Selected Publications
Quintana, E., M. Shackleton, M. Sabel, D.Fullen, T.M. Johnson, and S.J. Morrison. 2008. Efficient tumor formation by single human melanoma cells. Nature 456:593-598.PubMed Link
Levi B.P., O.H. Yilmaz, G. Duester, and S.J. Morrison. 2008. Aldehyde dehydrogenase 1a1 is dispensable for stem cell function in the mouse hematopoietic and nervous systems. Blood In Press (available online).PubMed Link
Nishino, J., I. Kim, K. Chada, and S.J. Morrison. 2008. Hmga2 promotes neural stem cell self-renewal in young, but not old, mice by reducing p16 Ink4a and p19Arf expression. Cell 135: 227-239.PubMed Link
Kiel M.J., O.H. Yilmaz and S.J. Morrison. 2008. CD150- cells are transiently reconstituting multipotent progenitors with little or no stem cell activity. Blood 111: 4413-4. PubMed Link
Kiel, M.J. and S.J. Morrison. 2008. Uncertainty in the niches that maintain haematopoietic stem cells. Nature Reviews Immunology 8: 290-301.PubMed Link
Morrison, S.J. and A. Spradling. 2008. Stem Cells and Niches: Mechanisms that promote stem cell maintenance throughout life. Cell 132: 598-611.PubMed Link
Joseph, N.M., J.T. Mosher, J. Buchstaller, P. Snider, P.E. McKeever, M. Lim, S. J. Conway, L.F. Parada, Y. Zhu, and S. J. Morrison. 2008. The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell 13: 129-140.PubMed Link
Zhang, Y., S. N. Zolov, C.Y. Chow, S.G. Slutsky, S.C. Richardson, R.C. Piper, B. Yang, J.J. Nau, R.J. Westrick, S.J. Morrison, M.H. Meisler, and L.S. Weisman. 2007. Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proceedings of the National Academy of Sciences USA 104:17518-17523. PubMed Link
Kiel, M., He, S., Ashkenazi, R., Gentry, S.N., Teta, M., Kushner, J.A., Jackson, T.L., & Morrison, S.J. (2007). Hematopoietic stem cells do not asymmetrically segregate chromosomes or retain bromodeoxyuridine. Nature 449, 238-242 PubMed Link
Kim, I., Saunders, T.L., Morrison, S.J. Sox17 Dependence Distinguishes the Transcriptional Regulation of Fetal from Adult Hematopoietic Stem Cells. Cell (in press) PubMed Link
Molofsky, A.V., Slutsky, S.G., Joseph, N.M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N., & Morrison, S.J. (2006). Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443, 448-452 PubMed Link
Yilmaz, O. H., Valdez, R., Theisen, B. K., Guo, W., Ferguson, D. O., Wu, H., & Morrison, S. J. (2006). Pten dependence distinguishes hematopoietic stem cells from leukemia-initiating cells. Nature, 441, 475-482. PubMed Link
Morrison, S. J., & Kimble, J. (2006). Asymmetric and symmetric stem-cell divisions in development and cancer. Nature, 441, 1068-1074. PubMed Link
Joseph, N. M., & Morrison, S. J. (2005). Toward an understanding of the physiological function of mammalian stem cells. Developmental Cell, 9, 173-183. PubMed Link
Kiel, M. J., Yilmaz, O. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005). SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells. Cell, 121, 1109-1121. PubMed Link
Molofsky, A. V., He, S. H., Bydon, M., Morrison, S. J., & Pardal, R. (2005). Bmi-1 promotes neural stem cell self-renewal and neural development but not mouse growth and survival by repressing the p16(Ink4a) and P19(Arf) senescence pathways. Genes & Development, 19, 1432-1437. PubMed Link
Pardal, R., Clarke, M. F., & Morrison, S. J. (2003). Applying the principles of stem-cell biology to cancer. Nature Reviews Cancer, 3, 895-902. PubMed Link
Molofsky, A. V., Pardal, R., Iwashita, T., Park, I. K., Clarke, M. F., & Morrison, S. J. (2003). Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature, 425, 962-967. PubMed Link
Alvarez-Dolado, M., Pardal, R., Garcia-Vardugo, J. M., Fike, J. R., Lee, H. O., Pfeffer, K., Lois, C., Morrison, S. J., & Alvarez-Buylla, A. (2003). Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature, 425, 968-973. PubMed Link
Iwashita, T., Kruger, G. M., Pardal, R., Kiel, M. J., & Morrison, S. J. (2003). Hirschsprung disease is linked to defects in neural crest stem cell function. Science, 301, 972-976. PubMed Link
Park, I. K., Qian, D. L., Kiel, M., Becker, M. W., Pihalja, M., Weissman, I. L., Morrison, S. J., & Clarke, M. F. (2003). Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature, 423, 302-305. PubMed Link
Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J., & Clarke, M. F. (2003). Prospective identification of tumorigenic breast cancer cells. Proceedings of the National Academy of Sciences of the USA, 100, 3983-3988. [Correction: 100, 6890.] PubMed Link
Kruger, G. M., & Morrison, S. J. (2002). Brain repair by endogenous progenitors. Cell, 110, 399-402. PubMed Link
Bixby, S., Kruger, G. M., Mosher, J. T., Joseph, N. M., & Morrison, S. J. (2002). Cell-intrinsic differences between stem cells from different regions of the peripheral nervous system regulate the generation of neural diversity. Neuron, 35, 643-656. PubMed Link
Kruger, G. M., Mosher, J. T., Bixby, S., Joseph, N., Iwashita, T., & Morrison, S. J. (2002). Neural crest stem cells persist in the adult gut but undergo changes in self-renewal, neuronal subtype potential, and factor responsiveness. Neuron, 35, 657-669. PubMed Link
Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001). Stem cells, cancer, and cancer stem cells. Nature, 414, 105-111. PubMed Link
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