Publications
Recent Articles | Articles (1997-2005) | Articles (1989-1996) | Review Articles | Editorial Material | Notes
Recent Articles
Ding, Y., Greshock, T.J., Miller, K.A., and Sherman,.D.H, Williams, R.M.2008. Premalbrancheamide:Synthesis, Isotopic Labeling, Biosynthetic Incorporation, and Detection in Cultures of Malbranchea aurantiaca Org. Letters 154(Pt10):2912-2919.PubMed Link
Hur, Y. A., Choi, S.S.,and Sherman,.D.H, Kim, E.-S.2008. Identification of TmcN as a pathway-specific positive regulator of tautomycetin biosynthesis in Streptomyces sp. CK4412. Microbiology 154(Pt10):2912-2919.PubMed Link
Anzai, Y., Li, S., Chaulagain, M. R., Kinoshita, K., Kato, F., Montgomery, J., and Sherman D. H., 2008. 2008. Functional analysis of MycCI and MycG, cytochrome P450 enzymes involved in biosynthesis of mycinamicin macrolide antibiotics Chem. Biol. 15(9):950-959. PubMed Link
Smith, J. L. and Sherman D. H., 2008. An enzyme assembly line. Science 321(5894):1304-1305.Science Link
Ding, Y., Gruschow, S., Greshock, T.J., Finefield, J.M., Sherman D. H., Williams, R.M. 2008. Detection of VM55599 and Preparaherquamide from Aspergillus japonicus and, Penicillium fellutanum: Biosynthetic Implications. J. Nat. Prod. Aug. 28 (Epub ahead of print)
Jayapal K.P., Philp R.J., Kok Y.J., Yap M.G., Sherman D. H. ,Griffin T.J., and Hu W.-S. 2008. Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor. PLoS ONE. 3(5):e2097. PubMed Link
Ding Y., Williams R.M., and Sherman D. H. 2008. Molecular analysis of a 4-dimethylallyltryptophan synthase from malbranchea aurantiaca. J. Biol. Chem. 283(23):16068-16076. PubMed Link
Ding Y., Seufert W., Beck Z.Q., and Sherman D. H. 2008. Analysis of the cryptophycin P450 epoxidase reveals substrate tolerance and cooperativity. J. Amer. Chem. Soc. 130(16):5492-5498. PubMed Link
Miller K.A., Welch T.R., Greshock T.J.,Ding Y., Sherman D. H., and Williams R.M. 2008. Biomimetic total synthesis of malbrancheamide and malbrancheamide B. J. Org. Chem. 73(8):3116-3119. PubMed Link
Lian W., Jayapal K.P., Charaniya S., Mehra S., Glod F., Kyung Y. S., Sherman D. H., and Hu W.-S. 2008. Genome-wide transcriptome analysis reveals that a pleiotropic antibiotic regulator, AfsS, modulates nutritional stress response in Streptomyces coelicolor A3(2). BMC Genomics, Jan 29;9(1): 56.) PubMed Link
Lee J.Y., Sherman D.H. , and Hwang B. K. 2008. In vitro antimicrobial and in vivo antioomycete activities of the novel antibiotic thiobutacin. Pest. Manag. Sci. 64(2):172-177. PubMed Link
Buchholz T.J., Kittendorf J.D., and Sherman D. H. 2007. Polyketide biosynthesis, modular polyketide synthases. Wiley Encyclopedia of Chemical Biology (In press).
Gu L.C., Geders T.W., Wang B., Gerwick W.H., Håkansson K., Smith J. L., and Sherman D.H.. 2007. GNAT-like strategy for polyketide chain initiation. Science 318(5852):970-974. Link to Science Magazine
Geders T.W., Gu L.C., Mowers J.C., Liu H., Gerwick W.H., Håkansson K., Sherman D. H. , Smith J.L. 2007. Crystal structure of the ECH2 catalytic domain of CurF from Lyngbya majuscula: Insights into a decarboxylase involved in polyketide chain b-branching. J. Biol. Chem. 282(49): 35954-35963. PubMed Link
Li S., Podust L.M., and Sherman D. H. 2007. Engineering and analysis of a self-sufficient biosynthetic cytochrome P450 PikC fused to the RhFRED reductase domain. J. Amer. Chem. Soc. 129: 12940-12941. PubMed Link
Seufert W., Beck Z.Q., and Sherman D. H. 2007. Enzymatic release and macrolactonization of cryptophycins from safety-catch solid support. Angewandte Chemie 46: 9298-9300. PubMed Link
Kittendorf J. D., Beck B. J., Buchholz T. J. and Sherman D. H. 2007. Interrogating the molecular basis for multiple macrolactone ring formation by the pikromycin polyketide synthase. Chemistry & Biology 14: 944-954. PubMed Link
Beck Z. Q., Burr D. A. and Sherman D. H. 2007. Characterization of the b-methylaspartate-a-decarboxylase (CrpG) from the cryptophycin biosynthetic pathway. ChemBioChem 8(12): 1373-1375. PubMed Link
Jayapal, K.P., Lian, W., Glod, F., Sherman, D.H. and Hu, W.S. 2007. Comparative genomic hybridizations reveal absence of large Streptomyces coelicolor genomic islands in Streptomyces lividans. BMC Genomics 2007 Jul 10;8(1):229.PubMed Link
Oh, H.-S., Yun, J.-S., Nah, K.-H., Kang, H.-Y. and Sherman D. H. Synthesis of the tetraketide lactones from the pikromycin biosynthetic pathway. Eur. J. Org. Chem. 2007 3369–3379.
Sitachitta N., Lopanik N. B., Mao, Y., Sherman D.H. 2007. Analysis of a parallel branch in the mitomycin biosynthetic pathway involving the mitn-encoded aziridine n-methyltransferase. J. Biol. Chem. 2007 May 16; PubMed Link
Kwon S. J., Lee M.-Y., Ku B., Sherman D. H., and Dordick J. S.. 2007. High-throughput, microarray-based Synthesis of natural product Analogs via in vitro metabolic pathway construction. ACS Chemical Biology 2007 May 25; PubMed Link
Grüschow S., Chang L.C., Mao Y., and Sherman D.H. 2007. Hydroxyquinone O-methylation in mitomycin biosynthesis. J. Amer. Chem. Soc. 129:6470-6476. PubMed Link
Grüschow S., Buchholz T.J., Seufert W., Dordick J.S., and Sherman D.H. 2007. Substrate profile analysis and ACP-mediated acyl transfer in Streptomyces coelicolor type III polyketide synthases. Chembiochem. 8:863-868. PubMed Link
Passalacqua K.D., Bergman N.H., Lee J.Y., Sherman D.H., and Hanna P.C. 2007. The global transcriptional responses of Bacillus anthracis Sterne (34F2) and δsodA1 to paraquat reveal metal ion homeostasis imbalances during endogenous superoxide stress. J Bacteriol. 189:3996-4013.PubMed Link
Liu H., Håkansson K., Lee J.Y., and Sherman D.H. 2007. Collision-activated dissociation, infrared multiphoton dissociation, and electron capture dissociation of the Bacillus anthracis siderophore petrobactin and its metal ion complexes. Journal of the American Society for Mass Spectrometry 18:842-849.PubMed Link
Choi, S.-S., Hur, Y.-A., Sherman, D.H., and E.-S. Kim. 2007. Isolation of the biosynthetic gene cluster for tautomycetin, a linear polyketide T cell-specific immunomodulator from Streptomyces sp. CK4412. Microbiology 153:1095-1102.PubMed Link
Pfleger B. F., Lee, J.Y., Somu, R.V., Aldrich, C.C., Hanna, P.C., and D. H. Sherman. 2007. Characterization and analysis of early enzymes for petrobactin biosynthesis in Bacillus anthracis. Biochemistry 46:4147-4157.PubMed Link
Li, S., Grüschow, S., Dordick, J.S., and Sherman, D.H. 2007. Molecular analysis of the role of tyrosine 224 in the active site of Streptomyces coelicolor RppA, a bacterial type III polyketide synthase. J. Biol. Chem. 2007 Mar 1; [Epub ahead of print].Link
Sudek S., Lopanik N.B., Waggoner L.E., Hildebrand M., Anderson C., Liu H., Patel A., Sherman, D.H. and Haygood M.G. 2007. Identification of the putative bryostatin polyketide synthase gene cluster from “Candidatus Endobugula sertula”, the uncultivated microbial symbiont of the marine bryozoan Bugula neritina. J. Nat. Prod. 70:67-74.PubMed Link
Lee J.Y., Janes B.K., Passalacqua K.D., Pfleger B., Bergman N.H., Liu H., Håkansson K., Somu R.V., Aldrich C.C., Cendrowski S., Hanna P.C., Sherman, D.H. 2007. Biosynthetic analysis of the petrobactin siderophore pathway from Bacillus anthracis. J. Bacteriol. 189:1698-1710.PubMed Link
Magarvey N.A., Beck Z.Q., Golakoti T., Ding Y., Huber U., Hemscheidt T.K., Abelson D., Moore R.E., and Sherman D.H. 2006. Biosynthetic characterization and chemoenzymatic assembly of the cryptophycins. Potent anticancer agents from Nostoc cyanobionts. ACS Chem. Biol.
1:766-779. Link
Venkatraman, L, Salomon, C.E., Sherman, D.H., Fecik, R.A. 2006. Total synthesis of narbonolide and biotransformation to pikromycin. J. Org. Chem Note 71:9853-9856. PubMed Link
Kittendorf, J.D., Sherman, D. H. (2006). Developing tools for engineering hybrid polyketide synthetic pathways.Curr Opin Biotechnol. 17:597-605. PubMed Link
Giraldes, J.W., Akey, D.L., Kittendorf, J.D., Sherman, D.H. , Smith, J.L., Fecik, R.A. 2006. Structural and mechanistic insights of polyketide macrolactonization from polyketide-based affinity labels. Nature Chemical Biology. 2:531-536. PubMed Link
Akey, D.L., Kittendorf, J.D., Giraldes, J.W., Fecik, R.A., Sherman, D.H. , Smith, J.L. 2006. Structural basis for macrolactonization by the pikromycin thioesterase. Nature Chemical Biology. 2:537-542. PubMed Link
Sherman, D.H. and Smith, J.L. 2006. Clearing the skies over modular polyketide synthases. ACS Chem. Biol. 1:505-509. PubMed Link
Sherman, D.H. ; Li, S.; Yermalitskaya, L.V.; Kim, Y.; Smith, J.A.; Waterman, M.R.; Podust, L.M. 2006. The structural basis for substrate anchoring, active site selectivity, and product formation by P450 PikC from Streptomyces venezuelae. J Biol Chem. 281(36):26289-97. PubMed Link
Ku, B.; Cha, J.; Srinivasan, A.; Kwon, S.J.; Jeong, J.C.; Sherman, D.H. ; Dordick, J.S. 2006. Chip-based polyketide biosynthesis and functionalization. Biotechnol Prog. 22(4):1102-7. PubMed Link
Beck, Z. Q., & Sherman, D. H. (2006). Development of an internally quenched fluorogenic substrate for kinetic analysis of thioesterases. Analytical Biochemistry, 349, 309-311. PubMed Link
Mehra, S., Lian, W., Jayapal, K. P., Charaniya, S. P., Sherman, D. H., & Hu, W. S. (2006). A framework to analyze multiple time series data: A case study with Streptomyces coelicolor. Journal of Industrial Microbiology & Biotechnology, 33, 159-172. PubMed Link
Lee, S. K., Park, J. W., Kim, J. W., Jung, W. S., Park, S. R., Choi, C. Y., Kim, E. S., Kim, B. S., Ahn, J. S., Sherman, D. H., & Yoon, Y. J. (2006). Neopikromycin and novapikromycin from the pikromycin biosynthetic pathway of Streptomyces venezuelae. Journal of Natural Products, 69, 847-849. PubMed Link
Flatt, P. M., O'Connell, S. J., McPhail, K. L., Zeller, G., Willis, C. L., Sherman, D. H., & Gerwick, W. H. (2006). Characterization of the initial enzymatic steps of barbamide synthesis. Journal of Natural Products, 69, 938-944. PubMed Link
Jung WS, Lee SK, Hong JS, Park SR, Jeong SJ, Han AR, Sohng JK, Kim BG, Choi CY, Sherman DH, Yoon YJ. 2006. Heterologous expression of tylosin polyketide synthase and production of a hybrid bioactive macrolide in Streptomyces venezuelae. Appl Microbiol Biotechnol. 72(4):763-9.PubMed Link
Nishizawa, T., Gruschow, S., Jayamaha, D. H. E., Nishizawa-Harada, C., & Sherman, D. H. (2006). Enzymatic assembly of the bis-indole core of rebeccamycin. Journal of the American Chemical Society, 128, 724-725. PubMed Link
Gu, L. C., Jia, J. Y., Liu, H. C., Hakansson, K., Gerwick, W. H., & Sherman, D. H. (2006). Metabolic coupling of dehydration and decarboxylation in the curacin A pathway: Functional identification of a mechanistically diverse enzyme pair. Journal of the American Chemical Society, 128, 9014-9015. PubMed Link
Articles (1997-2005)
Beck, Z. Q., Aldrich, C. C., Magarvey, N. A., Georg, G. I., & Sherman, D. H. (2005). Chemoenzymatic synthesis of cryptophycin/arenastatin natural products. Biochemistry, 44, 13457-13466. PubMed Link
Nishizawa, T., Aldrich, C. C., & Sherman, D. H. (2005). Molecular analysis of the rebeccamycin L-amino acid oxidase from Lechevalieria aerocolonigenes ATCC 39243. Journal of Bacteriology, 187, 2084-2092. PubMed Link
Venkatraman, L., Aldrich, C. C., Sherman, D. H., & Fecik, R. A. (2005). Formal total synthesis of the polyketide macrolactone narbonolide. Journal of Organic Chemistry, 70, 7267-7272. PubMed Link
Jeong, J. C., Srinivasan, A., Grüschow, S., Bach, H., Sherman, D. H., & Dordick, J. S. (2005). Exploiting the reaction flexibility of a type III polyketide synthase through in vitro pathway manipulation. Journal of the American Chemical Society, 127, 64-65. Pub Med Link
Aldrich, C. C., Beck, B. J., Fecik, R. A., & Sherman, D. H. (2005). Biochemical investigation of pikromycin biosynthesis employing native penta- and hexaketide chain elongation intermediates. Journal of the American Chemical Society, 127, 8441-8452. PubMed Link
Aldrich, C. C., Venkatraman, L., Sherman, D. H., & Fecik, R. A. (2005). Chemoenzymatic synthesis of the polyketide macrolactone 10-deoxymethynolide. Journal of the American Chemical Society, 127, 8910-8911. PubMed Link
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Magarvey, N. A., Keller, J. M., Bernan, V., Dworkin, M., & Sherman, D. H. (2004). Isolation and characterization of novel marine-derived actinomycete taxa rich in bioactive metabolites. Applied and Environmental Microbiology, 70, 7520-7529. Pub Med Link
Srinivasan A., Bach H., Sherman, D. H., & Dordick, J. S. (2004). Bacterial P450-catalyzed polyketide hydroxylation on a microfluidic platform. Biotechnology & Bioengineering, 88, 528-535. Pub Med Link
Hildebrand, M., Waggoner, L. E., Liu, H. B., Sudek, S., Allen, S., Anderson, C., Sherman, D. H., & Haygood, M. (2004). bryA: An unusual modular polyketide synthase gene from the uncultivated bacterial symbiont of the marine bryozoan Bugula neritina. Chemistry & Biology, 11, 1543-1552. Pub Med Link
Chang, Z. X., Sitachitta, N., Rossi, J. V., Roberts, M. A., Flatt, P. M., Jia, J. Y., Sherman, D. H., & Gerwick, W. H. (2004). Biosynthetic pathway and gene cluster analysis of curacin A, an anti-tubulin natural product from the tropical marine cyanobacterium Lyngbya majuscula. Journal of Natural Products, 67, 1356-1367. Pub Med Link
Kim, B. S., Sherman, D. H., & Reynolds, K. A. (2004). An efficient method for creation and functional analysis of libraries of hybrid type I polyketide synthases. Protein Engineering, Design and Selection, 17, 277-284. Pub Med Link
Podust, L. M., Bach, H., Kim, Y., Lamb, D. C., Arase, M., Sherman, D. H., Kelly, S. L., & Waterman, M. R. (2004). Comparison of the 1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2) with the closely related CYP154C1 and CYPs from antibiotic biosynthesis pathways. Protein Science, 13, 255-268.
Podust, L. M., Kim, Y., Arase, M., Neely, B. A., Beck, B. J., Bach, H., Sherman, D. H., Lamb, D. C., Kelly, S. L., & Waterman, M. R. (2003). The 1.92-angstrom structure of Streptomyces coelicolor A3(2) CYP154C1 - A new mono-oxygenase that functionalizes macrolide ring systems. Journal of Biological Chemistry, 278, 12214-12221.
Jung, W. S., Kim, E. S., Kang, H. Y., Choi, C. Y., Sherman, D. H., & Yoon, Y. J. (2003). Site-directed mutagenesis on putative macrolactone ring size determinant in the hybrid pikromycin-tylosin polyketide synthase. Journal of Microbiology and Biotechnology, 13, 823-827.
Beck, B. J., Aldrich, C. C., Fecik, R. A., Reynolds, K. A., & Sherman, D. H. (2003). Iterative chain elongation by a pikromycin monomodular polyketide synthase. Journal of the American Chemical Society, 125, 4682-4683. Pub Med Link
Beck, B. J., Aldrich, C. C., Fecik, R. A., Reynolds, K. A., & Sherman, D. H. (2003). Substrate recognition and channeling activities of monomodules from the pikromycin polyketide synthase. Journal of the American Chemical Society, 125, 12551-12557. Pub Med Link
Kim, B. S., Cropp, T. A., Florova, G., Lindsay, Y., Sherman, D. H., & Reynolds, K. A. (2002). An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis. Biochemistry, 41, 10827-10833. Abstract
Baumann, R. P., Sherman, D. H., & Sartorelli, A. C. (2002). Novel selection marker for mammalian cell transfection. BioTechniques, 32, 1030-1036. Abstract
Yoon, Y. J., Beck, B. J., Kim, B. S., Kang, H. Y., Reynolds, K. A., & Sherman, D. H. (2002). Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae. Chemistry & Biology, 9, 203-214. Abstract
Beck, B. J., Yoon, Y. J., Reynolds, K. A., & Sherman, D. H. (2002). The hidden steps of domain skipping: Macrolactone ring size determination in the pikromycin modular polyketide synthase. Chemistry & Biology, 9, 575-583. Abstract
Chang, Z. X., Flatt, P., Gerwick, W. H., Nguyen, V. A., Willis, C. L., & Sherman, D. H. (2002). The barbamide biosynthetic gene cluster: A novel marine cyanobacterial system of mixed polyketide synthase (PKS) non-ribosomal peptide synthetase (NRPS) origin involving an unusual trichloroleucyl starter unit. Gene, 296, 235-247. Abstract
Kim, B. S., Cropp, T. A., Beck, B. J., Sherman, D. H., & Reynolds, K. A. (2002). Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin. Journal of Biological Chemistry, 277, 48028-48034. Full Paper Link
Martin, T. W., Dauter, Z., Devedjiev, Y., Sheffield, P., Jelen, F., He, M., Sherman, D. H., Otlewski, J., Derewenda, Z. S., & Derewenda, U. (2002). Molecular basis of mitomycin C resistance in Streptomyces: Structure and function of the MRD protein. Structure, 10, 933-942. Pub Med Link
Kyung, Y. S., Sherman, D. H., & Hu, W. S. (2001). Simultaneous analysis of spatio-temporal gene expression for cephamycin biosynthesis in Streptomyces clavuligerus. Biotechnology Progress, 17, 1000-1007. Abstract
Baumann, R. P., Hodnick, W. F., Seow, H. A., Belcourt, M. F., Rockwell, S., Sherman, D. H., & Sartorelli, A. C. (2001). Reversal of mitomycin C resistance by overexpression of bioreductive enzymes in Chinese hamster ovary cells. Cancer Research, 61, 7770-7776. Pub Med Link
Chen, S., Roberts, J. B., Xue, Y. Q., Sherman, D. H., & Reynolds, K. A. (2001). The Streptomyces venezuelae pikAV gene contains a transcription unit essential for expression of enzymes involved in glycosylation of narbonolide and 10-deoxymethynolide. Gene, 263, 255-264. Abstract
Wilson, D. J., Xue, Y. Q., Reynolds, K. A., & Sherman, D. H. (2001). Characterization and analysis of the PikD regulatory factor in the pikromycin biosynthetic pathway of Streptomyces venezuelae. Journal of Bacteriology, 183, 3468-3475. Full Paper Link
Penketh, P. G., Hodnick, W. F., Belcourt, M. F., Shyam, K., Sherman, D. H., & Sartorelli, A. C. (2001). Inhibition of DNA cross-linking by mitomycin C by peroxidase-mediated oxidation of mitomycin C hydroquinone. Journal of Biological Chemistry, 276, 34445-34452. Full Paper Link
Varoglu, M., Mao, Y. Q., & Sherman, D. H. (2001). Mapping the mitomycin biosynthetic pathway by functional analysis of the MitM aziridine N-methyltransferase. Journal of the American Chemical Society, 123, 6712-6713. Pub Med Link
Kyung, Y. S., Hu, W. S., & Sherman, D. H. (2001). Analysis of temporal and spatial expression of the CcaR regulatory element in the cephamycin C biosynthetic pathway using green fluorescent protein. Molecular Microbiology, 40, 530-541. Pub Med Link
He, M., Sheldon, P. J., & Sherman, D. H. (2001). Characterization of a novel quinone reductase activity for the mitomycin C binding protein (MRD): Functional switching from a drug-activating enzyme to a drug-binding protein. Proceedings of the National Academy of Sciences of the USA, 98, 926–931. Pub Med Link
Kim, S. J., Kang, H. Y., & Sherman, D. H. (2001). Synthesis of triketide delta-lactones. Synthesis, 12, 1790-1793.
Chen, S., Xue, Y. Q., Sherman, D. H., & Reynolds, K. A. (2000). Mechanisms of molecular recognition in the pikromycin polyketide synthase. Chemistry & Biology, 7, 907-918. Pub Med Link
Xue, Y. Q., Wilson, D., & Sherman, D. H. (2000). Genetic architecture of the polyketide synthases for methymycin and pikromycin series macrolides. Gene, 245, 203-211. Pub Med Link
He, M., Varoglu, M., & Sherman, D. H. (2000). Structural modeling and site-directed mutagenesis of the actinorhodin beta-ketoacyl-acyl carrier protein synthase. Journal of Bacteriology, 182, 2619-2623. Full Paper Link
Khetan, A., Hu, W. S., & Sherman, D. H. (2000). Heterogenous distribution of lysine 6-aminotransferase during cephamycin C biosynthesis in Streptomyces clavuligerus demonstrated using green fluorescent protein as a reporter. Microbiology, 146, 1869-1880. Full Paper Link
Xue, Y. Q., & Sherman, D. H. (2000). Alternative modular polyketide synthase expression controls macrolactone structure. Nature, 403, 571-575. Pub Med Link
Khetan, A., Malmberg, L. H., Kyung, Y. S., Sherman, D. H., & Hu, W. S. (1999). Precursor and cofactor as a check valve for cephamycin biosynthesis in Streptomyces clavuligerus. Biotechnology Progress, 15, 1020-1027. Pub Med Link
Mao, Y. Q., Varoglu, M., & Sherman, D. H. (1999). Genetic localization and molecular characterization of two key genes (mitAB) required for biosynthesis of the antitumor antibiotic mitomycin C. Journal of Bacteriology, 181, 2199-2208. Pub Med Link
Sheldon, P. J., Mao, Y. Q., He, M., & Sherman, D. H. (1999). Mitomycin resistance in Streptomyces lavendulae includes a novel drug-binding protein-dependent export system. Journal of Bacteriology, 181, 2507-2512. Pub Med Link
Zhao, L. S., Ahlert, J., Xue, Y. Q., Thorson, J. S., Sherman, D. H., & Liu, H. W. (1999). Engineering a methymycin/pikromycin calicheamicin hybrid: Construction of two new macrolides carrying a designed sugar moiety. Journal of the American Chemical Society, 121, 9881-9882.
Han, L., Khetan, A., Hu, W. S., & Sherman, D. H. (1999). Time-lapsed confocal microscopy reveals temporal and spatial expression of lysine epsilon-aminotransferase gene in Streptomyces clavuligerus. Molecular Microbiology, 34, 878-886. Pub Med Link
Borisova, S. A., Zhao, L. S., Sherman, D. H., & Liu, H. W. (1999). Biosynthesis of desosamine: Construction of a new macrolide carrying a genetically designed sugar moiety. Organic Letters, 1, 133-136. Pub Med Link
Belcourt, M. F., Penketh, P. G., Hodnick, W. F., Johnson, D. A., Sherman, D. H., Rockwell, S., & Sartorelli, A. C. (1999). Mitomycin resistance in mammalian cells expressing the bacterial mitomycin C resistance protein MCRA. Proceedings of the National Academy of Sciences of the USA, 96, 10489-10494. Full Paper Link
Xue, Y. Q., Wilson, D., Zhao, L. S., Liu, H. W., & Sherman, D. H. (1998). Hydroxylation of macrolactones YC-17 and narbomycin is mediated by the pikC-encoded cytochrome P450 in Streptomyces venezuelae. Chemistry & Biology, 5, 661-667. Pub Med Link
Bedeker, A., Zink, R. M., Sherman, D. H., Line, T. V., & Van Pilsum, J. F. (1998). The comparative amino acid sequences, substrate specificities and gene or cDNA nucleotide sequences of some prokaryote and eukaryote amidinotransferases: Implications for evolution. Comparative Biochemistry and Physiology, 119, 677-690. Pub Med Link
Zhao, L., Sherman, D. H., & Liu, H. W. (1998). Biosynthesis of desosamine: Molecular evidence suggesting ß-glucosylation as a self-resistance mechanism in methymycin/neomethymycin producing strain, Streptomyces venezuelae. Journal of the American Chemical Society, 120, 9374-9375.
Zhao, L. S., Sherman, D. H., & Liu, H. W. (1998). Biosynthesis of desosamine: Construction of a new methymycin/neomethymycin analogue by deletion of a desosamine biosynthetic gene. Journal of the American Chemical Society, 120, 10256-10257.
Zhao, L. S., Que, N. L. S., Xue, Y. Q., Sherman, D. H., & Liu, H. W. (1998). Mechanistic studies of desosamine biosynthesis: C-4 deoxygenation precedes C-3 transamination. Journal of the American Chemical Society, 120, 12159-12160.
Xue, Y. Q., Zhao, L. S., Liu, H. W., & Sherman, D. H. (1998). A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: Architecture of metabolic diversity. Proceedings of the National Academy of Sciences of the USA, 95, 12111-12116. Full Article Link
Sheldon, P. J., Johnson, D. A., August, P. R., Liu, H. W., & Sherman, D. H. (1997). Characterization of a mitomycin-binding drug resistance mechanism from the producing organism, Streptomyces lavendulae. Journal of Bacteriology, 179, 1796-1804. [Correction: 179, 4080.]
Johnson, D. A., August, P. R., Shackleton, C., Liu, H. W., & Sherman, D. H. (1997). Microbial resistance to mitomycins involves a redox relay mechanism. Journal of the American Chemical Society, 119, 2576-2577.
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Articles (1989-1996)
Khetan, A., Malmberg, L. H., Sherman, D. H., & Hu, W. S. (1996). Metabolic engineering of cephalosporin biosynthesis in Streptomyces clavuligerus. Annals of the New York Academy of Sciences, 782, 17-24.
Williams, M. D., Rahn, J. A., & Sherman, D. H. (1996). Production of a polyhydroxyalkanoate biopolymer in insect cells with a modified eukaryotic fatty acid synthase. Applied and Environmental Microbiology, 62, 2540-2546. [Correction 64, 383.]
August, P. R., Rahn, J. A., Flickinger, M. C., & Sherman, D. H. (1996). Inducible synthesis of the mitomycin C resistance gene product (MCRA) from Streptomyces lavendulae. Gene, 175, 261-267.
Williams, M. D., Fieno, A. M., Grant, R. A., & Sherman, D. H. (1996). Expression and analysis of a bacterial poly(hydroxyalkanoate) synthase in insect cells using a baculovirus system. Protein Expression and Purification, 7, 203-211.
Malmberg, L. H., Hu, W. S., & Sherman, D. H. (1995). Effects of enhanced lysine epsilon-aminotransferase activity on cephamycin biosynthesis in Streptomyces clavuligerus. Applied Microbiology and Biotechnology, 44, 198-205.
Crosby, J., Sherman, D. H., Bibb, M. J., Revill, W. P., Hopwood, D. A., & Simpson, T. J. (1995). Polyketide synthase acyl carrier proteins from Streptomyces - Expression in Escherichia coli, purification and partial characterization. Biochimica et Biophysica Acta, 1251, 32-42.
Kim, E. S., Cramer, K. D., Shreve, A. L., & Sherman, D. H. (1995). Heterologous expression of an engineered biosynthetic pathway - Functional dissection of type II polyketide synthase components in Streptomyces species. Journal of Bacteriology, 177, 1202-1207.
Bibb, M. J., Sherman, D. H., Omura, S., & Hopwood, D. A. (1994). Cloning, sequencing and deduced functions of a cluster of Streptomyces genes probably encoding biosynthesis of the polyketide antibiotic frenolicin. Gene, 142, 31-39.
Khosla, C., McDaniel, R., Ebert-Khosla, S., Torres, R., Sherman, D. H., Bibb, M. J., & Hopwood, D. A. (1993). Genetic construction and functional analysis of hybrid polyketide synthases containing heterologous acyl carrier proteins. Journal of Bacteriology, 175, 2197-2204.
Malmberg, L. H., Hu, W. S., & Sherman, D. H. (1993). Precursor flux control through targeted chromosomal insertion of the lysine epsilon-aminotransferase (LAT) gene in cephamycin C biosynthesis. Journal of Bacteriology, 175, 6916-6924.
Malmberg, L. H., Sherman, D. H., & Hu, W. S. (1992). Analysis of rate-limiting reactions in cephalosporin biosynthesis. Annals of the New York Academy of Sciences, 665, 16-26.
Sherman, D. H., Kim, E. S., Bibb, M. J., & Hopwood, D. A. (1992). Functional replacement of genes for individual polyketide synthase components in Streptomyces coelicolor A3(2) by heterologous genes from a different polyketide pathway. Journal of Bacteriology, 174, 6184-6190.
Arrowsmith, T. J., Malpartida, F., Sherman, D. H., Birch, A., Hopwood, D. A., & Robinson, J. A. (1992). Characterization of acti-homologous DNA encoding polyketide synthase genes from the monensin producer Streptomyces cinnamonensis. Molecular & General Genetics, 234, 254-264.
Sherman, D. H., Bibb, M. J., Simpson, T. J., Johnson, D., Malpartida, F., Fernandez-Moreno, M., Martinez, E., Hutchinson, C. R., & Hopwood, D. A. (1991). Molecular genetic analysis reveals a putative bifunctional polyketide cyclase dehydrase gene from Streptomyces coelicolor and Streptomyces violaceoruber, and a cyclase o-methyltransferase from Streptomyces glaucescens. Tetrahedron, 47, 6029-6043.
Sherman, D. H., Malpartida, F., Bibb, M. J., Kieser, H. M., & Hopwood, D. A. (1989). Structure and deduced function of the granaticin-producing polyketide synthase gene cluster of Streptomyces violaceoruber TU22. EMBO Journal, 8, 2717-2725.
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Review Articles
Fortman, J. L., & Sherman, D. H. (2005). Utilizing the power of microbial genetics to bridge the gap between the promise and the application of marine natural products. Chembiochem, 6, 960-978. PubMed Link
Salomon, C. E., Magarvey, N. A., & Sherman, D. H. (2004). Merging the potential of microbial genetics with biological and chemical diversity: An even brighter future for marine natural product drug discovery. Natural Product Reports, 21, 105-121.
Cropp, T. A., Kim, B. S., Beck, B. J., Yoon, Y. J., Sherman, D. H., & Reynolds, K. A. (2002). Recent developments in the production of novel polyketides by combinatorial biosynthesis. Biotechnology & Genetic Engineering Reviews, 19, 159-172.
Xue, Y. Q., & Sherman, D. H. (2001). Biosynthesis and combinatorial biosynthesis of pikromycin-related macrolides in Streptomyces venezuelae. Metabolic Engineering, 3, 15-26.
Mao, Y. Q., Varoglu, M., & Sherman, D. H. (1999). Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564. Chemistry & Biology, 6, 251-263.
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Editorial Material
Sherman, D. H. (2005). The lego-ization of polyketide biosynthesis. Nature Biotechnology, 23, 1083-1084. PubMed Link
Sherman, D. H. (2002). New enzymes for "warheads". Nature Biotechnology, 20, 984-985.
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Notes
Kim, E. S., Bibb, M. J., Butler, M. J., Hopwood, D. A., & Sherman, D. H. (1994). Sequences of the oxytetracycline polyketide synthase encoding OTC genes from Streptomyces rimosus. Gene, 141, 141-142.
Kim, E. S., Hopwood, D. A., & Sherman, D. H. (1994). Analysis of type II polyketide beta-ketoacyl synthase specificity in Streptomyces coelicolor A3(2) by trans complementatiion of actinorhodin synthase mutants. Journal of Bacteriology, 176, 1801-1804.
August, P. R., Flickinger, M. C., & Sherman, D. H. (1994). Cloning and analysis of a locus (MCR) involved in mitomycin C resistance in Streptomyces lavendulae. Journal of Bacteriology, 176, 4448-4454.
Stork, G., & Sherman, D. H. (1982). Efficient de novo construction of the indanpropionic acid precursor of 11-keto steroids - An improved internal diels-alder sequence. Journal of the American Chemical Society, 104, 3758-3759.
