Georgios Skiniotis

Our Research

The Skiniotis lab creates 3D visualizations of protein nanomachines and elucidates mechanistic aspects of their operation, primarily through the application of molecular electron microscopy (cryo-EM and negative stain EM), currently the only techniques that allows direct visualization of biological complexes at the molecular level.

Meet our team: www.lsi.umich.edu/skiniotis-lab/lab-members

Our technology platform: www.lsi.umich.edu/cryo-em

About Georgios Skiniotis

Specialties:
  • structural biology
  • cryo-EM
  • cell surface receptors

Georgios Skiniotis is the Jack E. Dixon Professor at the Life Sciences Institute, an Associate Professor of Biological Chemistry at the University of Michigan Medical School and a Pew Scholar of Biomedical Sciences.

Recent Publications

Dutta S, Whicher JR, Hansen DA, Hale WA, Chemler JA, Congdon GR, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis G. (2014). Structure of a modular polyketide synthase. Nature.

Whicher JR, Dutta S, Hansen DA, Hale WA, Chemler JA, Dosey AM, Narayan AR, Håkansson K, Sherman DH, Smith JL, Skiniotis, G. (2014). Structural rearrangements of a polyketide synthase module during its catalytic cycle. Nature.

Shukla AK, Westfield GH, Xiao K, ... Kobilka BK.+, Skiniotis G.+ & Lefkowitz RJ.+ (2014). Visualization of arrestin recruitment by a G Protein-Coupled Receptor. Nature.

Nature's Chem Lab

The Skiniotis lab applied cryo-EM to create the first three-dimensional snapshots of the “assembly line” within microorganisms that naturally produces antibiotics and other drugs. Understanding the complete structure and movement within the molecular factory gives investigators a solid blueprint for redesigning the microbial assembly line to produce novel drugs of high medicinal value.