Yukiko Yamashita

Our Research

Adult stem cells continuously supply highly differentiated cells throughout life. The daughters of stem cell division have two possible fates: stem cell self-renewal or differentiation. A balance between these cell populations is critical, as an excess of stem cell self-renewal can lead to tumorgenesis, whereas an excess of differentiation can deplete the stem cell pool.

Our lab seeks to understand the mechanisms that regulate asymmetric stem cell division, as they are poorly understood.

About Yukiko Yamashita

  • Stem cells
  • Developmental biology
  • Cell division and differentiation

Yukiko Yamashita uses Drosophila as a model system to investigate a fundamental question: When stem cells divide, what determines which daughter cell will remain a stem cell and which will differentiate into another tissue type?

Explore and Discover

We are broadly interested in mysteries of biology, with our current interests covering the following areas:
-Mechanisms of asymmetric cell division
-Roles of satellite DNAs
-Germ cells

Recent Publications

Inaba M, Buszczak M, Yamashita YM. (2015) Nanotubes mediate niche–stem-cell signalling in the Drosophila testis. Nature. doi:10.1038/nature14602

Yang H, Yamashita YM. (2015) The regulated elimination of transit-amplifying cells preserves tissue homeostasis during protein starvation in Drosophila testis. Development. 142:1756-1766

Inaba M, Venkei ZG, Yamashita YM. (2015) The polarity protein Baz forms a platform for the centrosome orientation during asymmetric stem cell division in the Drosophila male germline. Elife. doi: 10.7554/eLife.04960

Venkei ZG, Yamashita YM. (2015) The centrosome orientation checkpoint is germline stem cell specific and operates prior to the spindle assembly checkpoint in Drosophila testis. Development. 142:62-69.