We are a research team that is trying to understand the molecular details that determine how, where, and when motor proteins transport intracellular cargo. Our research program focuses on the structural biology and biophysics underlying microtubule-based intracellular transport through the use of cryo-electron microscopy, single molecule TIRF, and biochemistry.
Overarching questions of the lab:
- How is specificity determined between motor proteins and cargo?
- How are the activities of multi-motor complexes regulated?
- What are the molecular consequences of neurodegenerative disease-causing mutations?
Along the way, we are also developing cloud computing tools for cryo-electron microscopy to facilitate its adoption and to remove barriers for new users.