Our lab studies the molecular basis of G protein-coupled receptor (GPCR)-mediated signal transduction, principally via the technique of X-ray crystallography. GPCRs are responsible for the sensations of sight and smell, for regulation of blood pressure and heart rate, and for many other cellular events. By determining atomic structures of these signaling proteins both alone and in complex with their various targets, we provide important insights into the molecular basis of signal transduction and of diseases that emerge as a result of dysfunctional signaling.
- X-ray crystallography
- Cardiovascular therapeutics
John Tesmer is a structural biologist who investigates a particular class of protein molecules that carry signals transduced across the membranes of cells, called G proteins. This mechanism of cell-to-cell communication is required for the sensations of sight and smell, for regulation of blood pressure and heart rate, and for many other physiological events.
Most cancer drugs today work by attacking tumor growth. Researchers at the University of Michigan Life Sciences Institute, however, are taking aim at a different piece of the cancer puzzle—preventing its ability to spread to new parts of the body, known as metastasis, which is the cause of most cancer deaths.
Azevedo AW, Doan T, Moaven H, Sokal I, Baameur F, Vishnivetskiy SA, Homan KT, Tesmer JJG, Gurevich VV, Chen J, Rieke F: C-terminal threonines and serines play distinct roles in the desensitization of rhodopsin, a G protein-coupled receptor. Elife 2015;4. doi: 10.7554/eLife.05981. PMCID: in process.PubMed Link
Li L, Homan KT, Vishnivetskiy SA, Manglik A, Tesmer JJG, Gurevich VV, Gurevich EV. G protein-coupled receptor kinases of the GRK4 subfamily phosphorylate inactive GPCRs. J. Biol. Chem. 2015, 290: 10775-90. PMCID: 4409243 PubMedLink
Glukhova A, Hinkovska-Galcheva V, Kelly R, Abe A, Shayman JA, Tesmer JJG: Structure and function of lysosomal phospholipase A2 and lecithin: cholesterol acyltransferase. Nat. Commun.2015, 6:6250. doi: 10.1038/ncomms7250. PMCID: 4397983 PubMed Link