Publications
Recent Articles | Articles (1999-2003) | Review Articles
Recent Articles
Ikenoue, T., Inoki, K., Zhao, B., Guan, K.L. (2008). PTEN acetylation modulates its interaction with PDZ domain. Cancer Res. 68(17), 6908-12. PubMed Link
Buller, C.L., Loberg, R.D., Fan, M.H., Zhu, Q., Park, J.L., Vesely, E., Inoki, K., Guan, K.L., Brosius, F.C. 3rd. (2008) A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression. Am J Physiol Cell Physiol. 295(3), C836-43. PubMed Link
Ikenoue, T., Inoki, K., Yang, Q., Zhou, X., Guan, K.L. (2008) Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling. EMBO J. 27(14), 1919-31. PubMed Link
Lee, C.H., Inoki, K., Karbowniczek, M., Petroulakis, E., Sonenberg, N., Henske, E.P., and Guan, K.L. (2007). Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J 26(23), 4812-23. PubMed Link
Inoki, K., Ouyang, H., Zhu, T., Lindvall, C., Wang, Y., Zhang, X., Yang, Q., Bennett, C., Harada, Y., Stankunas, K., Wang, CY., He, X., MacDougald, OA., You, M., Williams, BO., and Guan, K. L. (2006). TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126, 955-968. PubMed Link
Yang, Q., Inoki, K., Kim, E., and Guan, K. L. (2006). TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proc Natl Acad Sci USA 103, 6811- 6816. PubMed Link
Chong-Kopera, H., Inoki, K., Li, Y., Zhu, T., Garcia-Gonzalo, F. R., Rosa, J. L., and Guan, K. L. (2006). TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J Biol Chem 281, 8313-8316. PubMed Link
Yang, Q., Inoki, K., Ikenoue, T., and Guan, K. L. (2006). Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev 20, 2820-2832. PubMed Link
Guo, B., Inoki, K., Isono, M., Mori, H., Kanasaki, K., Sugimoto, T., Akiba, S., Sato, T., Yang, B., Kikkawa, R., et al. (2005). MAPK/AP-1-dependent regulation of PAI-1 gene expression by TGF-beta in rat mesangial cells. Kidney Int 68, 972-984. PubMed Link
Corradetti, M. N., Inoki, K., and Guan, K. L. (2005). The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem 280, 9769-9772. PubMed Link
Li, Y., Inoki, K., and Guan, K. L. (2004). Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mol Cell Biol 24, 7965-7975. PubMed Link
Corradetti, M. N., Inoki, K*., Bardeesy, N., DePinho, R. A., and Guan, K. L*. (2004). Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev 18, 1533-1538. (*co-corresponding) PubMed Link
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Articles (1999-2003)
Inoki, K., Zhu, T., and Guan, K. L. (2003). TSC2 mediates cellular energy response to control cell growth and survival. Cell 115, 577-590. PubMed Link
Inoki, K., Li, Y., Xu, T., and Guan, K. L. (2003). Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 17, 1829-1834. PubMed Link
Li, Y., Inoki, K., Vacratsis, P., and Guan, K. L. (2003). The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14-3-3. J Biol Chem 278, 13663-13671. PubMed Link
Li, Y., Inoki, K., Yeung, R., and Guan, K. L. (2002). Regulation of TSC2 by 14-3-3 binding. J Biol Chem 277, 44593-44596. PubMed Link
Inoki, K., Li, Y., Zhu, T., Wu, J., and Guan, K. L. (2002). TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 4, 648-657. PubMed Link
Nishio, T., Haneda, M., Koya, D., Inoki, K., Maeda, S., and Kikkawa, R. (2002). Cyclic AMP inhibits stretch-induced overexpression of fibronectin in glomerular mesangial cells. Eur J Pharmacol 437, 113-122. PubMed Link
Sawano, H., Haneda, M., Sugimoto, T., Inoki, K., Koya, D., and Kikkawa, R. (2002). 15-Deoxy-Delta12,14-prostaglandin J2 inhibits IL-1beta-induced cyclooxygenase-2 expression in mesangial cells. Kidney Int 61, 1957-1967. PubMed Link
Sugimoto, T., Haneda, M., Sawano, H., Isshiki, K., Maeda, S., Koya, D., Inoki, K., Yasuda, H., Kashiwagi, A., and Kikkawa, R. (2001). Endothelin-1 induces cyclooxygenase-2 expression via nuclear factor of activated T-cell transcription factor in glomerular mesangial cells. J Am Soc Nephrol 12, 1359-1368. PubMed Link
Inoki, K., Haneda, M., Ishida, T., Mori, H., Maeda, S., Koya, D., Sugimoto, T., and Kikkawa, R. (2000). Role of mitogen-activated protein kinases as downstream effectors of transforming growth factor-beta in mesangial cells. Kidney Int Suppl 77, S76-80. PubMed Link
Inoki, K., Haneda, M., Maeda, S., Koya, D., and Kikkawa, R. (1999). TGF-beta 1 stimulates glucose uptake by enhancing GLUT1 expression in mesangial cells. Kidney Int 55, 1704-1712. PubMed Link
Kohno, M., Yasunari, K., Minami, M., Kano, H., Maeda, K., Mandal, A. K., Inoki, K., Haneda, M., and Yoshikawa, J. (1999). Regulation of rat mesangial cell migration by platelet-derived growth factor, angiotensin II, and adrenomedullin. J Am Soc Nephrol 10, 2495-2502. PubMed Link
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Review Articles
Lee, C. H., Inoki, K., and Guan, K. L. (2007). mTOR pathway as a target in tissue hypertrophy. Annu Rev Pharmacol Toxicol 47, 443-467. PubMed Link
Inoki, K., and Guan, K. L. (2006). Complexity of the TOR signaling network. Inoki, K., and Guan, K. L. (2006). Complexity of the TOR signaling network. Trends Cell Biol 16, 206-212. PubMed Link
Inoki, K., Ouyang, H., Li, Y., and Guan, K. L. (2005). Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev 69, 79-100. PubMed Link
Li, Y., Inoki, K., Vikis, H., and Guan, K. L. (2005). Measurements of TSC2 GAP Activity Toward Rheb. Methods Enzymol 407, 46-54. PubMed Link
Inoki, K., Corradetti, M. N., and Guan, K. L. (2005). Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 37, 19-24. PubMed Link
Li, Y., Corradetti, M. N., Inoki, K., and Guan, K. L. (2004). TSC2: filling the GAP in the mTOR signaling pathway. Trends Biochem Sci 29, 32-38. PubMed Link
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