Composed of a dynamic, interdisciplinary team of scientists, the Sherman laboratory studies the biosynthesis of natural products from microbes that include cyanobacteria, actinomycetes, and myxobacteria. We are inspired by natural products from both terrestrial and marine organisms and seek to better understand their origins using a set of tools that includes molecular biology, genetics, biochemistry, structural biology, and bioorganic chemistry.
- Synthetic chemistry
- Marine microorganisms
- Drug discovery
David Sherman explores the biochemical pathways of marine microorganisms with the goal of finding new drug candidates for infectious diseases and cancers. He collects samples from marine and terrestrial sources around the world to build an extensive library of natural chemical compounds with potential disease-fighting capability.
In spring 2013, David Sherman and and a team of scientists headed to Isla del Coco, a protected island off the Pacific coast of Costa Rica, to collect marine and terrestrial samples.
Back in the Sherman lab in the LSI, researchers will extract chemical compounds from the samples and screen them for potential use as drugs.
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Dutta, S., Whicher, J.R., Hansen, D.A., Hale, W.A., Chemler, J.A., Congdon, G.R., Narayan, A.R., Hakansson, K., Sherman, D.H., Smith, J.L., Skiniotis, G. 2014. Structure of a modular polyketide synthase. Nature. 510(7506): 512-517.
Whicher, J.A., Dutta, S., Hansen, D.A., Hale, W.A., Chemler, J.A., Dosey, A.M., Narayan, A.R., Hakansson, K., Sherman, D.H., Smith, J.L., Skiniotis, G. 2014. Structural rearrangements of a polyketide synthase module during its catalytic cycle. Nature. 510(7506):560-564.
Newmister, S.A., Sherman, D.H. 2014. Crystal structures of acyl carrier protein in complex with two catalytic partners show a dynamic role in cellular metabolism. ChemBioChem. 15(8):1079-1081.