University of Michigan | Editorial Material | Prior Work |
2012
(75) Congdon, E. E., Wu, J. W., Myeku, Figueroa, Y. H., Herman, M., Marinec, P. S., Gestwicki, J. E., Dickey, C. A., Yu, W. H., Duff, K. (2012) "Phenothiazine induces autophagy and attenuates tauopathy in vitro and in vivo” Autophagy (in press).
(74) Thompson, A. D., Bernard, S. M., Skiniotis, G., Gestwicki, J. E. (2012) “Visualization and functional analysis of the oligomeric states of Escherichia coli heat shock protein 70 (Hsp70/DnaK)” Cell Stress Chaperones (in press).
(73) Zuiderweg, E. R. P., Bertelsen, E. B., Rousaki, A., Mayer, M. P., Gestwicki, J. E., Ahmad, A. (2012) “Allostery in the Hsp70 chaperone proteins” Topics Curr. Chem. (in press).
(72) Gestwicki, J. E. and Garza, D. “Protein quality control in neurodegenerative disease” in The Molecular Biology of Neurodegenerative Disease. D. B. Teplow, Ed. Academic Press Inc. 2012, Progress in Molecular Biology and Translational Science, vol. 101.
2011
(71) Walter, G. M., Smith, M. C., Wisen, S., Basrur, V., Elenitoba-Johnson, K. S. J., Duennwald, M. L., Kumar, A., Gestwicki, J. E. (2011) “Ordered assembly of heat shock proteins, Hsp26, Hsp70, Hsp90 and Hsp104, on expanded polyglutamine fragments revealed by chemical probes” J. Biol. Chem. 286:40486-40493. PubMed Link
(70) Scaglione, K. M., Zavodszky, E., Todi, S. V., Patury, S., Xu, P., Rodriguez-Lebron, E., Fischer, S., Djarmata, A., Peng, J., Gestwicki, J. E., Paulson, H. L. (2011) “Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP” Molecular Cell 43:599-612. PubMed Link
(69) Morishima, Y., Miranda, L., Peng, H-M., Miyata, Y., Gestwicki, J. E., Pratt, W., Osawa, Y. (2011) “Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft” Biochemistry 50:7146-7156. PubMed Link
(68) Rousaki, K., Miyata, Y., Jinwal, U. K., Dickey, C. A., Gestwicki, J. E., Zuiderweg, E. R. P. (2011) “Allosteric drugs: the interaction of anti-tumor compound MKT-077 with human Hsc70 chaperones” J. Mol. Biol. 411:614-632. PubMed Link
(67) Miyata, Y., Koren III, J., Kiray, J., Dickey, C. A., Gestwicki, J. E. (2011) “Molecular chaperones and regulation of tau quality control: Strategies for drug discovery in tauopathies” Future Med. Chem. 3:1523-1537. PubMed Link
(66) Reinke, A. A. and Gestwicki, J. E. (2011) “Insights into amyloid structure using chemical probes” Chemical Biology & Drug Design 77:399-411. PubMed Link
(65) Evans, C. G., Smith, M. C., Carolan, J. P., Gestwicki, J. E. (2011) “Improved synthesis of 15-deoxyspergualin analogs using the Ugi multicomponent reaction” Bioorgan. Med. Chem. Lett. 21:2587-2590. PubMed Link
(64) Chang, L., Miyata, Y., Ung, P. M. U., Bertelsen, E. B., McQuade, T. J., Carlson, H. A., Zuiderweg, E. R. P., Gestwicki, J. E. (2011) “Chemical screens against a reconsitituted multi-protein complex: myricetin blocks DnaJ regulation of DnaK through an allosteric mechanism” Chemistry & Biology 18:210-221. PubMed Link
(63) Bainor, A., Chang, L., McQuade, T. J., Webb, B., Gestwicki, J. E. (2011) “Bicinchoninic acid (BCA) assay in low volume” Analytical Biochem. 410:310-312. PubMed Link
(62) Evans, C. G., Jinwal, U. K., Makley, L. N., Dickey, C. A., Gestwicki, J. E. (2011) “Identification of dihydropyridines that reduce cellular tau levels" Chem. Commun. 47:529-531. PubMed Link
2010
(61) Reinke, A. A., Ung, P. M.-U., Quintero, J. J., Carlson, H. A., Gestwicki, J. E. (2010) “Chemical probes selectively recognize the earliest Aβ oligomers in complex mixtures” J. Am. Chem. Soc. 132:17655-17657. PubMed Link
(60) O’Leary III, J. C., Li, Q., Marinec, P. S., Blair, L. J., Congdon, E. E., Johnson, A. G., Jinwal, U. K., Koren III, J., Jones, J. R., Kraft, C., Peters, M., Abisambra, J. F., Duff, K. E., Weeber, E. J., Gestwicki, J. E., Dickey, C. A. (2010) “Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden” Molecular Neurodegeneration 5:45. PubMed Link
(59) Xu, T., Johnson, C. A., Gestwicki, J. E., Kumar, A. (2010) "Conditionally controlling nuclear trafficking in yeast by chemical-induced protein dimerization" Nature Protocols 5(11):1831-1843. PubMed Link
(58) Reinke, A. A., Abulwerdi, G. A., Gestwicki J. E. (2010) "Quantifying pre-fibrillar amyloids using a 'thioflavin-like' spectroscopic method" ChemBioChem 11:1889-1895. PubMed Link
(57) Miyata, Y., Chang, L., Bainor, A., McQuade, T. J., Walczak, C. P., Zhang, Y., Larsen, M. J., Kirchoff, P., Gestwicki, J. E. (2010) “High throughput screen for Escherichia coli heat shock protein 70 (Hsp70/DnaK): colorimetric ATPase assay in low volume by exploiting energy transfer” J. Biomolecular Screening 15:1211-1219. PubMed Link
(56) Wisén, S., Bertelsen, E. B., Thompson, A. D., Patury, S., Ung, P., Chang, L., Evans, C. G., Walter, G. M., Wipf, P., Carlson, H. A., Brodsky, J. L., Zuiderweg, E. R. P., Gestwicki, J. E. (2010) "Binding of a small molecule at a protein-protein interface regulates chaperone activity in the Hsp70-Hsp40 complex" ACS Chemical Biology 5:611-622. PubMed Link
(55) Chang, L., Thompson, A. D., Ung, P., Carlson, H. A., Gestwicki, J. E. (2010) "Mutagenesis reveals the complex relationships between ATPase rate and the chaperone activities of Escherichia coli heat shock protein 70 (Hsp70/DnaK)" J. Biol. Chem. 285:21282-21291. PubMed Link
(54) Wang, A. M., Morishima, Y., Clapp, K. M., Peng, H.-M., Pratt, W. B., Gestwicki, J. E., Osawa, Y., Lieberman, A. P. (2010) "Inhibition of Hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation" J. Biol. Chem. 285:15714-15723. PubMed Link.
(53) Evans, C. G., Chang, L., Gestwicki, J. E. (2010) "Heat shock protein 70 (Hsp70) as an emerging drug target" J. Med. Chem. 53:4585-4602. PubMed Link
(52) Jinwal, U. K., O'Leary III, J. C., Borysov, S., Jones, J. R., Li, Q., Koren III, J., Abisambra, J. F., Vestal, G. D., Lawson, L. Y., Johnson, A. G., Blair, L. J., Yin, Y., Miyata, Y., Gestwicki, J. E., Dickey, C. A. (2010) "Hsc70 rapidly engages tau after microtubule destablization" J. Biol. Chem. 285:16798-16805. PubMed Link
(51) Koren III, J., Jinwal, U. K., Jin, Y, O'Leary, J., Jones, J. R., Johnson, A. G., Blair, L. J., Abisambra, J. F., Chang, L., Miyata, Y., Cheng, A. M., Guo, J., Cheng, J. Q., Gestwicki, J. E., Dickey, C. A. (2010) "Facilitating Akt clearance via manipulation of Hsp70 activity and levels" J. Biol. Chem. 285:2498-2505. PubMed Link
2009
(50) Patury, S., Miyata, Y., Gestwicki, J. E. (2009) "Pharmacological targeting of the Hsp70 chaperone" Current Topics Med. Chem. 9(15):1336-1351. PubMedLink
(49) Jinwal, R. U. K, Miyata, Y., Koren, J., Jones, J. R., Trotter, J. H., Weeber, E. J., Chang, L., Shults, C. L., Rousaki, A. Zuiderweg, E. R. P., Gestwicki, J. E., Dickey, C. A. (2009) Chemical manipulation of Hsp70 ATPase activity regulates tau stability. J. Neurosci., 29:12079-12088. PubMedLink
(48) Reinke, A. A., Seh, H. Y., Gestwicki, J. E. (2009) "A chemical screen approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta" Bioorgan. & Med. Chem. Lett., 19:4952-4957. PubMedLink
(47) Marinec, P. S., Evans, C. G., Gibbons, G. S., Tarnowski, M. A., Overbeek, D. L. Gestwicki, J. E. (2009) Synthesis of orthogonally reactive FK506 derivatives via olefin cross metathesis. Bioorganic & Medicinal Chemistry, 17:5763 5768. PubMedLink
(46) Evans, C. G. and Gestwicki, J. E. (2009) Enantioselective organocatalytic Hantzsch synthesis of polyhydroquinolines. Organic Letters, 11:2957-2959. PubMed Link
(45) Bertelsen, E. B., Chang, L., Gestwicki, J. E., Zuiderweg, E. R. P. (2009) Solution conformation of wild-type E. coli Hsp70 (DnaK) chaperone complexes with ADP and substrate. Proc. Nat. Acad. Sci. USA,106:8471-8476. PubMed Link
(44) Patury, S., Geda, P., Dobry, C. J., Kumar, A., Gestwicki, J.E. (2009) Conditional nuclear import and export of yeast proteins using a chemical inducer of dimerization. Cellular Biochemistry & Biophysics, 53:127-134. PubMedLink
(43) Marinec, P. S., Chen, L., Barr, K. J., Mutz, M. W., Crabtree, G. R., Gestwicki, J. E. (2009) FK506-binding protein partitions a modified HIV protease inhibitor into blood cells and prolongs its lifetime in vivo. Proc. Nat. Acad. Sci. USA, 106(5):1336-1341. PubMed Link
(42) Lexa, K. W., Damm, K. L., Quintero, J. J., Gestwicki, J. E., & Carlson, H. A. (2009) Clarifying allosteric control of flap conformations in HIV-1 protease. Proteins, 74:872-880. PubMed Link
2008
(41) Geda, P., Patury, S., Ma, J., Barucha, N., Dobry, C. J., Lawson, S. K., Gestwicki, J. E. & Kumar, A. (2008) A small molecule-directed approach to control protein localization and function. Yeast, 25:577-594. PubMed Link
(40) Gestwicki, J. E. & Kumar, A. (2008) Two- and three-hybrid systems. Encyclopedia of Chemical Biology, p. 615-629.
(39) Marinec, P. S., Lancia, J. K. & Gestwicki, J. E. (2008) Bifunctional molecules evade cytochrome P450 metabolism by forming protective complexes with FK506-binding protein. Molecular Biosystems, 4:571-578. PubMed Link
(38) Damm, K. L., Ung, P. M., Quintero, J. J., Gestwicki, J. E. & Carlson, H. A. (2008) A poke in the eye: inhibiting HIV-1 protease through its flap-recognition pocket. Biopolymers, 89:643-652. PubMed Link
(37) Wisén, S. & Gestwicki, J. E. (2008) Identification of small molecules that modify the protein folding activity of heat shock protein 70 (Hsp70). Analytical Biochemistry, 374:371-377. PubMed Link
(36) Wisén, S., Androsavich, J., Evans, C. G., Chang, L. & Gestwicki, J. E. (2008) Chemical modifiers of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase. Bioorganic & Medicinal Chemistry Letters, 18:60-65. PubMed Link
(35) Chang, L., Bertelsen, E. B., Wisén, S., Larsen, E. M., Zuiderweg, E. R. P., & Gestwicki, J. E. (2008) High throughput screen for small molecules that modulate the ATPase activity of the molecular chaperone, DnaK. Analytical Biochemistry, 372(2):167-176. PubMedLink
2007
(34) Hadden, M. K., Galam, L. Gestwicki, J. E., Matts, R. L. & Blagg, B. S. J. (2007) Derrubone, an inhibitor of the Hsp90 protein folding machinery. Journal of Natural Products,70(12):2014-2018. PubMed Link
(33) Gestwicki, J. E. & Marinec, P. S. (2007) Chemical control over protein-protein interactions: Beyond inhibitors. Combinatorial Chemistry & High Throughput Screening, 10(8):667-675. PubMed Link
(32) Reinke, A. A. & Gestwicki, J. E. (2007) Structure activity relationships for amyloid beta aggregation inhibitors based on curcumin: Influence of linker length and flexibility. Chemical Biology & Drug Design, 70:206-215. PubMed Link
(31) Stankunas, K., Bayle, J. H., Havranek, J. J., Wandless, T. J., Baker, D., Crabtree, G. R., & Gestwicki, J. E. (2007) Rescue of degradation-prone mutants of the FK506-rapamycin binding (FRB) protein with chemical ligands. ChemBioChem, 8:1162-1169. PubMed Link
(30) Rubinsztein, D. C., Gestwicki, J. E., Murphy, L. O., & Klionsky, D. J. (2007) Potential therapeutic applications of autophagy. Nature Rev. Drug Discovery, 6:304-312. PubMed Link
2006
(29) Evans, C. G., Wisén, S., & Gestwicki, J. E. (2006) Heat shock proteins 70 and 90 inhibit early stages of amyloid beta (1-42) aggregation in vitro. Journal of Biological Chemistry, 281:33182-33191. PubMed Link
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Gestwicki, J. E. (2009) “Special Series: Molecular Chaperones in Protein Folding and Disease (Editorial)” Biopolymers (in press).
Gestwicki, J. E. (2009) “Chemical biology: Learning through case studies (Book Review)” ChemBioChem 10:2539-2541.
Gestwicki, J. E. (2008) "The interface of chemistry and biology is actually a continuum (Meeting Report)" ACS Chemical Biology 3:328-334. PubMed Link
Gestwicki, J. E. (2006) "Reclamation of proteins from the cellular scrap heap (News and Views" ACS Chemical Biology, 1:201-203. PubMed Link
Gestwicki, J. E. (2005) "Target identification for a promising anti-lupus drug (News and Views)". Chemistry & Biology, 12:414-415. PubMed Link
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(28) Liu, K., Gestwicki, J. E., Crabtree, G. R. (2006) Bringing small molecule regulation of protein activity to developmental systems. Analysis of Growth Factor Signaling in Embryos, Whitman, M. and Sater, A. Eds., CRC Press, 369-393.
(27) Bayle, J. H., Grimley, J. S., Stankunas, K., Gestwicki, J. E., Wandless, T. J., & Crabtree, G. R. (2006). Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity. Chemistry & Biology, 13: 99-107. PubMed Link
(26) Kiessling, L. L., Gestwicki, J. E., & Strong, L. E. (2006). Synthetic multivalent ligands as probes of signal transduction. Angewandte Chemie, 45:2348-2368. PubMed Link
(25) Bose, M., Gestwicki, J. E., Devasthali, V., Crabtree, G. R., & Graef, I. A. (2005). "Nature inspired" drug-protein complexes as inhibitors of A-beta aggregation. Biochemical Society Transactions, 33:543-547. PubMed Link
(24) Chang, C. P., Neilson, J. R., Bayle, J. H., Gestwicki, J. E., Kuo, A., Stankunas, K., Graef, I. A., & Crabtree, G. R. (2004). A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell, 118:649-663. PubMed Link
(23) Gestwicki, J. E., Crabtree, G. R., & Graef, I. A. (2004). Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation. Science, 306:865-869. PubMed Link
(22) Stankunas, K., Bayle, J. H., Gestwicki, J. E., Lin, Y. M., Wandless, T. J., & Crabtree, G. R. (2003). Conditional protein alleles using knockin mice and a chemical inducer of dimerization. Molecular Cell, 12:1615-1624. PubMed Link
(21) Gestwicki, J. E., Cairo, C. W., Borrok, M. J., & Kiessling, L. L. (2003). Visualization and characterization of receptor clusters by transmission electron microscopy. Methods in Enzymology, 362:301-312. PubMed Link
(20) Gestwicki, J. E., Cairo, C. W., Mann, D. A., Owen, R. M., & Kiessling, L. L. (2002). Selective immobilization of multivalent ligands for surface plasmon resonance and fluorescence microscopy. Analytical Biochemistry, 305:149-155. PubMed Link
(19) Gestwicki, J. E., Strong, L. E., Cairo, C. W., Boehm, F. J., & Kiessling, L. L. (2002). Cell aggregation by scaffolded receptor clusters. Chemistry & Biology, 9:163-169. PubMed Link
(18) Lamanna, A. C., Gestwicki, J. E., Strong, L. E., Borchardt, S. L., Owen, R. M., & Kiessling, L. L. (2002). Conserved amplification of chemotactic responses through chemoreceptor interactions. Journal of Bacteriology, 184:4981-4987. PubMed Link
(17) Cairo, C. W., Gestwicki, J. E., Kanai, M., & Kiessling, L. L. (2002). Control of multivalent interactions by binding epitope density. Journal of the American Chemical Society, 124:1615-1619. PubMed Link
(16) Gestwicki, J. E., Cairo, C. W., Strong, L. E., Oetjen, K. A., & Kiessling, L. L. (2002). Influencing receptor-ligand binding mechanisms with multivalent ligand architecture. Journal of the American Chemical Society, 124:14922-14933. PubMed Link
(15) Gestwicki, J. E., & Kiessling, L. L. (2002). Inter-receptor communication through arrays of bacterial chemoreceptors. Nature, 415:81-84. PubMed Link
(14) Owen, R. M., Gestwicki, J. E., Young, T., & Kiessling, L. L. (2002). Synthesis and applications of end-labeled neoglycopolymers. Organic Letters, 4:2293-2296. PubMed Link
(13) Gestwicki, J. E., Hsieh, H. V., & Pitner, J. B. (2001). Using receptor conformational change to detect low molecular weight analytes by surface plasmon resonance. Analytical Chemistry, 73:5732-5737. PubMed Link
(12) Gestwicki, J. E., Strong, L. E., Borchardt, S. L., Cairo, C. W., Schnoes, A. M., & Kiessling, L. L. (2001). Designed potent multivalent chemoattractants for Escherichia coli. Bioorganic & Medicinal Chemistry, 9:2387-2393. PubMed Link
(11) Gestwicki, J. E., Strong L. E., & Kiessling, L. L. (2000). Visualization of single multivalent receptor-ligand complexes by transmission electron microscopy. Angewandte Chemie, 39:4567-4570. PubMed Link
(10) Gordon, E. J., Gestwicki, J. E., Strong, L. E., & Kiessling, L. L. (2000). Synthesis of end-labeled multivalent ligands for exploring cell-surface-receptor-ligand interactions. Chemistry & Biology, 7:9-16. PubMed Link
(9) Gestwicki, J. E., Strong, L. E., & Kiessling, L. L. (2000). Tuning chemotactic responses with synthetic multivalent ligands. Chemistry & Biology, 7:583-591. PubMed Link
(8) Maki, N., Gestwicki, J. E., Lake, E. M., Kiessling, L. L., & Adler, J. (2000). Motility and chemotaxis of filamentous cells of Escherichia coli. Journal of Bacteriology, 182:4337-4342. PubMed Link
(7) Gestwicki, J. E., Lamanna, A. C., Harshey, R. M., McCarter, L. L., Kiessling, L. L., & Adler, J. (2000). Evolutionary conservation of methyl-accepting chemotaxis protein location in Bacteria and Archaea. Journal of Bacteriology, 182:6499-6502. PubMed Link
(6) Kiessling, L. L., Gestwicki, J. E., & Strong, L. E. (2000). Synthetic multivalent ligands in the exploration of cell-surface interactions. Current Opinion in Chemical Biology, 4:696-703.PubMed Link
(5) Kiessling, L. L., Strong, L. E., & Gestwicki, J. E. (2000). Principles for multivalent ligand design. Annual Reports in Medicinal Chemistry, 35:321-330.
(4) Hoag, K. A., Clise-Dwyer, K., Lim, Y.-H., Nashold, F. E., Gestwicki, J. E., Cancro, M. P., Hayes, C. E. (2000) A quantitative trait locus controlling peripheral B-cell deficiencies maps to the murine chromosome 15. Immunogenetics, 51:1210-1214.
(3) Kabza, K., Gestwicki, J. E., & McGrath, J. L. (2000). Contact angle goniometry as a tool for surface tension measurements of solids, using Zisman plot method - A physical chemistry experiment. Journal of Chemical Education, 77:63-65.
(2) Kabza, K. G., Chapados, B. R., Gestwicki, J. E., & McGrath, J. L. (2000). Microwave-induced esterification using heterogeneous acid catalyst in a low dielectric constant medium. Journal of Organic Chemistry, 65:1210-1214. PubMed Link
(1) Kabza, K. G., Gestwicki, J. E., McGrath, J. L., & Petrassi, H. M. (1996). Effect of microwave radiation on copper(II) 2,2'-bipyridyl-mediated hydrolysis of bis(p-nitrophenyl) phosphodiester and enzymatic hydrolysis of carbohydrates. Journal of Organic Chemistry, 61:9599-9602.
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