Composed of a dynamic, interdisciplinary team of scientists, the Sherman laboratory studies the biosynthesis of natural products from microbes that include cyanobacteria, actinomycetes, and myxobacteria. We are inspired by natural products from both terrestrial and marine organisms and seek to better understand their origins using a set of tools that includes molecular biology, genetics, biochemistry, structural biology, and bioorganic chemistry.
- Synthetic chemistry
- Marine microorganisms
- Drug discovery
David Sherman explores the biochemical pathways of marine microorganisms with the goal of finding new drug candidates for infectious diseases and cancers. He collects samples from marine and terrestrial sources around the world to build an extensive library of natural chemical compounds with potential disease-fighting capability.
Newmister, S. A., Gober, C., Romminger, S., Yu, F., Tripathi, A., Parra, L. L., Williams, R. M., Berlinck, R., Joullié, M., Sherman D. H. 2016. OxaD, a versatile indolic nitrone synthase from the marine derived fungus Penicillium oxalicum F30. J. Amer. Chem. Soc..
DeMars, M. D., Sheng, F., Park, S. R., Lowell, A. N., Podust, L. M., and Sherman, D. H. 2016. Biochemical and structural characterization of MycCI, a versatile P450 biocatalyst from the mycinamicin biosynthetic pathway. ACS Chem. Biol.
Tripathi, A., Choi, S. S., Sherman, D. H., Kim, E. S. 2016. Thioesterase domain swapping of a linear polyketide tautomycetin with a macrocyclic polyketide pikromycin in Streptomyces sp. CK4412. J. Ind. Microbiol. Biotechnol.