Stephen Weiss

Our Research

Normal and neoplastic cells are surrounded by a dense, fibrillar composite of extracellular matrix molecules that not only serve as a platform for cell adhesion, but also exert complex effects on cell differentiation, fate and function.

Our laboratory focuses on the characterization of both the proteolytic enzymes and the transcriptional programs that control extracellular matrix remodeling during growth and development, inflammation and cancer.

About Stephen Weiss

Specialties:
  • Cancer
  • Metastasis

Dr. Weiss's research efforts focus on the mechanisms used by cancer cells, immune cells, stromal cells and the vascular network to remodel tissue structure during events ranging from cancer and inflammation to angiogenesis and metastasis. By applying new insights into the molecular machinery that controls tissue remodeling programs, Weiss is designing novel targets and therapeutics for diseases from cancer to obesity and rheumatoid arthritis.

Weiss highlight

Normal as well as neoplastic cells are surrounded by a dense, fibrillar composite of extracellular matrix molecules that not only serve as a platform for cell adhesion, but also exert complex effects on cell differentiation, fate and function. The Weiss laboratory focuses on the characterization of both the proteolytic enzymes and the transcriptional programs that control extracellular matrix remodeling during growth and development, inflammation and cancer.

Recent publications

Lin, Y., Li, X-Y., Willis, A.L., Liu, C., Chen, G. and S.J. Weiss. Snail-dependent control of embryonic stem cell pluripotency and lineage commitment. Nat Communications, 2014, 5:3070.

Tang, Y., Rowe, R.G., Botvinick, E.L., Kurup, A., Putnam, A.J., Seiki, M., Weaver, V.M.,Keller, E.T., Goldstein, S.A., Begun, D., Dai, J., Saunders, T.L. and S.J. Weiss. Control of Mesenchymal Stem Cell Commitment by an MT1-MMP/YAP/TAZ Mechanotransduction Axis. Developmental Cell, 2013, 25:402–416.

Shimizu-Hirota, R., Xiong, W., Baxter, B.T., Kunkel, S.L., Maillard, I., Chen, X.-Y., Sabeh, F., Liu, R., Li, X.-Y., and S.J. Weiss. MT1-MMP-dependent regulation of a PI3Kd-nucleosome remodeling axis controls macrophage immune function. Genes & Development, 2012, 26:395-413.