Georgios Skiniotis

Our Research

Our scientific presence evolves around the 3D visualization of protein nanomachines and the deconvolution of mechanistic aspects of their operation. This has been primarily accomplished through the application of molecular electron microscopy (cryo-EM and negative stain EM), currently the only technique that allows direct visualization of biological complexes at the molecular level.

Meet our team:

Our technology platform:

About Georgios Skiniotis

  • structural biology
  • cryo-EM
  • cell surface receptors

Georgios (a.k.a. Yiorgo) Skiniotis is a Pew Scholar of Biomedical Sciences and an Associate Professor of Biological Chemistry at the University of Michigan Medical School.

Research Highlight: Red Sea

The Life Sciences Institute's David Sherman explores biochemical pathways of marine microorganisms to find new drug candidates to treat infectious diseases and cancers. To collect the samples he needs for his work, he often trades his lab coat for a wet suit and travels to exotic locations rich in biodiversity resources. In November 2014, Sherman traveled with fellow LSI faculty member and frequent collaborator Georgios Skiniotis, a structural biologist, to Saudi Arabia to collect marine microorganisms from the Red Sea.

Recent Publications

Dutta S, Whicher JR, Hansen DA, Hale WA, Chemler JA, Congdon GR, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. (2014). Structure of a modular polyketide synthase. Nature.

Whicher JR, Dutta S, Hansen DA, Hale WA, Chemler JA, Dosey AM, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis, G. (2014). Structural rearrangements of a polyketide synthase module during its catalytic cycle. Nature.

Shukla AK, Westfield GH, Xiao K, ... Kobilka BK✚, Skiniotis G✚ & Lefkowitz RJ✚. (2014). Visualization of arrestin recruitment by a G Protein-Coupled Receptor. Nature.