Mapp Lab

Our Research

The Mapp research group uses the tools of synthetic organic chemistry, biochemistry, and molecular biology to better understand how genes are regulated.

Projects in the group range from the development of new synthetic methods for preparing complex, optically active structures to manipulating genes in Saccharomyces cerevisiae (yeast) in order to identify key protein-protein interactions in gene activation.

Our group is multidisciplinary with students from the Medicinal Chemistry Program, Program in Chemical Biology, and the Department of Chemistry.

About Anna Mapp

Anna Mapp focuses on developing a molecular-level picture of inducible gene expression in eukaryotes using organic molecules as mechanistic probes. She is also the Director of the Program in Chemical Biology.

Mapp Lab Mission Statement

The Mapp Lab believes that it is only a diverse and inclusive multidisciplinary research culture that enables lab members to work to their highest potential, advance our scientific objectives, and develop the next generation of innovators, scientists, and leaders.

 

Philosophy

 

The Mapp Lab believes that it is only through the unified commitment to and active involvement of each member that a diverse and inclusive environment for all can be created. We assert that members perform best in an environment where they are individually valued, their ideas are heard, and their unique perspectives respected. A culture where everyone feels they belong is our greatest strength in sustaining our intellectual and creative pursuits.

Recent publications

Dugan A, Majmudar CY, Pricer R, Niessen S, Lancia JK, Fung HY, Cravatt BF, Mapp AK (2016). Discovery of in vivo targets of transcriptional activators via in vivo covalent chemical capture.  J. Am. Chem. Soc. 2016, 138, 12629-35. PubMed link

Bruno PA, Morriss-Andrews A, Henderson AR, Brooks III CL, Mapp AK (2016).  A synthetic loop replacement peptide blocks canonical NF-κB signaling.  Angew. Chemie Int. Ed.  55 (48), pp. 14997-15001.  PubMed link