Zhouhui Xu

Our Research

Our lab uses a multi-disciplinary approach of structural biology, biochemistry and cell biology to study molecular mechanisms of proteins that function in intracellular trafficking.

Our current focus is on the endosomal-sorting complex required for transport (ESCRT), a multi-component protein machinery essential for a wide range of biological processes including cell surface receptor down-regulation, enveloped virus budding, cytokinesis and autophagy. Our work has therapeutic implications for diseases such as cancer, viral infection and neuro-degeneration.

About Zhaohui Xu

Specialties:
  • Structural biology
  • Protein folding
  • Molecular chaperones

Zhaohui Xu uses structural biology to study molecular "chaperones" that help proteins fold into the proper shape and get to the right place inside the cell. His work has therapeutic implications for everything diabetes, high cholesterol, mad cow disease, Alzheimer's and Parkinson's.

Research Highlight

Our current focus is on the endosomal-sorting complex required for transport (ESCRT), a multi-component protein machinery essential for a wide range of biological processes including cell surface receptor down-regulation, enveloped virus budding, cytokinesis and autophagy.

Recent Publications

Chen, X.-W., Leto, D., Xiao, J., Goss, J., Wang, Q., Shavit, J. A., Xiong, T., Yu, G., Ginsburg, D., Toomre, D., Xu, Z., and Saltiel, A. R. (2011) Exocyst function is regulated by effector phosphorylation. Nat. Cell Biol., 13, 580-588.

Quan, S., Koldewey, P., Tapley, T., Kirsch, N., Ruane, K.M., Pfizenmaier, J., Shi, R., Hofmann, S., Foit, L., Ren, G., Jakob, U., Xu, Z., Cygler, M., and Bardwell, J.C. (2011) Genetric selection designed to stabilize proteins uncovers a chaperone called Spy. Nat. Struct Mol Biol., 18, 262-269.