Wu Publications

Representative Research Articles (selected from 25 published/in press):

Yu H, Emont M, Jun H and Wu J. (2018) Isolation and differentiation of murine primary brown/beige preadipocytes. Methods Mol Biol. In press. 

Jiang J, Emont MP, Jun H, Qiao X, Liao J, Kim DI and Wu J. (2017) Cinnamaldehyde induces fat cell-autonomous thermogenesis and metabolic reprogramming. Metabolism 77:58-64. PMID: 29046261.

Li S, Mi L, Yu L, Yu Q, Liu T, Wang GX, Zhao XY, Wu J and Lin JD. (2017) Zbtb7b engages the long noncoding RNA Blnc1 to drive brown and beige fat development and thermogenesis.  Proc Natl Acad Sci U S A. 114(34): E7111-E7120. PMID: 28784777. 

Liu L, Zheng LD, Donnelly SR, Emont MP, Wu J, Cheng Z. (2017) Isolation of mouse stromal vascular cells for monolayer culture. Methods Mol Biol. 1566:9-16. PMID:28244036. 

Emont MP, Yu H, Jun H, Hong X, Maganti N, Stegemann JP and Wu J. (2015) Using a 3D culture system to differentiate visceral adipocytes in vitro. Endocrinology. 156(12):4761-8. PMID:26425808. PubMed link; News coverage

van der Lans AA, Hoeks J, Brans B, Vijgen GH, Visser MG, Vosselman MJ, Hansen J, Jorgensen JA, Wu J, Mottaghy F, Schrauwen P and van Marken Lichtenbelt WD. (2013) Cold acclimation recruits human brown fat and increases nonshivering thermogenesis. J Clin Invest. 123(8):3395-403. PMID: 23867626. PubMed link

Ye L, Wu J, Cohen P, Kazak L, Khandekar MJ, Jedrychowski MP, Zeng X, Gygi SP and Spiegelman BM. (2013). Fat cells directly sense temperature to activate thermogenesis. Proc Natl Acad Sci U S A. 110(30): 12480-5. PMID: 23818608. PubMed link

Rajakumari S*, Wu J*, Ishibashi J, Hee-Woong L, Giang AH, Won KJ, Reed RR and Seale P. (2013) EBF2 determines and maintains brown adipocyte identity. Cell Metab. 17(4):562-74. PMID: 23499423.  *These authors contributed equally to the work. PubMed link

Ye L, Kleiner S, Wu J, Sah R, Gupta RK, Banks AS, Cohen P, Khandekar, MJ, Boström P, Mepani R, Laznik D, Kamenecka TM, Song X, Liedtke W, Mootha VK, Puigserver, P, Griffin PR, Clapham D and Spiegelman BM. (2012) TRPV4 is a regulator of adipose oxidative metabolism, inflammation and energy homeostasis.  Cell. 151(1):96-110. PMID: 23021218. PubMed link

Wu J, Boström P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, Huang K, Tu H, van Marken Lichtenbelt WD, Hoeks J, Enerbäck S, Schrauwen P and Spiegelman BM. (2012) Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human.  Cell. 150(2):366-76. PMID: 22796012. PubMed link

Wu J, Ruas JL, Estall JL, Rasbach KA, Choi JH, Ye L, Boström P, Tyra HM, Crawford RW, Campbell KP, Rutkowski DT, Kaufman RJ, Spiegelman BM. (2011) The unfolded protein response mediates adaptation to exercise in skeletal muscle through a protein complex of PGC-1alpha/ATF6alpha.  Cell Metab. 13(2):160-9. PMCID: PMC3057411. PubMed link

Boström P, Mann N, Wu J, Quintero PA, Plovie ER, Panakova D, Gupta R, Xiao C, MacRae CA, Rosenzweig A, Spiegelman B. (2010) C/EBPbeta controls exercise-induced cardiac growth and protects against pathological cardiac remodeling.  Cell. 143(7):1072-83. PMCID: PMC3035164. PubMed link

Rutkowski DT*, Wu J*, Back SH, Callaghan MU, Ferris SP, Iqbal J, Clark R, Miao H, Hassler JR, Fornek J, Katze MG, Hussain MM, Song B, Swathirajan J, Wang J, Yau GD, Kaufman RJ. (2008) UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators.  Dev Cell. 15(6):829-840. PMCID: PMC2923556. *These authors contributed equally to the work. PubMed link

Sakaki K, Wu J, Kaufman RJ. (2008) Protein kinase C-theta is required for autophagy in response to stress in the endoplasmic reticulum.  J Biol Chem. 283(22):15370-15380. PMCID: PMC2397484. PubMed link

Wu J*, Rutkowski DT*, Dubois M, Swathirajan J, Saunders T, Wang J, Song B, Yau GD, Kaufman RJ. (2007) ATF6alpha optimizes long-term endoplasmic reticulum function to protect cells from chronic stress. Dev Cell. 13(3):351-364. *These authors contributed equally to the work. PubMed link

Zhang K, Shen X, Wu J, Sakaki K, Saunders T, Rutkowski DT, Back SH, Kaufman RJ. (2006) Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response. Cell. 124(3):587-599. PubMed link

Inoki K, Li Y, Zhou T, Wu J, Guan KL. (2002) TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol. 4(9):648-657. PubMed link

Representative Reviews and Commentaries (selected from 7 published/in press):

Wu J. (2016) Molecular regulation and therapeutic potential of thermogenic fat cells. Front. Endocrinol. (Lausanne). 7:26. doi: 10.3389/fendo.2016.00026. PMID: 27065947. PubMed link

Wu J#, Jun H and McDermott JR. (2015) Formation and activation of thermogenic fat. Trends Genet. 31(5):232-238. PMID: 25851693. # Correspondence author. PubMed link

Emont M, Yu H and Wu J. (2015) Transcriptional control and hormonal response of thermogenic fat. J Endocrinol. 225(2): R35-R47. PMID: 25804606 PubMed link

Jun H and Wu J. (2015) Hot cells, raise your hands. Clin Chem. 61:459-461 PMID:25451867. PubMed link

Wu J, Cohen P and Spiegelman BM. (2013) Adaptive thermogenesis in adipocytes: Is beige the new brown?  Genes Dev. 27(3):234-50. PMID: 23388824. PubMed link