Mapp Lab

Our Research

The Mapp research group uses the tools of synthetic organic chemistry, biochemistry, and molecular biology to better understand how genes are regulated.

Projects in the group range from the development of new synthetic methods for preparing complex, optically active structures to manipulating genes in Saccharomyces cerevisiae (yeast) in order to identify key protein-protein interactions in gene activation.

Our group is multidisciplinary with students from the Medicinal Chemistry Program, Program in Chemical Biology, and the Department of Chemistry.

About Anna Mapp

Anna Mapp focuses on developing a molecular-level picture of inducible gene expression in eukaryotes using organic molecules as mechanistic probes. She is also the Director of the Program in Chemical Biology.

Mapp Lab News

Anna Mapp and her lab joined the LSI in May 2013. Mapp is also director of the Program in Chemical Biology, which is now housed in the LSI.

New:Photos from the Program in Chemical Biology10th Anniversary

Recent publications

Law SM, Gagnon JK, Mapp AK, Brooks CL (2014). Prepaying the entropic cost for allosteric regulation in KIX. 3rd. Proc Natl Acad Sci U S A. 111(33), pp. 12067-72. PubMed link

Wang N, Lodge JM, Fierke CA, Mapp AK. (2014). Dissecting allosteric effects of activator-coactivator complexes using a covalent small molecule ligand. Proc Natl Acad Sci U S A. 19;111(33)pp. 12061 - 12066. PubMed link

Mapp AK, Pricer R, Sturlis S. (2015). Targeting transcription is no longer a quixotic quest. Nat Chem Biol., 11(12), pp. 891 - 894. PubMed link