Georgios Skiniotis

Our Research

The Skiniotis lab is interested in the 3D visualization of protein nanomachines aiming to elucidate mechanistic aspects of their operation, primarily through the application of cryo-electron microscopy (cryo-EM), currently the only technique that allows direct visualization of biological complexes at the molecular level.

Meet our team:

Our technology platform:

About Georgios Skiniotis

  • structural biology
  • cryo-EM
  • cell surface receptors

Georgios Skiniotis is the Jack E. Dixon Professor at the Life Sciences Institute and an Associate Professor of Biological Chemistry at the University of Michigan Medical School.

Recent Publications

Dutta S, Whicher JR, Hansen DA, Hale WA, Chemler JA, Congdon GR, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. (2014). Structure of a modular polyketide synthase. Nature.

Whicher JR, Dutta S, Hansen DA, Hale WA, Chemler JA, Dosey AM, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis, G. (2014). Structural rearrangements of a polyketide synthase module during its catalytic cycle. Nature.

Shukla AK, Westfield GH, Xiao K, ... Kobilka BK.+, Skiniotis G.+ & Lefkowitz RJ.+ (2014). Visualization of arrestin recruitment by a G Protein-Coupled Receptor. Nature.

Nature's Chem Lab

The Skiniotis lab applied cryo-EM to create the first three-dimensional snapshots of the “assembly line” within microorganisms that naturally produces antibiotics and other drugs. Understanding the complete structure and movement within the molecular factory gives investigators a solid blueprint for redesigning the microbial assembly line to produce novel drugs of high medicinal value.