Publications
Recent Articles | Articles (1995-2004) | Articles (1984-1994)
Recent Articles
Zolov S.N., Bridges, D., Zhang Y., Lee, W-W., Riehle, E., Verma R., Lenk, G.M., Converso-Baran, K., Weide, T., Albin R.L., Saltiel, A.R., Meisler, M.H., Russell, M.W. and Weisman L.S. (2012) In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P. PNAS (Epub ahead of print) PubMed Link
Zhang, Y., McCartney, A.J., Zolov, S.N., Ferguson, C., Meisler, M., Sutton, M.A. and Weisman, L.S. (2012) Modulation of Synaptic Function by VAC14, a Protein that Regulates the Phosphoinositide PI(3,5)P2. EMBO J. 31:3442-56. PMCID: PMC3419932. PubMed Link
Bridges, D., Ma, J.T., Parks, S., Inoki, K., Weisman, L.S. and Saltiel, A.R. (2012) Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1. Mol Bio Cell, 15:2955-62. PMCID: PMC3408421. PubMed Link
Eves P.T., Jin Y., Brunner M.J., and Weisman L.S. (2012) Overlap of cargo binding sites on myosin V coordinates the inheritance of diverse cargoes. J. Cell Biol. 198:69-85. PMCID: PMC3392941. PubMed Link
Bridges, D., Fisher, K., Zolov, S.N., Xiong, T., Inoki, K., Weisman, L.S., and Saltiel, A.R. (2012) Rab5 Proteins Regulate the Activation and Localization of Target of Rapamycin Complex 1. J. Biol Chem. 287:20913-21. PMCID: PMC3375515. PubMed Link
Vaccari, I., Dina, G., Tronchère, H., Kaufman, E. Chicanne, G., Cerr, F., Wrabetz, L., Payrastre, B., Quattrini, A., Weisman, L.S., Meisler, M. and Bolino, A. (2011) Human Genetic Interaction between MTMR2 and FIG4 Phospholipid phosphatases Involved in Charcot-Marie-Tooth Neuropathies. PLoS Genet. 10:e1002319. PMCID: PMC3197679. PubMed Link
Sultana, A., Dregger, C., Jin, Y., Franklin, E, Weisman, L.S. and Khan, A.R. (2011) The Activation Cycle of Ypt32 Reveals Structural Determinants of Effector Recruitment by Yeast Rab GTPases. FEBS Lett. 585:3520-7. PMCID: PMC3222890. PubMed Link
Jin, Y., Sultana, A., Gandhi, P., Franklin, E. Hamamoto, S., Khan A.R., Munson, M., Schekman, R. and Weisman L.S. (2011) Myosin V transports secretory vesicles via a Rab GTPase cascade and interaction with the exocyst complex. Developmental Cell 21:1156-70. PMCID: PMC3241923. PubMed Link
Lenk, G.M., Ferguson, C.J., Chow, C.Y., Jin, N, Jones, J.M., Grant, A.E., Zolov, S.N., Winters, J.J., Giger, R.J., Dowling, J.J., Weisman, L.S. and Meisler, M.H. (2011) Pathogenic Mechanism of the FIG4 Mutation Responsible for Charcot-Marie-Tooth Disease CMT4J. PLoS Genet. 7:e1002104: PMCID: PMC3107197. PubMed Link
Birkeland, S.R., Jin, N., Ozdemir, A.C., Lyons, R.H. Jr., Weisman, L.S. and Wilson, T.E. (2010) Discovery of mutations in Saccharomyces cerevisiae by pooled linkage analysis and whole-genome sequencing. Genetics 186:1127-37 PMCID: PMC2998298. PubMed Link
Dong, X., Shen, D., Wang, X. Dawson, T., Li X., Zhang, Q. Cheng, X., Zhang, Y., Weisman, L.S., Delling, M. and Xu, H. (2010) PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosome. Nat. Commun., 1:38. PMCID: PMC2928581. PubMed Link
Fagarasanu, A., Mast, F.D., Knoblach., B., Jin, Y., Brunner, M.J., Logan, M.R., Glover, M., Eitzen, G.A., Aitchison, J.D., Weisman, L.S., and Rachubinski, R.A. (2009) Myosin-driven peroxisome partitioning in S. cerevisiae. J. Cell Biol., 186:541-54. PMCID: PMC2733749. PubMed Link
Jin, Y., Eves, P.T., Tang, F. and Weisman, L.S. (2009) PTC1 is required for vacuole inheritance and promotes the association of the myosin-V vacuole-specific receptor complex. Mol. Biol. Cell, 20:1312-1323. PMCID: PMC2649272. PubMed Link
Chow, C.Y., Landers, J.E., Bergren, S.K., Sapp, P.C., Grant, A.E., Jones, J.M., Everett, L., Lenk, G.M., McKenna-Yasek, D.M., Weisman, L.S., Figlewicz, D., Brown, R.H., and Meisler, M.H. (2009) Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS. Am J Hum Genet., 84:85-8. PMCID: PMC2668033. PubMed Link
Jin N., Chow, C.Y., Liu, L., Zolov, S.N., Bronson, R., Ward-Bailey, P.F., Davisson, M., Petersen, J.L., Zhang, Y., Park, S., Duex, J., Goldowitz, D., Meisler, M.H., and Weisman, L.S. (2008) VAC14 nucleates a protein complex that is essential for the acute interconversion of PI3P and PI(3,5)P2 in yeast and mouse. EMBO J., 27:3221-34. PMCID: PMC2600653. PubMed Link
Lipatova, Z., Tokarev A., Jin, Y., Mulholland, J., Weisman, L.S. and Segev, N. (2008) Direct interaction between a myosin V motor and the Rab GTPases Ypt31/32 is required for polarized secretion. Mol. Biol. Cell, 19:4177-87. PMCID: PMC2555963. PubMed Link
Peng, Y. and Weisman L.S. (2008) The cyclin-dependent kinase, Cdk1, directly regulates vacuole inheritance. Developmental Cell, 15:478-485. PMCID: PMC2727752. PubMed Link
Lodhi, I., Bridges, D., Chiang, S., Zhang, Y., Cheng, A., Geletka, L.M., Weisman, L.S. and Saltiel, A.R. (2008) Insulin stimulates phosphatidylinositol 3-phosphate production via the activation of Rab5. Mol Biol Cell, 19:2718-2728. PMCID: PMC2441665. PubMed Link
Valiathan, R. and Weisman, L.S. (2008) Pushing for answers: is myosin V directly involved in moving mitochondria? J. Cell Biol., 181:5-18. PMCID: PMC2287276. PubMed Link
Zhang, Y, Zolov, S.N., Chow, C.Y., Slutsky, S.G., Richardson, S.C., Piper, R.C., Yang, B., Nau, J.J., Westrick, R.J., Morrison, S.J., Meisler, M.H. and Weisman, L.S. (2007) Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci USA, 104:17518-17523. PMCID: PMC2077288. PubMed Link
Chow, C.Y., Zhang, Y., Dowling, J., Jin, N., Adamska, M., Shiga, K., Szigeta, L., Shy, M., Li, J., Zhang, X., Lupski, J.R., Weisman, L.S. and Meisler, M.H. (2007) Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature 448:68-72. PMCID: PMC2271033. PubMed Link
Peng, Y., Tang, F. and Weisman L.S. (2006) Palmitoylation plays a role in targeting Vac8p to specific membrane microdomains. Traffic 7:1378-87. PMID: 16978392. PubMed Link
Tang, F. Peng, Y., Nau, J.J. and Weisman L.S. (2006) Vac8p, an armadillo repeat protein, coordinates vacuole inheritance with multiple vacuolar processes. Traffic, 7:1368-77. PMID: 16824055. PubMed Link
Deux, J.E., Nau, J.J. Kauffman, E.J. and Weisman, L.S. (2006) Phosphoinositide 5-phosphatase Fig 4p is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3,5-bisphosphate levels. Eukaryotic Cell 5:723-731. PMCID: PMC1459661. PubMed Link
Deux, J.E., Tang, F. and Weisman, L.S. (2006) The Vac14p/Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover. J. Cell Biol., 172:693-704. PMCID: PMC2063702. PubMed Link
Pashkova, N., Jin, Y., Ramaswamy, S. and Weisman, L.S. (2006) Structural basis for myosin V discrimination between distinct cargoes. EMBO J., 25:693-700. PMCID: PMC1383548. PubMed Link
Pashkova, N., Catlett, N.L., Novak, J.L. and Weisman, L.S. (2005) A point mutation in the cargo-binding domain of myosin V affects its interaction with multiple cargoes. Eukaryotic Cell, 4:787-798. PMCID: PMC1705953. PubMed Link
Pashkova, N., Catlett, N.L., Novak, J.L., Wu, G., Lu, R., Cohen, R.E. and Weisman, L.S. (2005) Myosin V attachment to cargo requires the tight association of two functional sub-domains. J. Cell Biol., 168:359-364. PMCID: PMC2171732. PubMed Link
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Articles (1995-2004)
Wang, C.W., Stromhaug, P.E., Kauffman, E.J., Weisman, L.S. and Klionsky, D.J. (2003) Yeast homotypic vacuole fusion requires the Ccz1-Mon1 complex during the tethering/docking stage. J. Cell Biol., 163:973-85. PMCID: PMC1705953. PubMed Link
Ishikawa, K., Catlett, N.L., Novak, J.L., Tang, F., Nau, J.J. and Weisman, L.S. (2003) Identification of an organelle-specific myosin-V receptor. J. Cell Biol., 160:887-897. PMCID: PMC2173761. PubMed Link
Tang, F., Kauffman, E. J., Novak, J.L., Nau, J.J., Catlett, N.L. and Weisman, L.S. (2003) Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole. Nature, 422:87-92. PMID: 12594460. PubMed Link
Gary, J.D., Sato, T.K., Stefan, C.J., Bonangelino, C.J., Weisman, L.S. and Emr, S.D. (2002) Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Mol. Biol. Cell, 13:1238-1251. PMCID: PMC102265. PubMed Link
Bonangelino, C.J., Nau, J.J., Duex, J.E., Brinkman, M.R. Wurmser, A.E., Gary, J.D., Emr, S.D. and Weisman, L.S. (2002) Osmotic stress induced increase of phosphatidylinositol 3,5 bisphosphate requires Vac14p an activator of the lipid kinase, Fab1p. J. Cell Biol., 156:1015-1028. PMCID: PMC2173454. PubMed Link
Wang, Y.X., Kauffman, E.J., Duex, J.E. and Weisman, L.S. (2001) Fusion of docked membranes requires the armadillo repeat protein Vac8p. J. Biol. Chem., 276:35133-35140. PMID: 11441010. PubMed Link
Scott, S.V., Nice, D.C. III, Nau, J.J., Weisman, L.S., Kamada, Y., Keizer-Gunnink, I., Funakoshi, T., Veenhuis, M., Ohsumi,Y. and Klionsky, D.J. (2000) Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. J. Biol. Chem., 275:25840-25849. PMID: 10837477. PubMed Link
Catlett, N.L., Duex, J.E., Tang, F. and Weisman, L.S. (2000) Two distinct regions in a yeast myosin V tail domain are required for the movement of different cargoes. J. Cell Biol., 150:513-525. PMCID: PMC2175197. PubMed Link
Catlett, N.L. and Weisman, L.S. (1998) The terminal tail-region of a yeast myosin-v mediates its attachment to vacuole membranes and sites of polarized growth. Proc. Natl. Acad. Sci. USA, 95:14799-14804. PMCID: PMC24529. PubMed Link
Gary, J.D, Wurmser, A.E., Bonangelino, C..J., Weisman, L.S. and Emr, S.D. (1998) FAB1 encodes a PtdIns(3)P 5-kinase essential for the maintenance of vacuole size and membrane homeostasis. J. Cell Biol., 143:65-79. PMCID: PMC2132800. PubMed Link
Bryant, N.J., Piper, R.C., Weisman, L.S. and Stevens, T.H. (1998) Retrograde traffic out of the yeast vacuole to the TGN occurs via the prevacuolar/endosomal compartment. J. Cell Biol., 142:651-663. PMCID: PMC2148167. PubMed Link
Bonangelino, C., Catlett, N.L. and Weisman, L.S. (1997) Vac7p, a novel vacuolar protein is required for normal vacuole inheritance and morphology. Molec. Cell Biol., 17:6847-6858. PMCID: PMC232541. PubMed Link
Hill, K.L., Catlett, N.L. and Weisman, L.S. (1996) Actin and myosin function in directed vacuole movement during cell division in Saccharomyces cerevisiae. J. Cell Biol., 135:1535-1550. PMCID: PMC2133941. PubMed Link
Wang, Y.X., Catlett, N.L. and Weisman, L.S. (1998) Vac8p, a vacuolar protein with armadillo repeats, functions in both vacuole inheritance and protein targeting from the cytoplasm to the vacuole. J. Cell Biol., 140:1063-1074. PMCID: PMC275988. PubMed Link
Wang, Y.X., Zhao, H., Harding, T., Gomes de Mesquita, D., Woldringh, C.L., Klionsky, D., Munn, A. and Weisman, L.S. (1996) Multiple classes of yeast mutants are defective in vacuole partitioning yet target vacuole proteins correctly. Molec. Biol. Cell, 7:1375-1389. PMCID: PMC275988. PubMed Link
Nicolson, T.A., Weisman, L.S., Payne, G.S. and Wickner, W. (1995) A truncated form of the PHO80 cyclin redirects the PHO85 kinase to disrupt vacuole inheritance in S. cerevisiae. J. Cell Biol., 130:835-845. PMCID: PMC2199970. PubMed Link
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Articles (1984-1994)
Weisman, L.S. and Wickner, W. (1992) Molecular characterization of VAC1, a gene required for vacuole inheritance and vacuole protein sorting. J. Biol. Chem., 267:618-623. PMID: 1730622. PubMed Link
Weisman, L.S., Emr, S.D. and Wickner, W. (1990) Mutants of Saccharomyces cerevisiae that block intervacuole vesicular traffic and vacuole division and segregation. Proc. Natl. Acad. of Sci. USA, 87:1076-1080. PMCID: PMC53413. PubMed Link
Bryant N.J., Piper, R.C., Weisman, L.S. and Stevens, T.H. (1998) Retrograde traffic out of the yeast vacuole to the TGN occurs via the prevacuolar/endosomal compartment. J Cell Biol., 142:651-63. PMCID: PMC2148167. JBC Link
Weisman, L.S. and Wickner, W. (1988) Intervacuole exchange in the yeast zygote: a new pathway in organelle communication. Science, 241:589-591. PMID: 3041591. PubMed Link
Weisman, L.S. and Ballou, C.E. (1988) Methanol formation in Mycobacterium smegmatis. J. Bacteriol., 170:1393-1395. PMCID: PMC210923. PubMed Link
Weisman, L.S., Bacallao, R. and Wickner, W. (1987) Multiple methods of visualizing the yeast vacuole permit an evaluation of its morphology and inheritance during the cell cycle. J. Cell Biol., 105:1539-1547. PMCID: PMC2114659. PubMed Link
Weisman, L.S., Krummel, B.M. and Wilson, A.C. (1986) Evolutionary shift in the site of cleavage of Prelysozyme. J. Biol. Chem., 261:2309-2313. PMID: 3511061. PubMed Link
Weisman, L.S. and Ballou, C.E. (1984) Biosynthesis of the mycobacterial methylmannose polysaccharide - identification of a 3-0-methyltransferase. J. Biol. Chem., 259:3464-3469. JBC Link
Weisman, L.S. and Ballou, C.E. (1984) Biosynthesis of the mycobacterial methylmannose polysaccharide - identification of an a1→4 mannosyltransferase. J. Biol. Chem., 259:3457-3463. PubMed Link
