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MORRISON LAB

Selected Publications

Quintana, E., M. Shackleton, M. Sabel, D.Fullen, T.M. Johnson, and S.J. Morrison. 2008. Efficient tumor formation by single human melanoma cells. Nature 456:593-598.PubMed Link

Levi B.P., O.H. Yilmaz, G. Duester, and S.J. Morrison. 2008. Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood In Press (available online).PubMed Link

Nishino, J., I. Kim, K. Chada, and S.J. Morrison. 2008. Hmga2 promotes neural stem cell self-renewal in young, but not old, mice by reducing p16 Ink4a and p19Arf expression. Cell 135: 227-239.PubMed Link

Kiel M.J., O.H. Yilmaz and S.J. Morrison. 2008. CD150- cells are transiently reconstituting multipotent progenitors with little or no stem cell activity. Blood 111: 4413-4. PubMed Link

Kiel, M.J. and S.J. Morrison. 2008. Uncertainty in the niches that maintain haematopoietic stem cells. Nature Reviews Immunology 8: 290-301.PubMed Link

Morrison, S.J. and A. Spradling. 2008. Stem Cells and Niches: Mechanisms that promote stem cell maintenance throughout life. Cell 132: 598-611.PubMed Link

Joseph, N.M., J.T. Mosher, J. Buchstaller, P. Snider, P.E. McKeever, M. Lim, S. J. Conway, L.F. Parada, Y. Zhu, and S. J. Morrison. 2008. The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell 13: 129-140.PubMed Link

Zhang, Y., S. N. Zolov, C.Y. Chow, S.G. Slutsky, S.C. Richardson, R.C. Piper, B. Yang, J.J. Nau, R.J. Westrick, S.J. Morrison, M.H. Meisler, and L.S. Weisman. 2007. Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proceedings of the National Academy of Sciences USA 104:17518-17523. PubMed Link

Kiel, M., He, S., Ashkenazi, R., Gentry, S.N., Teta, M., Kushner, J.A., Jackson, T.L., & Morrison, S.J. (2007). Hematopoietic stem cells do not asymmetrically segregate chromosomes or retain bromodeoxyuridine. Nature 449, 238-242 PubMed Link

Kim, I., Saunders, T.L., Morrison, S.J. Sox17 Dependence Distinguishes the Transcriptional Regulation of Fetal from Adult Hematopoietic Stem Cells. Cell (in press) PubMed Link

Molofsky, A.V., Slutsky, S.G., Joseph, N.M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N., & Morrison, S.J. (2006). Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443, 448-452 PubMed Link

Yilmaz, O. H., Valdez, R., Theisen, B. K., Guo, W., Ferguson, D. O., Wu, H., & Morrison, S. J. (2006). Pten dependence distinguishes hematopoietic stem cells from leukemia-initiating cells. Nature, 441, 475-482. PubMed Link

Morrison, S. J., & Kimble, J. (2006). Asymmetric and symmetric stem-cell divisions in development and cancer. Nature, 441, 1068-1074. PubMed Link

Joseph, N. M., & Morrison, S. J. (2005). Toward an understanding of the physiological function of mammalian stem cells. Developmental Cell, 9, 173-183. PubMed Link

Kiel, M. J., Yilmaz, O. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005). SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell, 121, 1109-1121. PubMed Link

Molofsky, A. V., He, S. H., Bydon, M., Morrison, S. J., & Pardal, R. (2005). Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16(Ink4a) and P19(Arf) senescence pathways. Genes & Development, 19, 1432-1437. PubMed Link

Pardal, R., Clarke, M. F., & Morrison, S. J. (2003). Applying the principles of stem-cell biology to cancer. Nature Reviews Cancer, 3, 895-902. PubMed Link

Molofsky, A. V., Pardal, R., Iwashita, T., Park, I. K., Clarke, M. F., & Morrison, S. J. (2003). Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature, 425, 962-967. PubMed Link

Alvarez-Dolado, M., Pardal, R., Garcia-Vardugo, J. M., Fike, J. R., Lee, H. O., Pfeffer, K., Lois, C., Morrison, S. J., & Alvarez-Buylla, A. (2003). Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature, 425, 968-973. PubMed Link

Iwashita, T., Kruger, G. M., Pardal, R., Kiel, M. J., & Morrison, S. J. (2003). Hirschsprung disease is linked to defects in neural crest stem cell function. Science, 301, 972-976. PubMed Link

Park, I. K., Qian, D. L., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003). Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature, 423, 302-305. PubMed Link

Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J., & Clarke, M. F. (2003). Prospective identification of tumorigenic breast cancer cells. Proceedings of the National Academy of Sciences of the USA, 100, 3983-3988. [Correction: 100, 6890.] PubMed Link

Kruger, G. M., & Morrison, S. J. (2002). Brain repair by endogenous progenitors. Cell, 110, 399-402. PubMed Link

Bixby, S., Kruger, G. M., Mosher, J. T., Joseph, N. M., & Morrison, S. J. (2002). Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity. Neuron, 35, 643-656. PubMed Link

Kruger, G. M., Mosher, J. T., Bixby, S., Joseph, N., Iwashita, T., & Morrison, S. J. (2002). Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness. Neuron, 35, 657-669. PubMed Link

Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001). Stem cells, cancer, and cancer stem cells. Nature, 414, 105-111. PubMed Link

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