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Publications

Current Research

Moissiard, G., Cokus, S., Cary, J., Feng, S., Billi, A.C., Stroud, H., Husmann, D., Zhan, Y., Lajoie, B.R., McCrod, R.P., Hale, C.J., Feng, W., Michaels, S.D., Frand, A.R., Pellegrini, M., Dekker, J., Kim, J.K., and Jacobsen, S.  MORC family ATPases required for heterochromatin condensation and gene silencing. Science (in press).

Billi, A.C., Alessi, A.F., Khivansara, V., Han, T., Freeberg, M., Mitani, S., and Kim, J.K. The Caenorhabditis elegans HEN1 ortholog, HENN-1, methylates and stabilizes select subclasses of germline small RNAs.  PLoS Genetics 8: e1002617 (2012).

modENCODE Consortium (Gerstein, M.B. et al.,).  Integrative analysis of the Caenorhabditis elegans genome by the modENCODE Project.  Science 330: 1775-87 (2010).  

Mangone, M., Manoharan, A.P., Thierry-Mieg, D., Thierry-Mieg, J., Han, T., Mackowiak, S., Mis, E., Zegar, C., Gutwein, M.R., Khivansara, V., Salehi-Ashtiani, K., Harkins, T. Bouffard, P., Suzuki, Y., Sugano, S., Kohara, Y., Rajewsky, N., Piano, F., Gunsalus, K.C., and Kim, J.K.  The landscape of C. elegans 3’ UTRs.  Science 329: 432-5 (2010). PubMed Link

Irminger-Finger, I., Thomson, J.M., Kim, J.K. (editors).  MicroRNAs, a superimposed regulatory network for development and disease.  Int J Biochem Cell Biol 42: 1234-5 (2010).

Han, T., Manoharan, A.P., Harkins, T.T., Bouffard, P., Fitzpatrick, C., Chu, D.S., Thierry-Mieg, D., Thierry-Mieg, J., and Kim, J.K.  26G endo-siRNAs regulate spermatogenic and zygotic gene expression in C. elegans. Proc. Natl. Acad. Sci. USA 106:18674-9 (2009). PubMed Link

modENCODE Consortium.  Unlocking the secrets of the genome.  Nature 459: 927-30 (2009). PubMed Link

Friedländer, M.R., Adamidi, C., Han, T., Lebedeva, S., Isenbarger, T.A., Hirst, M., Marra, M., Nusbaum, C., Lee, W.L., Sánchez Alvarado, A., Kim, J.K., and Rajewsky, N. High-resolution discovery and profiling of planarian small RNAs. Proc. Natl. Acad. Sci. USA 106:11546-51 (2009). PubMed Link

Simon, D., Madison, J., Connery, A., Thompson-Peer, K., Soskis, M., Ruvkun, G., Kaplan, J., and Kim, J.K. The MicroRNA miR-1 Regulates a MEF-2-Dependent Retrograde Signal at Neuromuscular Junctions. Cell 133:903-915 (2008). PubMed Link

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Wang, D., Kennedy, S., Conte, D., Kim, J.K., Gabel, H.W., Kamath, R.S., Mello, C.C., and Ruvkun, G.  Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature 436: 593-597 (2005). PubMed Link

Kim, J.K., Gabel, H.W., Kamath, R.S., Tewari, M., Pasquinelli, A., Rual, J.F., Kennedy, S., Dybbs, M., Bertin, N., Kaplan, J.M., Vidal,M., and Ruvkun, G.  Functional genomic analysis of RNA interference in C.elegans. Science 308: 1164-1167 (2005).  PubMed Link

Kim, J., Krichevsky, A., Grad, Y., Hayes, G.D., Kosik, K.S., Church, G.M., and Ruvkun, G.  Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proc. Natl. Acad. Sci. USA 101: 360-365 (2004).   PubMed Link

Grad, Y., Aach, J., Hayes, G.D., Reinhart, B.J., Church, G.M., Ruvkun, G., and Kim, J.  Computational and experimental identification of C. elegans microRNAs. Molecular Cell 11: 1253-1263 (2003).  PubMed Link

 

Other Publications

Kim, J., Huang, W.P., Stromhaug, P.E., and Klionsky, D.J.  Convergence of multiple autophagy and cytoplasm-to-vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation. J. Biol. Chem. 277: 763-773 (2002). PubMed Link

Teter, S. A., Eggerton, K.P., Scott, S.V., Kim, J., Fischer, A.M., and Klionsky, D.J.  Degradation of lipid vesicles in the yeast vacuole requires function of Cvt17, a putative lipase. J. Biol. Chem. 276: 2083-2087 (2001). PubMed Link

Wang, C. W., Kim, J., Huang, W.P., Abeliovich, H., Stromhaug, P.E., Dunn, W.A., and Klionsky, D.J.  Apg2 is a novel protein required for the cytoplasm to vacuole targeting, autophagy, and pexophagy pathways. J. Biol. Chem. 276: 30442-30451 (2001). PubMed Link

Kim, J., Huang, W.P., and Klionsky, D.J. (2001). Membrane recruitment of Aut7p in the autophagy and cytoplasm-to-vacuole targeting pathways requires Aut1p, Aut2p, and the autophagy conjugation complex. J. Cell Biology 152: 51-64 (2001). PubMed Link

Kim, J., Kamada, Y., Stromhaug, P.E., Guan, J., Hefner-Gravink, A., Baba, M., Scott, S. V., Ohsumi, Y., Dunn, W. A., and Klionsky, D. J.  Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole. J. Cell Biology 153: 381-396 (2001). PubMed Link

Scott, S.V., Guan, J., Hutchins, M.U., Kim, J., and Klionsky, D.J.  Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway. Molecular Cell  7: 1131-1141 (2001). PubMed Link

Huang, W.P., Scott,S.V., Kim, J., and Klionsky, D.J.  The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways. J. Biol. Chem. 275: 5845-5851 (2000). PubMed Link

Noda, T., Kim, J., Huang, W.P., Baba, M., Tokunaga, C., Ohsumi, Y., & Klionsky, D.J. (2000). Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways. J. Cell Biology 148, 465-479. PubMed Link

Abeliovich, H., Dunn, W.A., Kim, J., and Klionsky, D.J. (2000). Dissection of autophagosome biogenesis into distinct nucleation and expansion steps. J. Cell Biology 151, 1025-1033. PubMed Link

Kim, J., and Klionsky, D.J. (2000). Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells. Annu. Rev. Biochem. 69, 303-342. PubMed Link

Kim, J., Scott, S.V., and Klionsky, D.J. (2000). Alternative protein sorting pathways. Int. Rev. Cytol. 198,153-201. PubMed Link

Kim, J., Dalton, V.M., Eggerton, K.P., Scott, S.V., and Klionsky, D.J. (1999). Apg7p/Cvt2p is required for the cytoplasm-to-vacuole targeting, macroautophagy, and peroxisome degradation pathways. Mol. Biol. Cell  10, 1337-1351. PubMed Link

Kim, J., Scott, S.V., Oda, M.N., and Klionsky, D.J. (1997). Transport of a large oligomeric protein by the cytoplasm to vacuole protein targeting pathway. J. Cell Biology 137, 609-618. PubMed Link

Kim, J., Alizadeh, P., Harding, T., Hefner-Gravink, A., and Klionsky, D.J. (1996). Disruption of the yeast ATH1 gene confers better survival after dehydration, freezing, and ethanol shock: Potential commercial applications. Appl. Environ. Microbiol. 62, 1563-1569. PubMed Link

Aanstoot, H.J., Kang, S.M., Kim, J., Lindsay, L.A., Roll, U., Knip, M., Atkinson, M., Mose-Larsen, P., Fey, S., Ludvigsson, J., Landin, M., Bruining, J., Maclaren, N., Akerblom, H.K., & Baekkeskov, S.(1996). Identification and characterization of glima 38, a glycosylated islet cell membrane antigen, which together with GAD(65) and IA2 marks the early phases of autoimmune response in type 1 diabetes. J. Clin. Invest. 97, 2772-2783.PubMed Link

Kim, J., Namchuk, M., Bugawan, T., Fu, Q., Jaffe, M., Shi, Y.G., Aanstoot, H.J., Turck, C.W., Erlich, H., Lennon, V., and Baekkeskov, S.(1994). Higher autoantibody levels and recognition of a linear NH2-terminal epitope in the autoantigen GAD(65) distinguish stiff man syndrome from insulin-dependent diabetes mellitus. J. Exp. Med. 180, 595-606.PubMed Link

Kim, J., Richter, W., Aanstoot, H.J., Shi, Y.G., Fu, Q., Rajotte, R., Warnock, G., and Baekkeskov, S. (1993). Differential expression of GAD(65) and GAD(67) in human, rat, and mouse pancreatic islets. Diabetes 42, 1799-1808. PubMed Link

 

Patents

Kim, J., Gabel, H., Kamath, R., and Ruvkun, G. (2005). Compositions and Methods that Modulate RNA Interference. Patent application filed. Serial No. 11/106,238.

Baekkeskov, S., Richter, W., Shi, Y., Namchuk, M., and Kim, J. (1997). Reagents and Methods for the Diagnosis and Treatment of Diabetes and Stiff Man Syndrome. United States Patent 5,691,448

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