The Maillard laboratory is interested in the study of blood-forming stem cells, blood cell development and the development and function of T lymphocytes.
Our research is devoted to the following main topics: 1) Understanding the role of Notch signaling in the regulation of T cell homeostasis and differentiation, particularly in the setting of allogeneic T cell responses; 2) investigating the homeostasis of blood-forming stem cells in situations of hematopoietic stress and the role of epigenetic regulation in their regulation.
In a first project, we are interested in the regulation of mature T cell homeostasis and differentiation by Notch signaling. Using several genetic models of Notch inactivation, we are investigating the molecular and cellular mechanisms underlying the activity of Notch signaling in allogeneic T cell responses (T cell responses against foreign tissue antigens). Our findings indicate that Notch behaves as a novel and potent master regulator of T cell function in several mouse models of graft-versus-host disease. We are currently investigating the molecular mechanisms of this effect and exploring its potential therapeutic applications.