May 24, 2007 - Jiandie Lin is featured twice in this month's issue of Nature for his discoveries related to the PGC-1α protein and its impact on circadian rhythms.
Download the profile of Lin and his research (PDF)
Download the "Metabolic Clockwork" article (PDF)
Most life on earth, whether simple or complex, flows with the universal hum of circadian rhythms. Our sleeping, eating, and the way we burn energy are all governed by the ticking of our body clocks in relation to light and dark cycles.
Besides making us feel alternatively tired or wakeful, this 24-hour rhythm pulses with biochemical reactions throughout the body, turning on and off genes that instruct the liver to pump glucose, synthesize cholesterol, or burn fat. However, the means by which these processes are coordinated has been a mystery, until now...
