Maillard publications


Articles (2010-present)

Maillard I. Inside Blood: Ikaros, Notch and GATA1 cross paths during megakaryopoiesis. Blood, 121(13): 2376-2377, 2013.

Hassan KA, Wang L, Korkaya H, Chen G, Maillard I, Beer DG, Kalemkerian GP, Wicha MS. Notch pathway activity identifies cells with cancer stem cell-like properties and correlates with worse survival in lung adenocarcinoma. Clin Cancer Res. 19(8): 1972-1980, 2013. PubMed link

Rakowski LA, Garagiola DD, Li CM, Decker M, Caruso S, Jones M, Kuick R, Cierpicki T, Maillard I, Chiang MY. Convergence of the ZMIZ1 and NOTCH 1 pathways at C-MYC in acute T lymphoblastic leukemias. Cancer Res, 73(2):930-41, 2013. PubMed link

Chung J, Maillard I. Notch signaling in alloreactive T cell immunity. Curr Top Microbiol Immunol, 360:135-50, 2012. PubMed link

Ku CJ, Hosoya T, Maillard I, Engel JD. GATA-3 regulates hematopoietic stem cell maintenance and cell cycle entry. Blood, 119(10):2242-51, 2012. PubMed link

Shimizu-Hirota R, Xiong W, Baxter BT, Kunkel SL, Maillard I, Chen XW, Sabeh F, Liu R, Li XY, Weiss SJ. MT1-MMP regulates the PI3Kõ•Mi-2/NuRD-dependent control of macrophage immune function. Genes Dev, 26(4):395-413, 2012. PubMed link

Pan X, Jones M, Jiang J, Zaprazna K, Yu D, Pear W, Maillard I, Atchison ML. Increased expression of PcG protein YY1 negatively regulates B cell development while allowing accumulation of myeloid cells and LT-HSC cells. PLoS One, 7(1)e30656, 2012. PubMed link

Sandy AR, Jones M, Maillard I. Notch signaling and development of the hematopoietic system. Adv Exp Med Biol, 727:71-88, 2012. PubMed link

VanDussen KL, Carulli AJ, Keeley TM, Patel SR, Puthoff BJ, Magness ST, Tran IT, Maillard I, Siebel C, Kolterud A, Grosse AS, Gumucio DL, Ernst SA, Tsai YH, Dempsey PJ, Samuelson LC. Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells. Development, 139(3):488-97, 2012. PubMed link

Tan J, Jones M, Koseki H, Nakayama M, Muntean AG, Maillard I, Hess JL. CBX8, a polycomb group protein, is essential for MLL-AF9-induced leukemogenesis. Cancer Cell, 20(5):563-75, 2011. PubMed link

Toubai T, SunY, Tawara I, Friedman A, Liu C, Evers R, Nieves E, Malter C, Chockley P, Maillard I, Winandy S, Reddy P. Ikaros-Notch axis in host hematopoietic cells regulates experimental graft-versus-host disease. Blood, 118(1):192-204, 2011. PubMed link

Jo SY, Granowicz EM, Maillard I, Thomas D, Hess JL. Requirement for Dot1l in murine postnatal hematopoiesis and leukemogenesis by MLL translocation. Blood, 117(18):4759-68, 2011. PubMed link

Zhang Y, Sandy AR, Wang J, Radojcic V, Shan GT, Tran IT, Friedman A, Kato K, He S, Cui S, Hexner E, Frank DM, Emerson SG, Pear WS, Maillard I. Notch signaling is a critical regulator of allogeneic CD4+ T cell responses mediating graft-versus-host disease. Blood, 117(1):299-308, 2011. PubMed link

Aster JC, Bodnar N, Xu L, Karnell F, Milholland JM, Maillard I, Histen G, Nam Y, Blacklow SC, Pear WS. Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation. PLoS One, 6(10):e25645, 2011.

Hosoya T, Maillard I, Engel JD. From the cradle to the grave: activities of GATA-3 thoughout T cell development and differentiation. Immunol Rev. 238(1):110-25, 2010. PubMed link

Articles (2005-2009)

Hosoya T, Kuroha T, Moriguchi T, Cummings D, Maillard I, Lim KC, Engel JD. GATA-3 is required for early T lineage progenitor development. J Exp Med. 206(13):2987-3000, 2009. PubMed link

Sandy, AR, Maillard I. Notch signaling in the hematopoietic system. Expert Opin Biol Ther. 9(11):1383-1398, 2009. PubMed link

Lumeng CN, Maillard I, Saltiel AR. T-ing up inflammation in fat. Nat Med. 15(8):846-7, 2009. PubMed link

Maillard I., Chen YC, Friedman A, et el. Menin regulates the function of hematopoietic stem cells and lymphoid progenitors. Blood, 113(8):1661-69, 2009. PubMed link

Maillard I, Hess J. The role of menin in hematopoiesis. Adv Exp Med Biol. 668:51-7, 2009. PubMed link

Mercher T, Cornejo MG, Sears C, Kindler T, Moore SA, Maillard I, Pear WS, Aster JC, Gilliland DG. Notch signaling specifies megakaryocyte development from hematopoietic stem cells. Cell Stem Cell, 3(3):314-26, 2008. PubMed link

Maillard I., U. Koch, A. Dumortier, O. Shestova, L. Xu, H. Sai, S.E. Pross, J.C. Aster, A. Bhandoola, F. Radtke and W.S. Pear. Canonical Notch signaling is dispensable for the maintenance of adult hematopoietic stem cells. Cell Stem Cell, 2(4), 356-366, 2008. PubMed link

Guo Y., I. Maillard, S. Chakraborti, E.V. Rothenberg and N.S. Speck. Core binding factors are necessary for natural killer cell development, and cooperate with Notch signaling during T cell specification. Blood, epub ahead of print, 2008. PubMed link

Santos M.A., L.M. Sarmento, M. Rebelo, A.A. Doce, I. Maillard, A. Dumortier, H. Neves, F. Radtke, W.S. Pear, L. Parreira and J. Demengeot. Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells. Proc. Natl. Acad. Sci. USA, 104(39):15454-15459, 2007. PubMed link

Wu L.*, I. Maillard*, M. Nakamura, W.S. Pear and J.D. Griffin. The transcriptional co-activator Maml1 is required for Notch2-mediated marginal zone B cell development. Blood, 110(10):3618-23, 2007 (*equal contribution). PubMed link

I. Maillard and W.S. Pear. Keeping a tight leash on Notch. Science, 316:840-842, 2007. Science summary

Zediak V.P., I. Maillard, and A. Bhandoola. Multiple pre-thymic defects underlie age-related loss of T progenitor competence. Blood, 110:1161-7, 2007. PubMed link

Schwarz B.A., A. Sambandam, I. Maillard, B.C. Harman, P.E. Love and A. Bhandoola. Selective thymus settling regulated by cytokine and chemokine receptors. J. Immunol., 178:2008-17, 2007. PubMed link

Thomas M., M. Calamito, B. Srivastava, I. Maillard, W.S. Pear and D. Allman. Notch activity synergizes with B cell receptor and CD40 signaling to enhance B cell activation. Blood, 109:3342-50, 2006. PubMed link

K. Keeshan, Y. He, B.J. Wouters, O. Shestova, H. Sai, C.G. Rodriguez, I. Maillard, J.W. Tobias, P. Valk, M. Carroll, J.C. Aster, R. Delwel and W.S. Pear. Tribbles homolog 2 (Trib2) inactivates C/EBP alpha and causes acute myelogenous leukemia. Cancer Cell, 10(5): 401-11, 2006. PubMed link

L. Talebian, Z. Li, Y. Guo, J. Gaudet, M.E. Speck, D. Sugiyama, P. Kaur, W.S. Pear, I. Maillard* and N.A. Speck*. T lymphoid, megacaryocyte, and granulocyte development are sensitive to decreases in CBFbeta dosage. Blood, 1;109(1): 11-21, 2006 (*corresponding authors). PubMed link

Maillard I., L. Tu, A. Sambandam, Y. Yashiro-Ohtani, J. Millholland, K. Keeshan, O. Shestova, L. Xu, A. Bhandoola and W.S. Pear. The requirement for Notch signaling at the beta selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. J. Exp. Med., 203(10): 2239-45, 2006. PubMed link

Maillard I., B. Schwarz, A. Sambandam, T. Fang, O. Shestova, L. Xu, A. Bhandoola and W.S. Pear. Notch-dependent T lineage commitment occurs at extrathymic sites following bone marrow transplantation. Blood, 107(9): 3511-19, 2006. PubMed link

Tu L., T.C. Fang, D. Artis, O. Shestova, S.E. Pross, I. Maillard and W.S. Pear. Notch signaling is an important regulator of type 2 immunity. J. Exp. Med., 202(8):1037-42, 2005. PubMed link

Zediak V.P., I. Maillard and A. Bhandoola. Closer to the source: Notch and the nature of thymus settling cells. Immunity, 23(3): 245-48, 2005. PubMed link

Sambandam A.*, I. Maillard*, V.P. Zediak, L. Xu, R.M. Gerstein, J.C. Aster, W.S. Pear and A. Bhandoola. Notch signaling controls the generation and differentiation of early T lineage progenitors. Nature Immunology, 6(7):663-70, 2005 (*equal contribution). PubMed link

Maillard I., T. Fang and W.S. Pear. Regulation of lymphoid development, differentiation and function by the Notch pathway. Annu Rev Immunol, 23:945-974, 2005. PubMed link

Articles (2000-2004)

Kumar R., I. Maillard, S.J. Schuster and A. Alavi. Utility of fluorodeoxyglucose-PET imaging in the management of patients with Hodgkin's and non-Hodgkin's lymphomas. Radiol Clin North Am, 42(6):1083-100, 2004. PubMed link

Maillard I., A.P. Weng, A.C. Carpenter, C.G. Rodriguez, H. Sai, L. Xu, D. Allman, J.C. Aster, and W.S. Pear. Mastermind critically regulates Notch-mediated lymphoid cell fate decisions. Blood, 104(6):1696-702, 2004. PubMed link

Maillard I., S.H. Adler and W.S. Pear. Notch and the immune system. Immunity, 19(6): 781-91, 2003. PubMed link

D.E. Tsai, I. Maillard, L. Downs, A. Alavi, S.D. Nasta, E.A. Stadtmauer, D.L. Porter, T.R. Klumpp, S.M. Luger and S.J. Schuster. Use of Iodine 131I Tositumomab Radioimmunotherapy in a Patient with Waldenstrom's Macroglobulinemia. Leuk Lymphoma, 45(3): 591-595, 2004. PubMed link

Tsai D.E., I. Maillard, S.J. Schuster, S.D. Nasta, D.L. Porter, T.R. Klumpp, D.M. Goldenberg, S.M. Luger, A. Alavi, R.M. Sharkey, K.B. Hartzell and E.A. Stadtmauer. Use of ibritumomab tiuxetan anti-CD20 radioimmunotherapy in a non-Hodgkin's lymphoma patient previously treated with a yttrium-90-labeled anti-CD22 monoclonal antibody. Clin Lymphoma 4(1): 56-9, 2003. PubMed link

Maillard I., Y. He and W.S. Pear. From the yolk sac to the spleen: new roles for Notch in regulating hematopoiesis. Immunity 18(5): 587-589, 2003. PubMed link

Maillard I. and W.S. Pear. Notch and cancer: Best to avoid the ups and downs. Cancer Cell 3(3):203-5, 2003. PubMed link

Allenspach E.J., I. Maillard, J.C. Aster and W.S. Pear. Notch signaling in cancer. Cancer Biol. Ther. 1(5):466-76, 2002. PubMed link

Stupp R., P.Y. Dietrich, S. Ostermann Kraljevic, A. Pica, I. Maillard, P. Maeder, R. Meuli, R. Janzer, G. Pizzolatto, R. Miralbell, F. Porchet, L. Regli, N. de Tribolet, R.O. Mirimanoff and S. Leyvraz. Promising survival for patients with newly diagnosed glioblastoma multiforme treated with concomitant radiation plus temozolomide followed by adjuvant temozolomide. J. Clin. Oncol. 20(5):1375-1382, 2002. PubMed link

Baribaud F., S. Wirth, I. Maillard, S. Valsesia, H. Acha-Orbea and H. Diggelmann. Identification of key amino acids of the mouse mammary tumor virus superantigen involved in the specific interaction with T-cell receptor V beta domains. J. Virol. 75(16):7453-6, 2001. PubMed link

Maillard I., P. Launois, H. Himmelrich, H. Acha-Orbea, H. Diggelmann, R.M. Locksley and J.A. Louis. Functional plasticity of the LACK-reactive Vbeta4-Valpha8 CD4+ T cells normally producing the early IL-4 instructing Th2 cell development and susceptibility to Leishmania major infection in BALB/c mice. Eur. J. Immunol. 31(4):1288-96, 2001. PubMed link

Maillard I., V. Schweizer, A. Broccard, A. Duscher, L. Liaudet and M.D. Schaller. Use of botulinum toxin type A to avoid tracheal intubation or tracheostomy in severe paradoxical vocal cord movement. Chest 118(3), 874-7, 2000. PubMed link

Nishino I., A. Spinazzola, A. Papadimitriou, S. Hammans, I. Steiner, C.D. Hahn, A.M. Connolly, A. Verloes, J. Guimaraes, I. Maillard et al. Mitochondrial neurogastrointestinal encephalomyopathy: an autosomal recessive disorder due to thymidine phosphorylase mutations. Ann. Neurol. 47(6), 792-800, 2000. PubMed link

Himmelrich H., P. Launois, I. Maillard, T. Biedermann, F. Tacchini-Cottier, R.M. Locksley, M. Rocken and J.A. Louis. In BALB/c mice, IL-4 production during the initial phase of infection with Leishmania major is necessary and sufficient to instruct Th2 cell development resulting in progressive disease. J. Immunol. 164(9), 4819-25, 2000. PubMed link

Articles (1996-1999)

Baribaud F., I. Maillard, S. Vacheron, T. Brocker, H. Diggelmann and H. Acha-Orbea. Role of dendritic cells in the immune response induced by mouse mammary tumor virus superantigen. J. Virol. 73(10): 8403-10, 1999. PubMed link

Maillard I., I. Xenarios, H. Diggelmann, and H. Acha-Orbea. Differential reactivity of TCR Vbeta10 alleles to a mouse mammary tumor virus superantigen. Eur. J. Immunol. 28: 3075-3085, 1998. PubMed link

Maillard I., F. Luthi, H. Acha-Orbea and H. Diggelmann. Role of the immune response induced by superantigens in the pathogenesis of microbial infections. Parasitology 115: S67-S78, 1997. PubMed link

Maillard I., P. Launois, I. Xenarios, J. A. Louis, H. Acha-Orbea, and H. Diggelmann. Immune response to mouse mammary tumor virus in mice lacking the alpha/beta interferon or the gamma interferon receptor. J. Virol. 72: 2638-2646, 1998. PubMed link

P. Launois, I. Maillard, S. Pingel, K.G. Swihart, I. Xenarios, H. Acha-Orbea, H. Diggelmann, R.M. Locksley, H.R. MacDonald, and J.A. Louis. IL-4 rapidly produced by Vbeta4 Valpha8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immunity 6: 541-549, 1997. PubMed link

Luther, S. A., I. Maillard, F. Luthi, L. Scarpellino, H. Diggelmann, and H. Acha-Orbea. Early neutralizing antibody response against mouse mammary tumor virus: critical role of viral infection and superantigen-reactive T cells. J. Immunol. 159: 2807-2814, 1997. PubMed link

Maillard I., K. Erny, H. Acha-Orbea, and H. Diggelmann. A Vbeta4-specific superantigen encoded by a new exogenous mouse mammary tumor virus. Eur. J. Immunol. 26: 1000-1006, 1996. PubMed link