Gestwicki Publications

University of Michigan | Editorial Material |Prior Work |

University of Michigan

(42) Damm, K. L., Quintero, J. J., Gestwicki, J. E., & Carlson, H. A. (2008) Clarifying allosteric control of flap conformations in HIV-1 protease. Proteins, (in press).

(41) Geda, P., Patury, S., Ma, J., Barucha, N., Dobry, C. J., Lawson, S. K., Gestwicki, J. E. & Kumar, A. (2008) A small molecule-directed approach to control protein localization and function. Yeast (in press).

(40) Gestwicki, J. E. & Kumar, A. (2008) Two- and three-hybrid systems. Encyclopedia of Chemical Biology (in press).

(39) Marinec, P. S., Lancia, J. K. & Gestwicki, J. E. (2008) Bifunctional molecules evade cytochrome P450 metabolism by forming protective complexes with FK506-binding protein" Molecular Biosystems 4:571-578. PubMed Link

(38) Damm, K. L., Ung, P. M., Quintero, J. J., Gestwicki, J. E. & Carlson, H. A. (2008) A poke in the eye: inhibiting HIV-1 protease through its flap-recognition pocket. Biopolymers 89:643-652. PubMed Link

(37) Wisén, S. & Gestwicki, J. E. (2008) Identification of small molecules that modify the protein folding activity of heat shock protein 70 (Hsp70) Analytical Biochemistry 374:371-377. PubMed Link

(36) Wisén, S., Androsavich, J., Evans, C. G., Chang, L. & Gestwicki, J. E. (2008) Chemical modifiers of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase Bioorganic & Medicinal Chemistry Letters 18:60-65. PubMed Link

(35) Chang, L., Bertelsen, E. B., Wisén, S., Larsen, E. M., Zuiderweg, E. R. P., & Gestwicki, J. E. (2008) High throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone, DnaK. Analytical Biochemistry 372(2):167-176. PubMedLink

(34) Hadden, M. K., Galam, L. Gestwicki, J. E., Matts, R. L. & Blagg, B. S. J. (2007) Derrubone, an inhibitor of the Hsp90 protein folding machinery Journal of Natural Products 70(12):2014-2018. PubMed Link

(33) Gestwicki, J. E. & Marinec, P. S. (2007) Chemical control over protein-protein interactions: Beyond inhibitors. Combinatorial Chemistry & High Throughput Screening 10(8):667-675. PubMed Link

(32) Reinke, A. A. & Gestwicki, J. E. (2007) Structure activity relationships for amyloid beta aggregation inhibitors based on curcumin: Influence of linker length and flexibility. Chemical Biology & Drug Design, 70, 206-215. PubMed Link

(31) Stankunas, K., Bayle, J. H., Havranek, J. J., Wandless, T. J., Baker, D., Crabtree, G. R., & Gestwicki, J. E. (2007) Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands. ChemBioChem, 8, 1162-1169. PubMed Link

(30) Rubinsztein, D. C., Gestwicki, J. E., Murphy, L. O., & Klionsky, D. J. (2007). Potential therapeutic applications of autophagy. Nature Rev. Drug Discovery, 6, 304-312. PubMed Link

(29) Evans, C. G., Wisén, S., & Gestwicki, J. E. (2006) Heat shock proteins 70 and 90 inhibit early stages of amyloid beta (1-42) aggregation in vitro. Journal of Biological Chemistry, 281, 33182-33191. PubMed Link

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Editorial Material

Gestwicki, J. E. (2008) The interface of chemistry and biology is actually a continuum (Meeting Report). ACS Chemical Biology 3:328-334.

Gestwicki, J. E. (2006) Reclamation of proteins from the cellular scrap heap. ACS Chemical Biology, 1, 201-203. PubMed Link

Gestwicki, J. E. (2005). Target identification for a promising anti-lupus drug. Chemistry & Biology, 12, 414-415. PubMed Link

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Prior Work

(28) Liu, K., Gestwicki, J. E., Crabtree, G. R. (2006) Bringing small molecule regulation of protein activity to developmental systems. Analysis of Growth Factor Signaling in Embryos, Whitman, M. and Sater, A. Eds., CRC Press, 369-393.

(27) Bayle, J. H., Grimley, J. S., Stankunas, K., Gestwicki, J. E., Wandless, T. J., & Crabtree, G. R. (2006). Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. Chemistry & Biology, 13, 99-107. PubMed Link

(26) Kiessling, L. L., Gestwicki, J. E., & Strong, L. E. (2006). Synthetic multivalent ligands as probes of signal transduction. Angew. Chem., 45, 2348-2368. PubMed Link

(25) Bose, M., Gestwicki, J. E., Devasthali, V., Crabtree, G. R., & Graef, I. A. (2005). "Nature inspired" drug-protein complexes as inhibitors of A-beta aggregation. Biochemical Society Transactions, 33, 543-547. PubMed Link

(24) Chang, C. P., Neilson, J. R., Bayle, J. H., Gestwicki, J. E., Kuo, A., Stankunas, K., Graef, I. A., & Crabtree, G. R. (2004). A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell, 118, 649-663. PubMed Link

(23) Gestwicki, J. E., Crabtree, G. R., & Graef, I. A. (2004). Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation. Science, 306, 865-869. PubMed Link

(22) Stankunas, K., Bayle, J. H., Gestwicki, J. E., Lin, Y. M., Wandless, T. J., & Crabtree, G. R. (2003). Conditional protein alleles using knockin mice and a chemical inducer of dimerization. Molecular Cell, 12, 1615-1624. PubMed Link

(21) Gestwicki, J. E., Cairo, C. W., Borrok, M. J., & Kiessling, L. L. (2003). Visualization and characterization of receptor clusters by transmission electron microscopy. Methods in Enzymology, 362, 301-312. PubMed Link

(20) Gestwicki, J. E., Cairo, C. W., Mann, D. A., Owen, R. M., & Kiessling, L. L. (2002). Selective immobilization of multivalent ligands for surface plasmon resonance and fluorescence microscopy. Analytical Biochemistry, 305, 149-155. PubMed Link

(19) Gestwicki, J. E., Strong, L. E., Cairo, C. W., Boehm, F. J., & Kiessling, L. L. (2002). Cell aggregation by scaffolded receptor clusters. Chemistry & Biology, 9, 163-169. PubMed Link

(18) Lamanna, A. C., Gestwicki, J. E., Strong, L. E., Borchardt, S. L., Owen, R. M., & Kiessling, L. L. (2002). Conserved amplification of chemotactic responses through chemoreceptor interactions. Journal of Bacteriology, 184, 4981-4987. PubMed Link

(17) Cairo, C. W., Gestwicki, J. E., Kanai, M., & Kiessling, L. L. (2002). Control of multivalent interactions by binding epitope density. Journal of the American Chemical Society, 124, 1615-1619. PubMed Link

(16) Gestwicki, J. E., Cairo, C. W., Strong, L. E., Oetjen, K. A., & Kiessling, L. L. (2002). Influencing receptor-ligand binding mechanisms with multivalent ligand architecture. Journal of the American Chemical Society, 124, 14922-14933. PubMed Link

(15) Gestwicki, J. E., & Kiessling, L. L. (2002). Inter-receptor communication through arrays of bacterial chemoreceptors. Nature, 415, 81-84. PubMed Link

(14) Owen, R. M., Gestwicki, J. E., Young, T., & Kiessling, L. L. (2002). Synthesis and applications of end-labeled neoglycopolymers. Organic Letters, 4, 2293-2296. PubMed Link

(13) Gestwicki, J. E., Hsieh, H. V., & Pitner, J. B. (2001). Using receptor conformational change to detect low molecular weight analytes by surface plasmon resonance. Analytical Chemistry, 73, 5732-5737. PubMed Link

(12) Gestwicki, J. E., Strong, L. E., Borchardt, S. L., Cairo, C. W., Schnoes, A. M., & Kiessling, L. L. (2001). Designed potent multivalent chemoattractants for Escherichia coli. Bioorganic & Medicinal Chemistry, 9, 2387-2393. PubMed Link

(11) Gestwicki, J. E., Strong L. E., & Kiessling, L. L. (2000). Visualization of single multivalent receptor-ligand complexes by transmission electron microscopy. Angewandte Chemie - International Edition, 39, 4567-4570. PubMed Link

(9) Gordon, E. J., Gestwicki, J. E., Strong, L. E., & Kiessling, L. L. (2000). Synthesis of end-labeled multivalent ligands for exploring cell-surface-receptor-ligand interactions. Chemistry & Biology, 7, 9-16. PubMed Link

(8) Gestwicki, J. E., Strong, L. E., & Kiessling, L. L. (2000). Tuning chemotactic responses with synthetic multivalent ligands. Chemistry & Biology, 7, 583-591. PubMed Link

(7) Maki, N., Gestwicki, J. E., Lake, E. M., Kiessling, L. L., & Adler, J. (2000). Motility and chemotaxis of filamentous cells of Escherichia coli. Journal of Bacteriology, 182, 4337-4342. PubMed Link

(6) Gestwicki, J. E., Lamanna, A. C., Harshey, R. M., McCarter, L. L., Kiessling, L. L., & Adler, J. (2000). Evolutionary conservation of methyl-accepting chemotaxis protein location in Bacteria and Archaea. Journal of Bacteriology, 182, 6499-6502. PubMed Link

(5) Kiessling, L. L., Gestwicki, J. E., & Strong, L. E. (2000). Synthetic multivalent ligands in the exploration of cell-surface interactions. Current Opinion in Chemical Biology,
4, 696-703. PubMed Link

(4) Kiessling, L. L., Strong, L. E., & Gestwicki, J. E. (2000). Principles for multivalent ligand design. Annual Reports in Medicinal Chemistry, 35, 321-330.

(3) Kabza, K., Gestwicki, J. E., & McGrath, J. L. (2000). Contact angle goniometry as a tool for surface tension measurements of solids, using Zisman plot method - A physical chemistry experiment. Journal of Chemical Education, 77, 63-65.

(2) Kabza, K. G., Chapados, B. R., Gestwicki, J. E., & McGrath, J. L. (2000). Microwave-induced esterification using heterogeneous acid catalyst in a low dielectric constant medium. Journal of Organic Chemistry, 65, 1210-1214. PubMed Link

(1) Kabza, K. G., Gestwicki, J. E., McGrath, J. L., & Petrassi, H. M. (1996). Effect of microwave radiation on copper(II) 2,2'-bipyridyl-mediated hydrolysis of bis(p-nitrophenyl) phosphodiester and enzymatic hydrolysis of carbohydrates. Journal of Organic Chemistry, 61, 9599-9602.

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