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Current research
Dumas, K.J., Delaney, C.E., Flibotte, S., Moerman, D.G., Csankovszki, G., and Hu, P.J. (2013). Unexpected role for dosage compensation in the control of dauer arrest, insulin-like signaling, and FoxO transcription factor activity in Caenorhabditis elegans. Genetics, in press.
Dumas, K.J., Guo, C.F., Shih, H.J., and Hu, P.J. (2013). The influence of steroid hormone signaling on life span control by C. elegans insulin-like signaling. G3: Genes, Genomes, Genetics, in press. Article PubMed link
Hu, P.J.*, Knoepp, S.M.*, Wu, R., and Cho, K.R. (2012). Ovarian steroid cell tumor with biallelic adenomatous polyposis coli inactivation in a patient with familial adenomatous polyposis. Genes, Chromosomes and Cancer 51:283-289. *equal contribution Article PubMed link
Alam, H., Williams, T.W., Dumas, K.J., Guo, C., Yoshina, S., Mitani, S., and Hu, P.J. (2010). EAK-7 controls development and lifespan by regulating nuclear DAF-16/FoxO activity. Cell Metabolism 12:30-41. Article PubMed link
Dumas, K.J., Guo, C.F., Wang, X., Burkhart, K.B., Adams, E.J., Alam, H., and Hu, P.J. (2010). Functional divergence of dafachronic acid pathways in the control of C. elegans development and lifespan. Developmental Biology 340:605-12. Article PubMed link
Hu, P.J. and Sherman, D.H. (2009). DANSing with Caenorhabditis elegans. Proceedings of the National Academy of Sciences USA 106:7685-6. Article PubMed link
Zhang, Y., Xu, J., Puscau, C., Kim, Y., Wang, X., Alam, H., and Hu, P.J. (2008). Caenorhabditis elegans EAK-3 inhibits dauer arrest via nonautonomous regulation of nuclear DAF-16/FoxO activity. Developmental Biology 315:290-302. Article PubMed link
Hu, P.J., Xu, J., and Ruvkun, G. (2006). Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling. PLoS Genetics 2(7), e99. Article PubMed link
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Previous research
Tewari, M.*, Hu, P.J.*, Ahn, J.S., Ayivi-Guedehoussou, N., Vidalain, P.O., Li, S.M., Milstein, S., Armstrong, C.M., Boxem, M., Butler, M.D., Busiguiina, S., Rual, J.F., Ibarrola, N., Chaklos, S.T., Bertin, N., Vaglio, P., Edgley, M.L., King, K.V., Albert, P.S., Vandenhaute, J., Pandey, A., Riddle, D.L., Ruvkun, G., & Vidal, M. (2004). Systematic interactome mapping and genetic perturbation analysis of a C. elegans TGF-beta signaling network. Molecular Cell 13:469-82. *equal contribution Article PubMed link
Hu, P.J., Shih, I.M., Hutchins, G.M., & Hellmann, D.B. (1997). Polyarteritis nodosa of the pericardium: antemortem diagnosis in a pericardiectomy specimen. Journal of Rheumatology 24:2042-44. PubMed link
Logan, S.K., Falasca, M., Hu, P., & Schlessinger, J. (1997). Phosphatidylinositol 3-kinase mediates epidermal growth factor-induced activation of the c-Jun N-terminal kinase signaling pathway. Molecular and Cellular Biology 17:5784-90. PubMed link
Spivak-Kroizman, T., Mohammadi, M., Hu, P., Jaye, M., Schlessinger, J., & Lax, I. (1994). Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells. Journal of Biological Chemistry 269:14419-23. PubMed link
Hu, P., & Schlessinger, J. (1994). Direct association of p110β phosphatidylinositol 3-kinase with p85 is mediated by an N-terminal fragment of p110β. Molecular and Cellular Biology 14:2577-83. PubMed link
Piccione, E., Case, R.D., Domchek, S.M., Hu, P., Chaudhuri, M., Backer, J.M., Schlessinger, J., & Shoelson, S.E. (1993). Phosphatidylinositol 3-kinase p85 SH2 domain specificity defined by direct phosphopeptide SH2 domain binding. Biochemistry 32:3197-3202. PubMed link
Shoelson, S.E., Sivaraja, M., Williams, K.P., Hu, P., Schlessinger, J., & Weiss, M.A. (1993). Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation. EMBO Journal 12:795-802. PubMed link
Felder, S., Zhou, M., Hu, P., Urena, J., Ullrich, A., Chaudhuri, M., White, M., Shoelson, S.E., & Schlessinger, J. (1993). SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange. Molecular and Cellular Biology 13:1449-55. PubMed link
Hu, P., Mondino, A., Skolnik, E.Y., & Schlessinger, J. (1993). Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85. Molecular and Cellular Biology 13:7677-88. PubMed link
Backer, J.M., Myers, M.G., Shoelson, S.E., Chin, D.J., Sun, X.J., Mirapeix, M., Hu, P., Margolis, B., Skolnik, E.Y., Schlessinger, J., & White, M.F. (1992). Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation. EMBO Journal 11:3469-79. PubMed link
Hu, P., Margolis, B., Skolnik, E.Y., Lammers, R., Ullrich, A., & Schlessinger, J. (1992). Interaction of phosphatidylinositol 3-kinase associated p85 with epidermal growth factor and platelet-derived growth factor receptors. Molecular and Cellular Biology 12:981-90. PubMed link
Li, W., Hu, P., Skolnik, E.Y., Ullrich, A., & Schlessinger, J. (1992). The SH2 and SH3 domain containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors. Molecular and Cellular Biology 12:5824-33. PubMed link
Margolis, B.*, Hu, P.*, Katzav, S., Li, W., Oliver, J.M., Ullrich, A., Weiss, A., & Schlessinger, J. (1992). Tyrosine phosphorylation of vav proto-oncogene product containing SH2 domain and transcription factor motifs. Nature 356:71-4. *equal contribution PubMed link
Myers, M.G., Backer, J.M., Sun, X.J., Shoelson, S., Hu, P., Schlessinger, J., Yoakim, M., Schaffhausen, B., & White, M.F. (1992). IRS-1 activates phosphatidylinositol 3'-kinase by associating with src homology 2 domains of p85. Proceedings of the National Academy of Sciences of the USA 89:10350-54. PubMed link
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Reviews
Murphy, C.T. and Hu, P.J. (2013). Insulin/insulin-like growth factor signaling in C. elegans (March 28, 2013), WormBook, ed. The C. elegans Research Community, in press.
Williams, T.W., Dumas, K.J., and Hu, P.J. (2010). EAK proteins: novel conserved regulators of C. elegans lifespan. Aging (Albany NY) 2:742-7. Article PubMed link
Hu, P.J. Dauer (August 08, 2007), WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.144.1, Article PubMed link
Hu, P., Margolis, B., & Schlessinger, J. (1993). Vav - a potential link between tyrosine kinases and Ras-like GTPases in hematopoietic cell signaling. Bioessays 15:179-83. PubMed link
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