Yukiko Yamashita

Our Research

Adult stem cells continuously supply highly differentiated cells throughout life. The daughters of stem cell division have two possible fates: stem cell self-renewal or differentiation. A balance between these cell populations is critical, as an excess of stem cell self-renewal can lead to tumorgenesis, whereas an excess of differentiation can deplete the stem cell pool.

Our lab seeks to understand the mechanisms that regulate asymmetric stem cell division, as they are poorly understood.

About Yukiko Yamashita

  • Stem cells
  • Developmental biology
  • Cell division and differentiation

Yukiko Yamashita uses Drosophila as a model system to investigate a fundamental question: When stem cells divide, what determines which daughter cell will remain a stem cell and which will differentiate into another tissue type?

Explore and Discover

We are broadly interested in mysteries of biology, with our current interests covering the following areas:
-Mechanisms of asymmetric cell division
-Roles of satellite DNAs
-Germ cells

Recent Publications

Lu KL, Nelson JO, Watase GJ, Warsinger-Pepe N, Yamashita YM (2018) Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells. Elife. 2018 Feb 13;7. pii: e32421. doi: 10.7554/eLife.32421. PubMed PMID: 29436367.

Lu KL, Yamashita YM. (2017) Germ cell connectivity enhances cell death in response to DNA damage in the Drosophila testis. Elife. Aug 15;6. pii: e27960. doi:10.7554/eLife.27960. PubMed PMID: 28809158.

Chen C, Inaba M, Venkei ZG, Yamashita YM. (2016) Klp10A, a stem cell centrosome-enriched kinesin, balances asymmetries in Drosophila male germline stem cell division. Elife. 2016 Nov 25;5. pii: e20977. doi: 10.7554/eLife.20977. PubMed PMID: 27885983.