Dr. Sherman's research efforts over the past decade have
evolved into several programs that are distinct in focus, yet coalesce
into an overriding theme that include molecular genetic, biochemical
and bioorganic chemical studies of microbial natural product
biosynthesis.

Metabolic engineering and combinatorial biosynthesis are
powerful approaches for harnessing the tremendous metabolic
capabilities of microorganisms, including primary and secondary
pathways. New genomic-based technologies are considerably enhancing the ability to understand and manipulate complex biosynthetic systems and will enable vast new opportunities in
medicine and industry.