Past events

Archived UM Structure Seminars

Friday, December 19, 2014: Undergraduates Improve upon Published Crystal Structure in Class Assignment, Scott Horowitz, Ph.D., James Bardwell Lab

Friday, December 12, 2014: Structure and function of SMYD proteins, by Zhe Yang, Ph.D., Assistant Professor, Wayne State University (external)

Friday, December 5, 2014: Architectural Insights into the AAA+ Proteins Rvb1 and Rvb2, by Caroline Ewens, Daniel Southworth Lab

Friday, Novemeber 7, 2014: Crystallographic Comparison of Thiolate-Rich Sites in Designed Proteins to Control Metal Geometries, by Leela Ruckthong, Jeanne Stuckey Lab

Friday, November 14, 2014: Structural Insight Into Basis for G-alpha Selectivity of RGS Proteins, by Veronica Taylor, John Tesmer Lab

Friday, October 31, 2014: Capturing the pH Response of the Acid-Shock Chaperone HdeA, by Logan Ahlstrom, Charles Brooks Lab

Friday, October 24, 2014: Nitric-oxide Synthase Holoenzymes Reveal Large Conformational Changes to Facilitate FMN Domain Docking, by Adam Yokom, Daniel Southworth Lab

Friday, October 17, 2014: "How gut bacteria eat your veggies: the molecular details of carbohydrate uptake by human gut Bacteroidetes," by Nicole Koropatkin, Ph.D.

Friday, August 15, 2014: "A novel approach to inhibit the Antigen 85 Complex from Mycobacterium tuberculosis," Lorenza Favrot, Ph.D., University of Toledo, (external)

Friday, May 23, 2014: "Biochemical and structural studies at the interface between the RMI core complex and FANCM," Kelly Manthei, Ph.D., James Keck Lab, University of Wisconsin-Madison (external)

Friday, May 9, 2014: "Structural studies on the regulation of P-Rex1, an enhancer of metastatic potential," by Jennifer Cash, John Tesmer Lab, LSI

Friday, April 25, 2014: "Structural Biology of G-Protein Coupled Receptors," by H. Eric Xu, Ph.D., Head of Laboratory of Structural Sciences, Van Andel Research Institute (External)

Friday, April 18, 2014: "Regulation of Phospholipase Cβ through Progressive Destabilization," by Angeline Lyon, John Tesmer Lab, LSI

Friday, April 11, 2014: "The Rational Design of Inhibitors that Bind to the Inactive Form of the Kinase," by Frank Kwarcinski, Jeanne Stuckey and Matthew Soellner Labs, LSI and Medicinal Chemistry

Friday, April 4, 2014: "Structure and function of cytochrome P450 2B4 F429H with a hydrogen bond between the axial cysteine and histidine residues," by Yuting Yang, Lucy Waskell Lab, Department of Anesthesiology

Friday, March 28, 2014: "High-order oligomeric assemblies of the RIG-I like helicases for viral dsRNA detection and signal transduction," by Alys Peisley, Ph.D., Sun Hur Lab, Harvard Medical School (External)

Friday, March 21, 2014: "Mechanism of the Chaperone Spy: A Biochemical and Structural Investigation," by Scott Horowitz, Ph.D., and Philipp Koldewey, James Bardwell Lab, Depart. of Molecular, Cellular, and Developmental Biology

Friday, March 14, 2014: "Carbohydrate recognition by human gut bacteria," by Nicole Koropatkin, Research Assistant Professor, Department of Microbiology and Immunology

Friday, March 7, 2014: "How old enzymes learn new tricks: Evolutionary Exploitation of Promiscuous NSAR/OSBS Enzymes," by Margaret E. Glasner, Ph.D., Department of Biochemistry and Biophysics, Texas A&M University (External)

Friday, February 28, 2014: "Selective inhibitors of the G protein-coupled receptor kinases," by Kristoff Homan, John Tesmer Lab, LSI

Friday, January 31, 2014: "Finding Low Affinity Ligands with X-ray Crystallography: Electron Density Peaks among the Green Mountains," by Nicolas Villanueva, Roger Sunahara Lab, Department of Pharmacology Jeanne Stuckey, LSI/CSB

Friday, January 24, 2014: "ESCRT-III protein IST1 interacts with Spartin, VPS4 and LIP5 using different molecular mechanisms," by Emily Guo, Zhaohui Xu Lab, LSI

Friday, January 17, 2014: "Structural Investigation of the Mechanism and Regulation of PLPS," by Amber Smith, Janet Smith Lab, LSI

Friday, January 10, 2014: "Structural Studies of Amyloid Peptides Using Microfocus X-ray Diffraction," by Magdalena Ivanova, Research Assistant Professor, Neurology Department

Friday, December 6, 2013: "Conservation and Functional Importance of Carbon-Oxygen Hydrogen Bonding in AdoMet-Dependent Methyltransferases," by Ray Trievel, Associate Professor, Department of Biological Chemistry

Friday, November 22, 2013:  “Development of deubiquitinase inhibitors as a new class of anti-cancer therapeutics,” by Matt Young, Assistant Professor, Department of Pharmacology

Friday, November 15, 2013: "Vfa1: a novel regulator in the ESCRT pathway," by Cody Vild, Zhaohui Xu Lab, LSI

Friday, November 8, 2013: "Structural and functional analysis of Lysosomal Phospholipase A2, a close homolog of Lecithin Cholesterol Acyl Transferase," by Alisa Glukhova, John Tesmer Lab, LSI

Friday, October 25, 2013:  "De novo computational protein design," David Shultis, Yang Zhang Lab, Dept. of Computational Medicine & Bioinformatics

Friday, October 18, 2013:  "Discovery and characterization of a small molecule probe targeting the protein-protein interactions of CDK2/CycA," by George Lund, Cierpicki Lab, Department of Pathology

Friday, September 27, 2013: "How telomerase is recruited to chromosomal DNA ends coated with telomeric proteins," by Jayakrishnan (JK) Nandakumar, Asst. Prof. of Molecular, Cellular and Developmental Biology, LSA

Friday, September 13, 2013: "Extending MixMD to Allosteric Systems" by Phani Ghanakota, Heather Carlson Lab

Friday, September 6, 2013: "Structural investigations of vitamin B-12 biosynthetic enzymes" by Sean Newmister, David Sherman Lab

Archived Seminars of Interest

Tuesday, December 2, 2014, 12 - 1 P.M.
Justin Kollman, McGill
Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Daniel Southworth

Friday, December 5, 2014, 4 - 5:00 P.M.
Jim Hurley, UC Berkeley, Molecular & Cell Biology
Biophysics Seminar, 1300 Chemistry
Host: Ray Trievel, Ph.D.

Tuesday, December 9, 2014, 12 - 1 P.M.
Juli Feigon, PhD, University of California Los Angeles
Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Erik Zuiderweg

Tuesday, December 16, 2014, 12 - 1 P.M.
Jochen Zimmer, University of Virginia

Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Yiorgio Skiniotis

Tuesday, October 28th, 2014, 12 - 1 P.M.
Karen Anderson, Yale University School of Medicine
Biological Chemistry, Seminar, North Lecture Hall, Med Sci II
Host: Ruma Banerjee

Monday, October 27th, 2014, 1:00
Public Oral Examination for the Degree of Doctor of Philosophy
"Structural Investigation of the Mechanism and Regulation of the PLPS" by Amber M. Smith
6311 Medical Science I

Friday, May 9, 2014, 4:00
Steve Scheiner, Utah State University
"Hiding in plain sight: the CH-O hydrogen bond"
Biophysics Seminar, 1300 Chemistry
Host: Ray Trievel, Ph.D.

Friday, May 2, 2014 10:00
Tom D. Hurley, Ph.D., Indiana University (External)
"Activation and Inhibition of Aldehyde Dehydrogenases: A random walk through a small molecule wilderness"
Center for the Discovery of New Medicines
Palmer Commons, Forum Hall
Hosts: Shaomeng Wang, Ph.D. & Ronald Buckanovich, M.D., Ph.D.

Tuesday, April 29, 2014, 12:00
Celia Goulding, Ph.D.
University of California at Irvine (External)
"Structural insights into mechanisms of bacterial survival”
North Lecture Hall, MS II
Host: Stephen Ragsdale

Friday, April 4, 2014, 12:00
Jennifer A. Johnston, Ph.D., Founder and CSO, An2H Discovery, San Francisco, CA
"Structural mechanisms and small molecule compounds regulating Parkin enzyme activation"
Pharmacology Seminar, 2813 / 2817 Med Sci II
Host: Matt Young, Ph.D.

Tuesday, April 1, 2014, 12:00
Yifan Cheng, UCSF
"Membrane protein structure determination by single particle cryoEM"
Biological Chemistry Seminar, North Lecture Hall, Med Sci II
Host: Yiorgo Skiniotis EM

Friday, March 28, 2014, 4:00
Dr. Philipp Selenko, Group Leader In-cell NMR Spectroscopy, & Leibniz Institute of Molecular Pharmacology, Berlin
“Looking at Proteins Inside Live Cells with Atomic Resolution: Science Fiction or Science Reality?”
Biophysics Seminar, 1300 Chemistry

Tuesday, March 25, 2014, 12:00
“Seeing the Invisible by Solution NMR”
Lewis E. Kay, University of Toronto
Biological Chemistry Seminar, North Lecture Hall, Med Sci II

Tuesday, March 11, 2014, 12:00
“A Structural Biology Approach to the Treatment of Alzheimer's Disease”
Greg Petsko, Brandeis University
Biological Chemistry Seminar, North Lecture Hall, Med Sci II
Martha Ludwig Lectureship

Tuesday, March 4, 2014, 12:00
“New insights to RNA processing and decay by the eukaryotic RNA exosome”
Chris Lima, Ph.D., Sloan-Kettering Institute
Biological Chemistry Seminar, North Lecture Hall, Med Sci II

Friday, December 13, 2013, 4:00
“NMR of large proteins: Molecular chaperones”
Dr. Charalampos G. Kalodimos, Rutgers University
Biophysics Seminar, Room 1300 Chemistry

Friday, December 6, 2013, 4:00
"Structural Gymnastics by Proteins Make the Clock Mechanism Go Around"
Dr. Andy LiWang, University of California, Merced
Biophysics Seminar, Room 1300 Chemistry

Tuesday, December 3, 2013, 12:00
"Reversible DNA and RNA methylation in biological regulation"
Chuan He, University of Chicago
Biological Chemistry Seminar, North Lecture Hall, Med Sci II
Host: Pat O’Brien, Crystallography

Friday, November 22, 2013, 4:00
“Facile NMR Structure Determination of Human Membrane Proteins”
Senyon Choe, Structural Biology Laboratory, Salk Institute
Biophysics Seminar, Room 1300 Chemistry

Tuesday, October 29, 2013, 12:00
"CTD: A Combinatorial code for Transcription Regulation"
Jessie Zhang, University of Texas-Austin
Biological Chemistry Seminar, North Lecture Hall, Med Sci II
Host: John Tesmer, Crystallography

Wednesday, October 23, 2013, 12:00
Keith Wilkinson, Emory University
Pharmacology Seminar, 2736 FSSC, Med Sci II
Host: Matthew Young

Friday, September 20, 2013, 4:00
"Stochastic simulations of cellular processes: from single cells to colonies"
Zaida (Zan) Luthey-Schulten, Univ of IL/Urbana-Champaign
Biophysics Seminar, 1300 Chemistry