Composed of a dynamic, interdisciplinary team of scientists, the Sherman laboratory studies the biosynthesis of natural products from microbes that include cyanobacteria, actinomycetes, and myxobacteria. We are inspired by natural products from both terrestrial and marine organisms and seek to better understand their origins using a set of tools that includes molecular biology, genetics, biochemistry, structural biology, and bioorganic chemistry.
- Synthetic chemistry
- Marine microorganisms
- Drug discovery
David Sherman explores the biochemical pathways of marine microorganisms with the goal of finding new drug candidates for infectious diseases and cancers. He collects samples from marine and terrestrial sources around the world to build an extensive library of natural chemical compounds with potential disease-fighting capability.
Lowell, A.N., DeMars, M.D., Slocum, S.T., Yu, F., Anand, K., Chemler, J.A., Korakavi, N., Priessnitz, J.K., Park, S.R., Koch, A.A., Schultz, P.J., Sherman, D.H. 2017. Chemoenzymatic total synthesis and structural diversification of tylactone-based macrolide antibiotics through late-stage polyketide assembly, tailoring, and C-H functionalization. J. Am. Chem. Soc. 139: 7913−7920. PubMed link
Koryakina, I., Kasey, C., McArthur, J. B., Lowell, A. N., Chemler, J. A., Li, S., Hansen, D. A., Sherman, D. H., Williams, G. J. 2017. Inversion of extender unit selectivity in the erythromycin polyketide synthase by acyltransferase domain engineering. ACS Chem. Biol. 12(1):114-123. doi: 10.1021
Li, S., Lowell, A. N., Newmister, S. A., Yu, F., Williams, R. M., Sherman, D. H. 2017. Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids. Nature Chem. Biol. (on-line publication, March 13, 2017). 10.1038/nchembio.2327