Lois Weisman

Our Research

The Weisman lab uses yeast to study neurodegeneration and cancer, with the goal of determining the mechanisms of myosin V based transport and phosphoinositide signaling. The ultimate goal is to develop novel therapies for relevant diseases.

Our group uses aspects of biochemistry, molecular biology, cell biology, genetics and developmental biology to discover how cells function.

About Lois Weisman

  • Neurodegeneration
  • Organelles

Lois Weisman researches the underlying causes of neurodegeneration and other neurological diseases, of which little is known. Her work focuses on myosin V based transport and phosphoinositide lipid signaling in yeast and neurons, with the overall goal of uncovering new, essential subcellular processes and to determine how these impact human physiology.

Research highlight: Signaling lipids and neuronal communication

The Weisman lab outlined the mechanisms by which the brain makes two important signaling lipids and determined what roles those lipids play in neuronal communication. Improper levels of the lipids can cause severe neurological problems, such as a type of Charcot-Marie-Tooth disorder, one of the most common hereditary neurological disorders, and some motor neuron diseases, including some cases of amyotrophic lateral sclerosis (also called Lou Gehrig’s disease).
The research was published in October 2012 in the Proceedings of the National Academy of Science.

Recent publications

 McCartney, A., Zolov, S.N., Kauffman, E.J., Strunk, B.S., Zhang, Y., Weisman, L.S. and Sutton, M. (2014) Activity-dependent PI(3,5)P2 synthesis controls AMPA receptor trafficking during synaptic depression. PNAS  111:E4896-4905.PMCID:PMC4234577 in process. PNAS link

Jin N., Mao K., Jin Y., Tevzade G., Kauffman E.J., Park S., Bridges D., Loewith R., Saltiel A.R., Klionsky D.J., Weisman L.S. (2014) Roles for PI3,5P2 in nutrient sensing through TORC1. Mol. Biol. Cell,  25:1171-1185. PMCID: PMC3967979. PubMed link

Yau, R.G.W., Peng, Y., Valiathan, R., Birkeland, S.R., Wilson, T.E. and Weisman, L.S. (2014) Release from myosin V via spatially regulated recruitment of an E3 Ub ligase controls organelle localization. Dev Cell,  28:520-533. PMCID: PMC3994899. PubMed link