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LIM LAB

Lim Publications

Articles and Reviews (1999 - Present) |

Independent Career

Articles and Reviews (1999 - Present)

  1. Braymer J. J.; O'Neill, K. P.; Rohde, J.-U.*; Lim, M. H.* Angew. Chem. Int. Ed. In Press (2012). "The Reaction of a High-Valent Nonheme Oxoiron(IV) Intermediate with Hydrogen Peroxide"

    onlinelibrary.wiley.com/doi/10.1002/anie.201200901/abstract

  1. He, X.; Park, H. M.; Hyung. S.-J.; DeToma, A. S.; Kim, C.; Ruotolo, B. T.; Lim, M. H.* Dalton Trans. In Press (2012). "Exploring the reactivity of Flavonoid Compounds with Metal-Associated Amyloid-β Species"

    pubs.rsc.org/en/Content/ArticleLanding/2012/DT/C2DT12207C

  1. Pithadia, A. S.; Lim, M. H.* Curr. Opin. Chem. Biol. 16, 67-73 (2012). "Metal-Associated Amyloid-β Species in Alzheimer's Disease"

    www.sciencedirect.com/science/article/pii/S1367593112000087

  1. Braymer, J. J.; Choi, J.-S.; DeToma, A. S.; Wang, C.; Nam, K.; Kampf, J. W.; Ramamoorthy, A.; Lim, M. H.* Inorg. Chem. 50, 10724-10734 (2011). "Development of Bifucntional Stilbene Derivatives for Targeting and Modulating Metal-Amyloid-β Species" 

    pubs.acs.org/doi/abs/10.1021/ic2012205

  1. Cho, J.; Jeon, S.; Wilson, S.; Liu, L. V.; Kang, E. A.; Braymer, J. J.; Lim, M. H.; Hedman, B.; Hodgson, K. O.; Valentine, J. S.; Solomon, E. I.; Nam, W. Nature 478, 502-505 (2011). "Structure, Interconversion, and Reactivity of Active Oxygen Ligands Bound to Nonheme Iron" 

    www.nature.com/nature/journal/v478/n7370/full/nature10535.html

  1. Braymer, J. J.; Merrill, N. M.; Lim, M. H.* Inorg. Chim. Acta (for the Special Issue of Future Young Investigators) 380, 261-268 (2012). "Characterization of Pyridinylimine and Pyridinylmethylamine Derivatives and Their Corresponding Metal Complexes" 

  1. Geldenhuys, W.; Ko, K. S.; Van der Schyf, C.*; Lim, M. H.* Med. Chem. Commun. 2, 1099-1103 (2011). "Identification of Multifunctional Small Molecule-Based Reversible Monoamine Oxidase Inhibitors" 

    pubs.rsc.org/en/content/articlelanding/2011/md/c1md00176k

  1. DeToma, A. S.#; Salamekh, S.#; Ramamoorthy, A.*; Lim, M. H.* Chem. Soc. Rev. 41, 608–621 (2012). "Misfolded Proteins in Alzheimer's Disease and Type II Diabetes" 

    (# Equal Contribution) pubs.rsc.org/en/content/articlelanding/2012/cs/c1cs15112f

  1. DeToma, A. S.#; Choi, J.-S.#; Braymer, J. J.; Lim, M. H.* ChemBioChem 12, 1198-201 (2011). "Myricetin, A Naturally Occurring Regulator of Metal-Induced Amyloid-β Aggregation and Neurotoxicity" (# Equal Contribution)

    onlinelibrary.wiley.com/doi/10.1002/cbic.201000790/abstract;jsessionid=B41FA110BF055C00758C3C9F8AD5669A.d02t02

  1. Choi, J.-S.; Braymer, J. J.; Park, S. K.; Mustafa,S.; Chae, J.*; Lim, M. H.* Metallomics 3, 284-291 (2011). "Synthesis and Characterization of IMPY Derivatives that Regulate Metal-Induced Amyloid-β Aggregation":

    Our Story was Selected for the Front Cover in This Issue!

    pubs.rsc.org/en/Content/ArticleLanding/2011/MT/C0MT00077A

  1. Braymer, J. J.#; DeToma, A. S.#; Choi, J.-S.; Ko, K. S.; Lim, M. H.* Int. J. Alzheimer's Disease (Special Issue on Metals and Alzheimer's Disease) 2011, 623051 (2011). "Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's Disease"

    (# Equal Contribution), www.sage-hindawi.com/journals/ijad/aip.623051.html

  1. Choi, J.-S.#; Braymer, J. J.#; Nanga, R. P. N.; Ramamoorthy, A.; Lim, M. H.* Proc. Natl. Acad. Sci. U.S.A. 107, 21990-21995 (2010). "Development of Small Molecules That Target Metal-Aβ Species and Regulate Metal-Induced Aβ Aggregation and Neurotoxicity"

    (# Equal Contribution), www.pnas.org/content/107/51/21990.abstract

            This article was highlighted in the scientific news.
            Chemical & Engineering News/University/AAQI
            (pubs.acs.org/isubscribe/journals/cen/88/i47/html/8847scic6.html )

  1. Hindo S. S.; Mancino, A. M.; Braymer, J. J.; Liu, Y.; Vivekanandan, S.; Ramamoorthy, A.*; Lim, M. H.* J. Am. Chem. Soc. 131, 16663–16665 (2009). "Small Molecule Modulators for Copper-Induced Aβ Aggregation"; pubs.acs.org/doi/full/10.1021/ja907045h

    This article was highlighted in the scientific news.
    (1)    University of Michigan and Life Sciences Institute. www.ns.umich.edu/htdocs/releases/story.php
    www.lsi.umich.edu/newsevents/discoveries/2009-11-03
    (2)    In ScienceDaily on Nov 6th, 2009. www.sciencedaily.com/releases/2009/11/091104101551.htm
    (3)    Other sites: http://www.medicalnewstoday.com/articles/169960.php
    www.timesoftheinternet.com/125897.html

  1. Mancino, A. M.; Hindo, S. S.; Kochi, A.; Lim, M. H.* Inorg. Chem. 48, 9596-9598 (2009). "Effects of Clioquinol on Metal-Triggered Amyloid-β Aggregation Revisited"; pubs.acs.org/doi/full/10.1021/ic9014256

MSc., Ph.D., and Postdoc.

  1. Lim, M. H.; Song, H.; Olmon, E. D.; Dervan, E. E.; Barton, J. K. Inorg. Chem. 48, 5392-5397 (2009).

  1. Lim, M. H.; Lau, I. H.; Barton, J. K. DNA Strand Cleavage Near a CC Mismatch Directed by a Metalloinsertor. Inorg. Chem. 46, 9528-9530 (2007).

  1. Lim, M. H.* Preparation of a Copper-Based Fluorescent Probe for Nitric Oxide and Its Use in Mammalian Cultured Cells. Nat. Protocols 2, 408-415 (2007).

  1. Lim, M. H.; Lippard, S. J. Metal-Based Turn-On Fluorescent Probes for Sensing Nitric Oxide. Acc. Chem. Res. 40, 41-51 (2007).

  1. Lim, M. H.; Wong, B. A.; Pitcock, W. H.; Mokshagundam, D.; Baik, M.-H.; Lippard, S. J. Direct Nitric Oxide Detection In Aqueous Solution by Copper(II) Fluorescein Complexes. J. Am. Chem. Soc. 128, 14364-14373 (2006).

  1. Lim, M. H.; Lippard, S. J. Fluorescent Nitric Oxide Detection by Copper Complexes Bearing Anthracenyl and Dansyl Fluorophore Ligands. Inorg. Chem. 45, 8980-8989 (2006).

  1. Lim, M. H.; Kuang, C.; Lippard, S. J. Nitric Oxide-Induced Fluorescence Enhancement by Displacement of Dansylated Ligands from Cobalt. ChemBioChem 7, 1571-1576 (2006).

  1. Lim, M. H.; Xu, D.; Lippard, S. J. Visualization of Nitric Oxide in Living Cells by a Copper-Based Fluorescent Probe. Nat. Chem. Bio. 2, 375-380 (2006).

  1. Oh, N. Y., Seo, M. S., Lim, M. H., Consugar, M. B., Park, M. J., Rohde, J.-U., Han, J., Kim, K. M., Kim, J., Que, L.Jr., Nam, W. Self-Hydroxylation of Perbenzoic Acids at a Nonheme Iron(II) Center. Chem. Commun. 5644-5646 (2005).

  1. Lim, M. H., Lippard, S. J. Copper Complexes for Fluorescence-Based NO Detection in Aqueous Solution. J. Am. Chem. Soc. 127, 12170-12171 (2005).

  1. Smith, R. C., Tennyson, A. G., Lim, M. H., Lippard, S. J. Conjugated Polymer-Based Fluorescence Turn-On Sensor for Nitric Oxide. Org. Lett. 7, 3573-3575 (2005).

  1. Hilderbrand, S. A., Lim, M. H., Lippard, S. J. Fluorescence-Based Nitric Oxide Detection. In Topics in Fluorescence Spectroscopy; C. D. Geddes, J. R. Lakowicz, Eds; Springer, Vol. 9, pp. 163-188 (2005).

  1. Woodroofe, C. C., Lim, M. H., Bu, W., Lippard, S. J. Synthesis of Isomerically Pure Carboxylate- and Sulfonate-Substituted Xanthene Fluorophores. Tetrahedron 61, 3097-3105 (2005).

  1. Park, S.-E., Song, W. J., Ryu, Y. O., Lim, M. H., Song, R., Kim, K. M., Nam, W. Parallel Mechanistic Studies on the Counterion Effect of Manganese Salen and Porphyrin Complexes on Olefin Epoxidation by Iodosylarenes. J. Inorg. Biochem. 99, 424-431 (2005).

  1. Lim, M. H., Lippard, S. J. Fluorescence-Based Nitric Oxide Detection by Ruthenium Porphyrin Fluorophore Complexes. Inorg. Chem. 43, 6366-6370 (2004).

  1. Rohde, J.-U., Torelli, S., Shan, X., Lim, M. H., Klinker, E. J., Kaizer, J., Chen, K., Nam, W., Que, L. Jr., Structural Insights into Nonheme Alkylperoxoiron(III) and Oxoiron(IV) Intermediates by X-ray Absorption Spectroscopy. J. Am. Chem. Soc. 126, 16750-16761 (2004).

  1. Hilderbrand, S. A., Lim, M. H., Lippard, S. J. Dirhodium Tetracarboxylate Scaffolds as Reversible Fluorescence-Based Nitric Oxide Sensors. J. Am. Chem. Soc. 126, 4972-4978 (2004).

  1. Nam, W., Park, S.-E., Lim, I. K., Lim, M. H., Hong, J., Kim, J. First Direct Evidence for Stereospecific Olefin Epoxidation and Alkane Hydroxylation by an Oxoiron(IV) Porphyrin Complex. J. Am. Chem. Soc. 125 14674-14675 (2003).

  1. Lim, M. H., Rohde, J.-U., Stubna, A., Bukowski, M. R., Costas, M., Ho, R. Y. N., Münck, E., Nam, W. Que, L. Jr. An FeIV=O Complex of a Tetradentate Tripodal Nonheme Ligand. Proc. Natl. Acad. Sci. U.S.A. 100, 3665-3670 (2003).

  1. Rohde, J.-U., In, J.-H., Lim, M. H., Brennessel, W. W., Bukowski, M. R., Stubna, A., Münck, E., Nam, W., Que, L. Jr. Crystallographic and Spectroscopic Characterization of a Nonheme Fe(IV)=O Complex. Science 299, 1037-1039 (2003).

  1. Nam, W., Choi, S. K., Lim, M. H., Rohde, J.-U., Kim, I., Kim, J., Kim, C., Que, L. Jr. Reversible Formation of Iodosylbenzene-Iron Porphyrin Intermediates in the Reaction of Oxoiron(IV) Porphyrin π-Cation Radicals and Iodobenzene. Angew. Chem. Int. Ed. 42, 109-111 (2003).

  1. Nam, W., Jin, S. W., Lim, M. H., Ryu, J. Y., Kim, C. Anionic Ligand Effect on the Nature of Epoxidizing Intermediates in Iron Porphyrin Complex-Catalyzed Epoxidation Reactions. Inorg. Chem. 14, 3647-3652 (2002).

  1. Nam, W., Kim, I., Lim, M. H., Choi, H. J., Lee, J., Jang, H. G. Isolation of an Oxomanganese(V) Porphyrin Intermediate in the Reaction of a Manganese(III) Porphyrin Complex and H2O2 in Aqueous Solution. Chemistry Eur. J. 8, 2067-2071 (2002).

  1. Kim, Y., Nam, W., Lim, M. H., Jin, S. W., Loungh, A. J., Kim, S.-J. Methoxy[meso-5,10,15,20-tetrakis(2,6-diflurorophenyl)porphyrinato]iron(III), [Fe(TDFPP)(OCH3)]. Acta Crystallogr. C57 556-557 (2001).

  1. Lim, M. H., Jin, S. W., Lee, Y. J., Jhon, G.-J., Nam, W., Kim, C. Electronic Effect of Iron(III) Porphyrin Complexes on the Epoxidation of Cyclohexene: Epoxidation versus Hydroxylation. Bull. Kor. Chem. Soc. 22, 93-96 (2001).

  1. Nam, W., Lim, M. H., Oh, S.-Y. Effect of Anionic Axial Ligands on the Formation of Oxoiron(IV) Porphyrin Intermediates. Inorg. Chem. 39, 5572-5575 (2000).

  1. Nam, W., Lim, M. H., Moon, S. K., Kim, C. Participation of Two Distinct Hydroxylating Intermediates in Iron(III) Porphyrin Complex-Catalyzed Hydroxylation of Alkanes. J. Am. Chem. Soc. 122, 10805-10809 (2000).

  1. Nam, W., Lim, M. H., Oh, S.-Y., Lee, J. H., Lee, H. J., Woo, S. K., Kim, C., Shin, W. Remarkable Anionic Axial Ligand Effects of Iron(III) Porphyrin Complexes on the Catalytic Oxygenations of Hydrocarbons by H2O2 and the Formation of Oxoiron(IV) Porphyrin Intermediates by m-Chloroperoxybenzoic Acid. Angew. Chem. Int. Ed. 39, 3646-3649 (2000).

  1. Nam, W., Oh, S.-Y., Lim, M. H., Choi, M.-H., Han, S.-Y., Jhon, G.-J. Temperature Effect on the Epoxidation of Olefins by Iron(III) Porphyrin Complex and tert-Alkyl Hydroperoxides. Chem. Commun. 1787-1788 (2000).

  1. Nam, W., Lim, M. H., Lee, H. J., Kim, C. Evidence for the Participation of Two Distinct Reactive Intermediates in Iron(III) Porphyrin Complex-Catalyzed Epoxidation Reactions. J. Am. Chem. Soc. 122, 6641-6647 (2000).

  1. Nam, W., Goh, Y. M., Lee, Y. J., Lim, M. H., Kim, C. Biomimetic Alkane Hydroxylations by an Iron(III) Porphyrin Complex with H2O2 and a High-Valent Iron(IV) Oxo Porphyrin Cation Radical Complex. Inorg. Chem. 38, 3238-3240 (1999).

  1. Lim, M. H., Lee, Y. J., Goh, Y. M., Nam, W., Kim, C. Hydroxylation of Aliphatic Hydrocarbons with m-Chloroperbenzoic Acid Catalyzed by Electron-Deficient Iron(III) Porphyrin Complexes. Bull. Chem. Soc. Jpn. 72, 707-713 (1999).

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