Melanie Ohi

Our Research

Our lab is interested in understanding how large molecular machines are structurally organized and how this organization translates into function within the cell. We use single particle cryo-electron microscopy, as well as a combination of biological and biochemical techniques to pursue this goal.

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About Melanie Ohi

Research Associate Professor
  • cryo-electron microscopy
  • genetics
  • biochemistry


Melanie Ohi's reserach focuses on dissecting the structural and functional organization of the spliceosome, generating mechanistic models for how pore-forming toxins secreted by pathogenic bacteria transition from soluble to membrane inserted states, and studying the ways proteins can structurally influence membrance organization.

Lab News

The Ohi lab joined the LSI on Sept. 1, 2017.

Recent Publications