Horowitz JC. Inhibition of myocardin-related transcription factor/serum response factor signaling decreases lung fibrosis and promotes mesenchymal cell apoptosis. Am J Pathol 2015 Apr 185(4):969-86. Epub 2015 Feb 11. PubMed PMID: 25681733; PubMed Central PMCID: PMC4380846.
 
Sjögren B, Swaney S, Neubig RR. FBXO44-Mediated Degradation of RGS2 Protein Uniquely Depends on a Cullin 4B/DDB1 Complex. PLoS One 2015 May 13 10(5):e0123581. eCollection 2015. PubMed PMID: 25970626; PubMed Central PMCID: PMC4430315.
 
Sterne GR, Kim JH, Ye B. Dysregulated Dscam levels act through Abelson tyrosine kinase to enlarge presynaptic arbors. Elife 2015 May 19: 4. PubMed PMID: 25988807; PubMed Central PMCID: PMC4434255.
 
Wei D, Zhang Q, Schreiber JS, Parsels LA, Abulwerdi FA, Kausar T, Lawrence TS, Sun Y, Nikolovska-Coleska Z, Morgan MA. Targeting mcl-1 for radiosensitization of pancreatic cancers. Transl Oncol 2015 Feb 8(1):47-54. PubMed PMID: 25749177; PubMed Central PMCID: PMC4350640.
 
Wong PT, Leroueil PR, Smith DM, Ciotti S, Bielinska AU, Janczak KW, Mullen CH, Groom JV 2nd, Taylor EM, Passmore C, Makidon PE, O'Konek JJ, Myc A, Hamouda T, Baker JR Jr. Formulation, high throughput in vitro screening and in vivo functional characterization of nanoemulsion-based intranasal vaccine adjuvants. PLoS One. 2015 May 11 10(5):e0126120. eCollection 2015. PubMed PMID: 25962136; PubMed Central PMCID: PMC4427474.
 
Xi Y, Garshott DM, Brownell AL, Yoo GH, Lin HS, Freeburg TL, Yoo NG, Kaufman RJ, Callaghan MU, Fribley AM. Cantharidins induce ER stress and a terminal unfolded protein response in OSCC. J Dent Res 2015 Feb 94(2):320-9. Epub 2014 Nov 25. PubMed PMID: 25425581.
 

2014

 
Abulwerdi FA, Liao C, Mady AS, Gavin J, Shen C, Cierpicki T, Stuckey JA, Showalter HD, Nikolovska-Coleska Z. 3-Substituted-N-(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation. J Med Chem 2014 (57) 4111.
 
Cao F, Townsend EC, Karatas H, Xu J, Li L, Lee S, Liu L, Chen Y, Ouillette P, Zhu J, Hess JL, Atadja P, Lei M, Qin ZS, Malek S, Wang S, Dou Y. Targeting MLL1 H3K4 methyltransferase activity in mixed-lineage leukemia. Mol Cell 2014 Jan 23 53(2):247-61. doi: 10.1016/j.molcel.2013.12.001. Epub 2014 Jan 2. PubMed PMID: 24389101; PubMed Central PMCID: PMC3965208.
 
Caruso R, Warner N, Inohara N, Núñez G. NOD1 and NOD2: signaling, host defense, and inflammatory disease. Immunity 2014 Dec 18 41(6):898-908. doi: 10.1016/j.immuni.2014.12.010. Epub 2014 Dec 6. Review. PubMed PMID: 25526305; PubMed Central PMCID: PMC4272446.
 
Cierpicki T, Grembecka J. Challenges and opportunities in targeting the menin-MLL interaction. Future Med Chem 2014 Mar 6(4):447-62. doi: 10.4155/fmc.13.214. Review. PubMed PMID: 24635524; PubMed Central PMCID: PMC4138051.
 
Delekta PC, Raveh A, Larsen MJ, Schultz PJ, Tamayo-Castillo G, Sherman DH, Miller DJ. The Combined Use of Alphavirus Replicons and Pseudoinfectious Particles for the Discovery of Antivirals Derived from Natural Products. J Biomol Screen. 2014 Dec 30. pii: 1087057114564868. [Epub ahead of print] PubMed PMID: 25550354. Pubmed link.
 
Duveau F, Metzger BP, Gruber JD, Mack K, Sood N, Brooks TE, Wittkopp PJ. Mapping small effect mutations in Saccharomyces cerevisiae: impacts of experimental design and mutational properties. G3 (Bethesda). 2014 Apr 29;4(7):1205-16.
 
Haak AJ, Tsou P-S, Amin MA, Ruth JH, Campbell O, Fox DA, Khanna D, Larsen SD, Neubig RR. Targeting the myofibroblast genetic switch: inhibitors of MRTF/SRF-regulated gene transcription prevent fibrosis in a murine model of skin injury. American Society for Pharmacology and Experimental Therapeutics. 2014 April 4.
 
He S, Senter TJ, Pollock J, Han C, Upadhyay SK, Purohit T, Gogliotti RD, Lindsley CW, Cierpicki T, Stauffer SR, Grembecka J. High-affinity small-molecule inhibitors of the menin-mixed lineage leukemia (MLL) interaction closely mimic a natural protein-protein interaction. J Med Chem. 2014 Feb 27;57(4):1543-56. doi: 10.1021/jm401868d. Epub 2014 Feb 6. PubMed PMID: 24472025; PubMed Central PMCID: PMC3983337.
 
Homan KT, Wu E, Cannavo A, Koch WJ, Tesmer JJ. Identification and characterization of amlexanox as a G protein-coupled receptor kinase 5 inhibitor. Molecules. 2014 Oct 22;19(10):16937-49. doi: 10.3390/molecules191016937. PubMed PMID: 25340299.
 
Larsen MJ, Larsen SD, Fribley A, Grembecka J, Homan K, Mapp A, Haak A, Nikolovska-Coleska Z,. Stuckey JA, Sun D, Sherman DH. The Role of HTS in Drug Discovery at the University of Michigan, Combinatorial Chemistry & High Throughput Screening, 2014, 17, 210-230.
 
Law SM, Gagnon JK, Mapp AK, Brooks CL 3rd. Prepaying the entropic cost for allosteric regulation in KIX. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12067-72. doi: 10.1073/pnas.1405831111. Epub 2014 Jul 7. PubMed PMID: 25002472; PubMed Central PMCID: PMC4143015.
 
Lodge JM, Rettenmaier TJ, Wells JA, Pomerantz WC, Mapp AK. FP Tethering: a screening technique to rapidly identify compounds that disrupt protein-protein interactions. Medchemcomm. 2014 Mar 1;5:370-375. PubMed PMID: 24795804; PubMed Central PMCID: PMC4005387.
 
Lund G, Cierpicki T. Solution NMR studies reveal no global flexibility in the catalytic domain of CDC25B. Proteins 2014 Apr 17.
 
Martin BN, Wang C, Willette-Brown J, Herjan T, Gulen MF, Zhou H, Bulek K, Franchi L, Sato T, Alnemri ES, Narla G, Zhong XP, Thomas J, Klinman D, Fitzgerald KA, Karin M, Nuñez G, Dubyak G, Hu Y, Li X. IKKα negatively regulates ASC-dependent inflammasome activation. Nat Commun. 2014 Sep 30;5:4977. doi: 10.1038/ncomms5977. PubMed PMID: 25266676; PubMed Central PMCID: PMC4298287.
 
Murai MJ, Pollock J, He S, Miao H, Purohit T, Yokom A, Hess JL, Muntean AG, Grembecka J, Cierpicki T. The same site on the integrase-binding domain of lens epithelium-derived growth factor is a therapeutic target for MLL leukemia and HIV. Blood. 2014 Dec 11;124(25):3730-7. doi: 10.1182/blood-2014-01-550079. Epub 2014 Oct 10. PubMed PMID: 25305204; PubMed Central PMCID: PMC4263982. Pubmed link.
 
Rauch JN, Gestwicki JE. Binding of human nucleotide exchange factors to heat shock protein 70 (Hsp70) generates functionally distinct complexes in vitro. J Biol Chem. 2014 Jan 17;289(3):1402-14. doi: 0.1074/jbc.M113.521997. Epub 2013 Dec 5. PubMed PMID: 24318877; PubMed Central PMCID: PMC3894324.
 
Raveh A, Schultz PJ, Aschermann L, Carpenter C, Tamayo-Castillo G, Cao S, Clardy J, Neubig RR, Sherman DH, Sjögren B. Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts. Mol Pharmacol. 2014 Oct;86(4):406-16. doi:10.1124/mol.114.092403. Epub 2014 Aug 1. PubMed PMID: 25086086.
 
Sun S, Kennedy RT. Droplet electrospray ionization mass spectrometry for high  throughput screening for enzyme inhibitors. Anal Chem. 2014 Sep 16;86(18):9309-14.Epub 2014 Aug 26. PubMed PMID: 25137241; PubMed Central PMCID: PMC4165461.
 
Suzuki S, Mimuro H, Kim M, Ogawa M, Ashida H, Toyotome T, Franchi L, Suzuki M, Sanada T, Suzuki T, Tsutsui H, Núñez G, Sasakawa C. Shigella IpaH7.8 E3 ubiquitin ligase targets glomulin and activates inflammasomes to demolish macrophages. Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4254-63. doi: 10.1073/pnas.1324021111. Epub 2014 Sep 22. PubMed PMID: 25246571; PubMed Central PMCID: PMC4210038.
 
Tripathi A, Schofield MM, Chlipala,GE, Schultz PJ, Yim I, Newmister SA, Nusca TD, Scaglione JB, Hanna PC, Tamayo-Castillo G, Sherman DH. Baulamycins A and B, broad-spectrum antibiotics identified as inhibitors of siderophore biosynthesis in Staphylococcus aureus and Bacillus anthracis. J Amer Chem Soc 2014, 136(4):1579-1586.
 
Walter GM, Raveh A, Mok SA, McQuade TJ, Arevang CJ, Schultz PJ, Smith MC, Asare S, Cruz PG, Wisen S, Matainaho T, Sherman DH, Gestwicki JE. High-throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity. Chem Biol Drug Des. 2014 Apr;83(4):440-9. doi:10.1111/cbdd.12259. PubMed PMID: 24636344.
 
Wang N, Lodge JM, Fierke CA, Mapp AK. Dissecting allosteric effects of activator-coactivator complexes using a covalent small molecule ligand. Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12061-6. doi: 10.1073/pnas.1406033111. Epub 2014 Jul 21. PubMed PMID: 25049401; PubMed Central PMCID: PMC4143068.
 
Warner N, Burberry A, Pliakas M, McDonald C, Núñez G. A genome-wide siRNA screen reveals NF-κB independent regulators of NOD2-induced IL-8 secretion. J Biol Chem. 2014 Aug 28.
 
Warner N, Burberry A, Pliakas M, McDonald C, Núñez G. A genome-wide small interfering RNA (siRNA) screen reveals nuclear factor-κB (NF-κB)-independent regulators of NOD2-induced interleukin-8 (IL-8) secretion. J Biol Chem. 2014 Oct 10;289(41):28213-24. doi: 10.1074/jbc.M114.574756. Epub 2014 Aug 28. PubMed PMID: 25170077; PubMed Central PMCID: PMC4192477.
 
Wolfson NA, Pitcairn CA, Sullivan ED, Joseph CG, Fierke CA. An enzyme-coupled assay measuring acetate production for profiling histone deacetylase specificity. Anal Biochem. 2014 Jul 1;456:61-9. doi: 10.1016/j.ab.2014.03.012. Epub 2014 Mar 25. PubMed PMID: 24674948; PubMed Central PMCID: PMC4470474.
 
Xin Liu, Yu Chen and Carol A. Fierke. A real-time fluorescence polarization activity assay to screen for inhibitors of bacterial ribonuclease P. Nucleic Acids Res. 2014 Nov 10;42(20):e159. doi: 10.1093/nar/gku850. Epub 2014 Sep 23.
 
Yep A, McQuade T, Kirchhoff P, Larsen M, Mobley HLT. (2014)Inhibitors of TonB function identified by a high-throughput screen for inhibitors of iron 1 acquisition in uropathogenic E. coli CFT073, mBio. 2014 Mar-Apr; 5(2): e01089-13.
 
Zhang A, Dong B, Doucet AJ, Moldovan JB, Moran JV, Silverman RH. RNase L restricts the mobility of engineered retrotransposons in cultured human cells. Nucleic Acids Res. 2014 Apr;42(6):3803-20. doi: 10.1093/nar/gkt1308. Epub 2013 Dec 25. PubMed PMID: 24371271; PubMed Central PMCID: PMC3973342. 
 

2013

Anthouard R, DiRita VJ. Small-Molecule Inhibitors of toxT Expression in Vibrio cholerae. 2013
 
Bell JL, Haak AJ, Wade SM, Sun Y, Neubig RR, Larsen SD. Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway.  Beilstein J Org Chem 2013 (9) 966-73.
 
Bell J.L.; Haak, A.J.; Wade, S.M., Kirchhoff, P.D.; Neubig, R.R.; Larsen S.D. “Optimization of Novel Nipecotic Bis(amide) Inhibitors of the Rho/MKL1/SRF Transcriptional Pathway as Potential Anti-metastasis Agents”, Bioorg. Med. Chem. Lett. 2013, 23, 3826-32
 
Biswas T, Green KD, Garneau-Tsodikova S, Tsodikov OV. Discovery of inhibitors of Bacillus anthracis primase DnaG. Biochemistry. 2013 Oct 1;52(39):6905-10. Epub 2013 Sep 19. PubMed PMID: 24004110.
 
Gaji RY, Huynh M-H, Carruthers. A novel high throughput invasion screen identifies host actin regulators required for efficient cell entry by Toxoplasma gondii. PLoS ONE 2013 8(5): e64693. doi:10.1371/journal.pone.0064693.
 
Nance MR, Kreutz B, Tesmer VM, Sterne-Marr R, Kozasa T, Tesmer JJ. Structural and Functional Analysis of the Regulator of G Protein Signaling 2-Gαq Complex. Structure 2013 March 5 21 (3) 448.
 
Rauch JN, Ni J, Buchholz TJ, Gestwicki JE, Kennedy RT. Development of a Capillary Electrophoresis Platform for Identifying Inhibitors of Protein–Protein Interactions Anal Chem 2013 85 (20) 9824–9831.
 
Raveh A, Delekta PC, Dobry CJ, Schultz, P J, Blakely PK, Tai AW., Matainaho T, Irani DN, Sherman, DH, Miller DJ. Discovery of potent broad spectrum antivirals derived from marine actinobacteria.  PLoS One. 5 Dec 2013, 8(12):e82318.
 
Reilly, SM et al. An inhibitor of the protein kinases TBK1 and IKK-e improves obesity-related metabolic dysfunctions in mice. Nature Medicine (2013) 19, 313-321.  doi:10.1038/nm.3082. PubMed link.
 
Warner, N et al. A Genome-Wide siRNA Screen Reveals Positive and Negative Regulators of the NOD2 and NF-kB Signaling Pathways. Sci Signal (2013) Jan 15;6(258):rs3. doi: 10.1126/scisignal.2003305. 
 
Storaska AJ, Mei JP, Wu M, Li M, Wade SM, Blazer LL, Sjögren B, Hopkins, CR, Lindsley CW, Lin Z,. Babcock JJ, McManus OB, Neubig RR. Reversible inhibitors of regulators of G-protein signaling identified in a high-throughput cell-based calcium signaling assay. Cellular Signalling 2013 December 25(12) 2848-2855.
 
Storaska AJ, Neubig RR. NMR Methods for Detection of Small Molecule Binding to RGS4 in Methods in Enzymology. 2013 522:133-152.
 
Vashisth H, Storaska AJ, Neubig RR, Brooks CL 3rd. Conformational dynamics of a regulator of G-protein signaling protein reveals a mechanism of allosteric inhibition by a small molecule. ACS Chem Biol 2013 Dec 20;8(12):2778-84. doi: 10.1021/cb400568g. Epub 2013 Oct 24. PubMed PMID: 24093330; PubMed Central PMCID: PMC3876963.
 
Yestrepsky, B.D.; Xu, Y.; Sorenson, R.J.; Wilson, M.W.; Ryu, J.; Rajaswaran, W.; Breen, M.E.; Tsume, Y.; Zhang, W.; Li, X.; Sun, D.; Sun, H.; Larsen S.D. “Novel Inhibitors of Bacterial Virulence: Development of 5,6-Dihydrobenzo[h]quinazoline-4(3H)-ones for the Inhibition of Group A Streptococcal Streptokinase Expression”, Bioorg. Med. Chem. 2013, 21, 1880-97
 

2012

Green KD, et al. (2012) Identification and characterization of inhibitors of the aminoglycoside resistance acetyltransferase Eis from Mycobacterium tuberculosis. ChemMedChem Jan 2;7(1):73-77. doi:  10.1002/cmdc.201100332.  Epub 2011 Sep 5  
 
Gruber JD, Vogel K, Kalay G, Wittkopp PJ; Contrasting properties of gene-specific regulatory, coding, and copy number mutations in Saccharomyces cerevisiae: Frequency, Effects and Dominance. (2012) PLoS Genet 8(2): e1002497. doi:10.1371/journal.pgen.1002497
 
Jacob RT, et al. MScreen: an integrated compound management and high-throughput screening data storage and analysis system. J Biomol Screen, (2012) Sep;17(8):1080-1087. Epub 2012 June 15  
 
Larsen, MJ et al. Functional Expression and Characterization of the C. elegans G-protein-coupled FLP-2 Receptor (T19F4.1) in Mammalian Cells and Yeast. Intl J Parasit: Drugs and Drug Resistance 2012 3, 1-7.
 
Ma, Y.; Xu, Y.; Yestrepsky, B.D.; Sorenson, R.J.; Chen, M.; Larsen S.D.; Sun, H. “Novel inhibitors of Staphylococcus aureus virulence gene expression and biofilm formation”, PLoS ONE2012, 7, e47225.
 
Sindac, J.S.; Yestrepsky, B.D.; Barraza, S.J.; Bolduc, K.L.; Blakely, P.K.; Keep, R.F.; Irani, D.N.; Miller, D.J.; Larsen S.D. “Novel Inhibitors of Neurotropic Alphavirus Replication That Improve Host Survival in a Mouse Model of Acute Viral Encephalitis”, J Med Chem  2012, 55, 3535-45.
 
Majmudar CY, et al. Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300. Angew Chem Int Ed Engl, (2012) Nov 5;51(45):11258-62. doi: 10.1002/anie.201206815. Epub 2012 Oct 8. 
 
Seguin SP, et al. A screen for modulators of large T antigen's ATPase activity uncovers novel inhibitors of Simian Virus 40 and BK virus replication. Antiviral Res, 2012 Aug 7;96(1):70-81. [Epub ahead of print]
 
Sjogren B, et al. Cardiotonic steroids stabilize RGS2 protein levels. Molecular Pharmacology (2012) 82;3;500-509, doi: 10.1124/mol.112.079293
 
Sun H, et al. (2012) Inhibitor of streptokinase gene expression improves survival after group A streptococcus infection in mice. PNAS Feb 28;109(9);3469-74  Epub 2012 Feb 13  PubMed link
Grembecka J, et al. (2012) Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia. Nat Chem Biol. Jan 29;8(3):277-84. doi: 10.1038/nchembio. 773. 
 
Tesmer VM, Lennarz S, Mayer G, Tesmer JJ. Molecular Mechanism for Inhibition of G Protein-Coupled Receptor Kinase 2 by a Selective RNA Aptamer. Structure. 2012 August 8 20(8)1300-1309.
 
Thal DM, et al. Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. ACS Chem Biol (2012) Nov 16;7(11): 1830-9. doi: 10.1021/cb3003013. Epub 2012 Aug 21.
 
Wang Y, et al. (2012) Small molecule screening identifies regulators of the transcription factor. DeltaFosB. ACS Chem Neurosci, (2012) 3;546-56.