Composed of a dynamic, interdisciplinary team of scientists, the Sherman laboratory studies the biosynthesis of natural products from microbes that include cyanobacteria, actinomycetes, and myxobacteria. We are inspired by natural products from both terrestrial and marine organisms and seek to better understand their origins using a set of tools that includes molecular biology, genetics, biochemistry, structural biology, and bioorganic chemistry.
- Synthetic chemistry
- Marine microorganisms
- Drug discovery
David Sherman explores the biochemical pathways of marine microorganisms with the goal of finding new drug candidates for infectious diseases and cancers. He collects samples from marine and terrestrial sources around the world to build an extensive library of natural chemical compounds with potential disease-fighting capability.
In spring 2013, David Sherman and and a team of scientists headed to Isla del Coco, a protected island off the Pacific coast of Costa Rica, to collect marine and terrestrial samples.
Back in the Sherman lab in the LSI, researchers will extract chemical compounds from the samples and screen them for potential use as drugs.
Follow our tumblr for pictures and blogs of our diving experiences.
Walter, G.M., Raveh, A., McQuade, T. J., Arevang, C.J., Schultz, P. J., Smith, M. C., Asare, S., Cruz, P. G., Wisen, S., Matainaho, T., Sherman, D.H ., Gestwicki, J. E. 2014. High throughput screen of natural product extracts in a yeast model of polyglutamine proteotoxicity. Chem. Biol. Drug Des. 83(4):440-449. PubMed link
Negretti, S., Narayan, A.R., Chiou K.C., Kells, P.M., Stachowski, J., Hansen, D., Podust, L., Montgomery, J., Sherman, D.H. 2014. Directing group-controlled regioselcetivity in an enzymatic C-H bond oxygenation. J. Am. Chem. Soc. 136(13):4901-4904. PubMed link
Zhang, W., Liu, Y., Yan, J., Cao, S., Bai, F., Yang, Y., Huang, S., Yao, L., Anzai, Y., Kato, F., Podust, L.M., Sherman, D.H. , Li, S. 2014. New reactions and products resulting from alternative interactions between the P450 enzyme and redox partners. J. Am. Chem. Soc. 136(9):3640-3646. doi: 10.1021/ja4130302. PubMed link
Coates, R.C., Podell, S., Korobeynikov, A., Lapidus, A., Pevzner, P., Sherman, D.H., Allen, E.E., Gerwick, L., Gerwick, W.H. 2014. Characterization of cyanobacterial hydrocarbon composition and distribution of biosynthetic pathways. PLoS One 9(1):e85140 PubMed link