Publications
For a list updated daily, please see Tesmer JJ on Pubmed.
Recent Articles | Articles (2005-2009) | Articles (1990-2004) | Review Articles
Editorial Material | Notes
Recent Articles
Nance MR, Kreutz B, Tesmer VM, Sterne-Marr R, Kozasa T, Tesmer JJG (2013). Structural and functional analysis of the regulator of G protein signaling 2 (RGS2)-Gαq complex. Structure, in press.
Lyon AM, Dutta S, Boguth CA, Skiniotis G, Tesmer JJG (2013). Structure of full-length phospholipase C β3 in complex with Gαq reveals functional interfaces of its C-terminal coiled-coil domain. Nature Struct. Mol. Biol., in press.
Thal DM, Homan KT, Chen J, Wu E, Hinkle PM, Huang ZM, Chuprun JK, Song J, Gao E, Cheung JC, Sklar L, Koch WJ, and Tesmer JJG (2012). Paroxetine is a direct inhibitor of G protein-coupled receptor kinase 2 and increases myocardial contractility. ACS Chem. Biol., 7: 1830-1839. PMCID: 3500392. PubMed Link
Tesmer VM, Lennarz S, Mayer G, Tesmer JJG (2012). Molecular mechanism for inhibition of G protein-coupled receptor kinase 2 by a selective RNA aptamer. Structure, 20: 1300-1309. PMCID: 3418449. PubMed Link
Tesmer JJG, Nance MR, Singh P, Lee H (2012). Structure of a monomeric variant of rhodopsin kinase at 2.5 Å resolution. Acta Cryst., F86: 622-625. PMCID: 3370896. PubMed Link
Orban T, Huang C-c, Homan KT, Jastrzebska B, Tesmer JJG and Palczewski P (2012). Substrate-induced changes in dynamics of G protein-coupled receptor kinase 1 (rhodopsin kinase). Biochemistry, 51, 3404-3411. PMCID: 3422436. PubMed Link
Edwards BS, Zhu JS, Chen J, Carter MB, Thal DM, Tesmer JJG, Graves SW, Sklar LA (2012). Cluster cytometry for high capacity bioanalysis. Cyotmetry A, 81: 419-29. PMCID: 3331957. Pubmed Link
Narasimhan D, Collins GT, Nance MR, Nichols J, Edwald E, Chan J, Ko M-C, Woods JH, Tesmer JJ, and Sunahara RK (2011): Subunit stabilization and PEGylation of cocaine esterase improves in vivo residence time. Mol. Pharm. 80:1056-65. Pubmed Link
Boughton AP, Yang P, Tesmer VM, Ding B, Tesmer JJ, Chen Z (2011). Heterotrimeric G protein β1γ2 subunits change orientation upon complex formation with G protein-coupled receptor kinase 2 (GRK2) on a model membrane. Proc. Natl. Acad. Sci. U.S.A. 108: E667-73. Pubmed Link
Aittaleb M, Nishimura A, Linder ME, Tesmer JJ (2011). Plasma membrane association of p63RhoGEF is mediated by palmitoylation and is required for basal activity in cells. J. Biol. Chem., 286:34448-56. Pubmed Link
Lyon AM, Tesmer VM, Dhamsania VD, Thal DM, Gutierrez J, Chowdhury S, Suddala KC, Northup JK, Tesmer JJ (2011). An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation. Nat Struct. Mol. Biol., 18:999-1005. Pubmed Link
Thal DM, Yeow RY, Schoenau C, Huber J, Tesmer JJ (2011). Molecular mechanism of selectivity among G protein-coupled receptor kinase 2 inhibitors. Mol Pharm., 80:294-303. Pubmed Link
Huang CC, Orban T, Jastrzebska B, Palczewski K, Tesmer JJ. (2011). Activation of G protein-coupled receptor kinase 1 involves interactions between its N-terminal region and its kinase domain. Biochemistry, 50:1940-9. Pubmed Link
Bayburt TH, Vishnivetskiy SA, McLean MA, Morizumi T, Huang CC, Tesmer JJ, Ernst OP, Sligar SG, Gurevich VV (2010). Monomeric rhodopsin is sufficient for normal rhodopsin kinase (GRK1) phosphorylation and arrestin-1 binding. J Biol Chem., 286:1420-8.Pubmed Link
Boguth CA, Singh P, Huang CC, Tesmer JJ (2010). Molecular basis for activation of G protein-coupled receptor kinases. EMBO J., 29:3249-59. Article Link
Narasimhan D, Nance MR, Gao D, Ko MC, Macdonald J, Tamburi P, Yoon D, Landry DM, Woods JH, Zhan CG, Tesmer JJ, Sunahara RK (2010). Structural analysis of thermostabilizing mutations of cocaine esterase. Protein Eng Des Sel. 23:537-47. Article Link
Shankaranarayanan A, Boguth CA, Lutz S, Vettel C, Uhlemann F, Aittaleb M, Wieland T, Tesmer JJ (2010). Gαq allosterically activates and relieves autoinhibition of p63RhoGEF. Cell Signal., 22:1114-23. Pubmed Link
Tesmer JJ, Tesmer VM, Lodowski DT, Steinhagen H, Huber J (2010). Structure of human G protein-coupled receptor kinase 2 in complex with the kinase inhibitor balanol. J Med Chem. 53: 1867-1870. Article Link
Brim R.L., Nance M.R., Youngstrom D.W., Narasimhan D., Zhan C.G., Tesmer J.J., Sunahara R.K., Woods J.H. (2010). A thermally stable form of bacterial cocaine esterase: a potential therapeutic agent for treatment of cocaine abuse. Mol Pharmacol., 77(4):593-600. Pubmed Link
Talbot J.N., Roman D.L., Clark M.J., Roof R.A., Tesmer J.J., Neubig R.R., Traynor J.R. (2010). Differential modulation of mu-opioid receptor signaling to adenylyl cyclase by regulators of G protein signaling proteins 4 or 8 and 7 in permeabilised C6 cells is Gα subtype dependent. J Neurochem., 112:1026-34. Pubmed Link
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Articles (2005-2009)
Aittaleb M, Gao G, Evelyn CR, Neubig RR, Tesmer JJ (2009). A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells. Cell Signal. 21: 1569-78. Pubmed Link
Huang CC, Yoshino-Koh K, Tesmer JJ (2009). A surface of the kinase domain critical for the allosteric activation of G protein-coupled receptor kinases. J Biol Chem. 284:17206-15. Pubmed Link
Sterne-Marr R., Leahey P.A., Bresee J.E., Dickson H.M., Ho W., Ragusa M.J., Donnelly R.M., Amie S.M., Krywy J.A., Brookins-Danz E.D., Orakwue S.C., Carr M.J., Yoshino-Koh K., Li Q., Tesmer JJG. (2009). GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail. Biochemistry, 48, 4285-93. Pubmed Link
Shankaranarayanan A., Thal D.M., Tesmer V.M., Roman D.L., Neubig R.R., Kozasa T., Tesmer J.J.G. (2008). Assembly of high order G alpha q-effector complexes with RGS proteins. J Biol Chem., 285, 34923-34. Pubmed Link
Singh P., Wang B., Maeda T., Palczewski K., Tesmer J.J.G. (2008). Structures of rhodopsin kinase in different ligand states reveal key elements involved in G protein-coupled receptor kinase activation. JBC, 283, 14053-62. Pubmed Link
Lutz S., Shankaranarayanan A., Coco C., Ridilla M., Nance M.R., Vettel C., Baltus D., Evelyn C.R., Neubig R.R., Wieland T., Tesmer J.J.G. (2007). Structure of Gαq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. Science, 318, 1923-7. Abstract | Full Text
Williams S.L., Lutz S., Charlie N.K., Vettel C., Ailion M., Coco C., Tesmer J.J.G., Jorgensen E.M., Wieland T., Miller K.G. (2007). Trio's Rho-specific GEF domain is the missing Gαq effector in C. elegans. Genes Dev., 21, 2731-46. Pubmed Link
Chen X., Boughton A.P., Tesmer J.J.G., Chen Z. (2007). In situ investigation of heterptrimeric G proteins βγ subunit binding and orientation on membrane bilayers. J Am chem Soc., 129, 12658-9. Pubmed Link
Gu S., He J., Ho W.T., Ramineni S., Thal D.M., Natesh R., Tesmer J.J.G., Hepler J.R., Heximer S.P. (2007). Unique hydrophobic extension of the RGS2 amphipathic helix domain imparts increased plasma membrane binding and function relative to other RGS R4/B subfamily members. J Biol Chem, 282, 33064-33075. Pubmed Link
Li, Q., Nance, M.R., Kulikauskas, R., Nyberg, K., Fehon, R., Karplus, P.A., Bretscher, A., & Tesmer, J.J.G. (2007). Self-masking in an Intact ERM-merlin Protein: An Active Role for the Central α-Helical Domain. Journal of Molecular Biology, 365, 1446-1459. Pubmed Link
Lodowski, D. T., Tesmer, V. M., Benovic, J. L., & Tesmer, J. J. G. (2006). The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs. J. Biol. Chem., 281: 16785-16793. PubMed Link
Kreutz, B., Yau, D. M., Nance, M., Tanabe, S., Tesmer, J. J. G., & Kozasa, T. (2006). A new approach to producing functional Gα subunits yields the activated and deactivated structures of Gα12/13 proteins. Biochemistry, 45, 167-174. PubMed Link
Lodowski, D. T., Barnhill, J. F., Pyskadlo, R. M., Ghirlando, R., Sterne-Marr, R., & Tesmer, J. J. G. (2005). The role of Gβγ and domain interfaces in the activation of G protein-coupled receptor kinase 2. Biochemistry, 44, 6958-6970. PubMed Link
Tesmer, V. M., Kawano, T., Shankaranarayanan, A., Kozasa, T., & Tesmer, J. J. G. (2005). Snapshot of activated G proteins at the membrane: The Gαq-GRK2-Gβγ complex. Science, 310: 1686-1690. Abstract | Full Text
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Articles (1990-2004)
Kristelly, R., Gao, G., & Tesmer, J. J. G. (2004). Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. Journal of Biological Chemistry, 279, 47352-47362. PubMed Link
Day, P. W., Tesmer, J. J. G., Sterne-Marr, R., Freeman, L. C., Benovic, J. L., & Wedegaertner, P. B. (2004). Characterization of the GRK2 binding site of Gα(q). Journal of Biological Chemistry, 279, 53643-53652. PubMed Link
Lodowski, D. T., Barnhill, J. F., Pitcher, J. A., Capel, W. D., Lefkowitz, R. J., & Tesmer, J. J. G. (2003). Purification, crystallization and preliminary X-ray diffraction studies of a complex between G protein-coupled receptor kinase 2 and Gβ(1)γ(2). Acta Crystallographica Section D – Biological Crystallography, 59, 936-939.
Kristelly, R., Earnest, B. T., Krishnamoorthy, L., & Tesmer, J. J. G. (2003). Preliminary structure analysis of the DH/PH domains of leukemia-associated RhoGEF. Acta Crystallographica Section D - Biological Crystallography, 59, 1859-1862. PubMed Link
Sterne-Marr, R., Tesmer, J. J. G., Day, P. W., Stracquatanio, R. P., Cilente, J. A. E., O'Connor, K. E., Pronin, A. N., Benovic, J. L., & Wedegaertner, P. B. (2003). G protein-coupled receptor kinase 2/Gα(q/11) interaction - A novel surface on a regulator of G protein signaling homology domain for binding Gα subunits. Journal of Biological Chemistry, 278, 6050-6058.
Lodowski, D. T., Pitcher, J. A., Capel, W. D., Lefkowitz, R. J., & Tesmer, J. J. G. (2003). Keeping G proteins at bay: A complex between G protein-coupled receptor kinase 2 and Gβγ. Science, 300,1256-1262. Abstract | Full Text
Tesmer, J. J. G., Dessauer, C. W., Sunahara, R. K., Murray, L. D., Johnson, R. A., Gilman, A. G., & Sprang, S. R. (2000). Molecular basis for P-site inhibition of adenylyl cyclase. Biochemistry, 39, 14464-14471. PubMed Link
Pitcher, J. A., Tesmer, J. J. G., Freeman, J. L. R., Capel, W. D., Stone, W. C., & Lefkowitz, R. J. (1999). Feedback inhibition of G protein-coupled receptor kinase 2 (GRK2) activity by extracellular signal-regulated kinases. Journal of Biological Chemistry, 274, 34531-34534. PubMed Link
Tesmer, J. J. G., Sunahara, R. K., Johnson, R. A., Gosselin, G., Gilman, A. G., & Sprang, S. R. (1999). Two-metal-ion catalysis in adenylyl cyclase. Science, 285, 756-760. PubMed Link
Tesmer, J. J. G., & Sprang, S. R. (1998). The structure, catalytic mechanism and regulation of adenylyl cyclase. Current Opinion in Structural Biology, 8, 713-719. PubMed Link
Sunahara, R. K., Beuve, A., Tesmer, J. J. G., Sprang, S. R., Garbers, D. L., & Gilman, A. G. (1998). Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases. Journal of Biological Chemistry, 273, 16332-16338. PubMed Link
Dessauer, C. W., Tesmer, J. J. G., Sprang, S. R., & Gilman, A. G. (1998). Identification of a G(iα) binding site on type V adenylyl cyclase. Journal of Biological Chemistry, 273, 25831-25839. PubMed Link
Tesmer, J. J. G., Berman, D. M., Gilman, A. G., & Sprang, S. R. (1997). Structure of RGS4 bound to AlF4--activated G(iα 1): Stabilization of the transition state for GTP hydrolysis. Cell, 89, 251-261. PubMed Link
Tesmer, J. J. G., Sunahara, R. K., Gilman, A. G., & Sprang, S. R. (1997). Crystal structure of the catalytic domains of adenylyl cyclase in a complex with G(sα).GTPγ S. Science, 278, 1907-1916. PubMed Link
Sunahara, R. K., Tesmer, J. J. G., Gilman, A. G., & Sprang, S. R. (1997). Crystal structure of the adenylyl cyclase activator G(Sα). Science, 278, 1943-1947. PubMed Link
Tesmer, J. G., Klem, T. J., Deras, M. L., Davisson, V. J., & Smith, J. L. (1996). The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families. Nature Structural Biology, 3, 74-86. PubMed Link
Tesmer, J. J. G., Stemmler, T. L., Pennerhahn, J. E., Davisson, V. J., & Smith, J. L. (1994). Preliminary X-ray analysis of Escherichia coli GMP synthetase - determination of anomalous scattering factors for a cysteinyl mercury derivative. Proteins - Structure, Function and Genetics, 18, 394-403. PubMed Link
Vermersch, P. S., Lemon, D. D., Tesmer, J. J. G., & Quiocho, F. A. (1991). Sugar-binding and crystallographic studies of an arabinose-binding protein mutant (MET108LEU) that exhibits enhanced affinity and altered specificity. Biochemistry, 30, 6861-6866. PubMed Link
Vermersch, P. S., Tesmer, J. J. G., Lemon, D. D., & Quiocho, F. A. (1990). A pro to gly mutation in the hinge of the arabinose-binding protein enhances binding and alters specificity - sugar-binding and crystallographic studies. Journal of Biological Chemistry, 265, 16592-16603. PubMed Link
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Review Articles
Gurevich EV, Tesmer JJ, Mushegian A, Gurevich VV (2011): G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol. Ther. 133:40-69. Pubmed Link
Tesmer JJ (2011): Activation of G Protein-Coupled Receptor (GPCR) Kinases by GPCRs. In “RSC Drug Discovery Series 8; G protein-coupled receptors: from structure to function”. Eds. Jesús Giraldo and Jean-Philippe Pin, The Royal Society of Chemistry, pp. 297-315.
Huang CC, Tesmer JJ (2011). Recognition in the face of diversity: interactions of heterotrimeric G proteins and G protein-coupled receptor (GPCR) kinases with activated GPCRs. J Biol Chem. 286:7715-21. Pubmed Link
Tesmer JJ (2010). The quest to understand heterotrimeric G protein signaling. Nat Struct Mol Biol., 17:650-2. Article Link
Aittaleb M, Boguth CA, Tesmer JJ (2009). Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors. Mol Pharmacol 77:111-25. Pubmed Link
Tesmer JJ (2009). Chapter 4: Structure and function of regulator of G protein signaling homology domains. Prog Mol Biol Transl Sci. 86:75-113. Pubmed Link
Sterne-Marr R, Dhami GK, Tesmer JJ, & Ferguson SSG. (2004). Characterization of GRK2 RH domain-dependent regulation of GPCR coupling to heterotrimeric G proteins. Methods in Enzymology, 390: 310-336.
Tesmer, J. J. G., Sunahara, R. K., Fancy, D. A., Gilman, A. G., & Sprang, S. R. (2002). Crystallization of complex between soluble domains of adenylyl cyclase and activated G(s)α. Methods in Enzymology, 345:198-206.
Dessauer CW, Tesmer JJ, Sprang SR, & Gilman AG (1999). The interactions of adenylate cyclases with P-site inhibitors. Trends in Pharmacological Sciences, 20: 205-210.
Tesmer JJ, Sprang SR (1998): Structure, catalytic mechanism and regulation of adenylyl cyclase. Curr. Opin. Struct. Biol. 8:713-719.
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Editorial Material
Tesmer J.J.G. (2008). Guanylyl cyclase sees the light. J Biol., 7, 31. Pubmed Link
Tesmer, J. J. G. (2006). Hitting the hot spots of cell signaling cascades. Science, 312, 377-378.
Abstract | Full Text
Tesmer, J. J. G. (2005). A seminal study of soluble adenylyl cyclase. Nature Structural & Molecular Biology, 12, 7-8.
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Notes
Vermersch, P. S., Tesmer, J. J. G., & Quiocho, F. A. (1992). Protein ligand energetics assessed using deoxy and fluorodeoxy sugars in equilibrium binding and high-resolution crystallographic studies. Journal of Molecular Biology, 226, 923-929.
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