Yukiko Yamashita

Our Research

Adult stem cells continuously supply highly differentiated cells throughout life. The daughters of stem cell division have two possible fates: stem cell self-renewal or differentiation. A balance between these cell populations is critical, as an excess of stem cell self-renewal can lead to tumorgenesis, whereas an excess of differentiation can deplete the stem cell pool.

Our lab seeks to understand the mechanisms that regulate asymmetric stem cell division, as they are poorly understood.

About Yukiko Yamashita

  • Stem cells
  • Developmental biology
  • Cell division and differentiation

Yukiko Yamashita uses Drosophila as a model system to investigate a fundamental question: When stem cells divide, what determines which daughter cell will remain a stem cell and which will differentiate into another tissue type?

Explore and Discover

We are broadly interested in mysteries of biology, with our current interests covering the following areas:
-Mechanisms of asymmetric cell division
-Roles of satellite DNAs
-Germ cells

Recent Publications

Jagannathan M, Warsinger-Pepe N, Watase GJ, Yamashita YM. (2017) Comparative Analysis of Satellite DNA in the Drosophila melanogaster Species Complex. G3 (Bethesda). 7(2):693-704. doi: 10.1534/g3.116.035352. PubMed PMID: 28007840;PubMed Central PMCID: PMC5295612.

Chen C, Inaba M, Venkei ZG, Yamashita YM. (2016) Klp10A, a stem cell centrosome-enriched kinesin, balances asymmetries in Drosophila male germline stem cell division. Elife. 2016 Nov 25;5. pii: e20977. doi: 10.7554/eLife.20977. PubMed PMID: 27885983.

Inaba M, Buszczak M, Yamashita YM. (2015) Nanotubes mediate niche–stem-cell signalling in the Drosophila testis. Nature. doi:10.1038/nature14602. PubMed PMID: 26131929; PubMed Central PMCID: PMC4586072.