In the Gestwicki laboratory, we are interested in understanding how multi-protein complexes are formed, how they are regulated and how they integrate information. Our particular focus is on developing new chemical probes that can be used to perturb these systems - by either forcing new protein-protein interactions or blocking existing contacts. The twin goals of this work are to understanding the structure, function and regulation of multi-protein complexes, while also providing unique opportunities for the discovery of new drugs and drug targets. Because of urgent needs in human health, we have particular interest in applying our chemical tools to gain a deeper understanding of the underlying causes of neurodegenerative disorders, such as Alzheimer's disease.

Latest News

September 2009: Our joint manuscript with the Dickey Group has been accepted for publication at J. Neuroscience.

July 2009: Congratulations to Ashley Reinke and Paul Marinec on the acceptance of their manuscripts and to Matt Smith on being awarded a pre-doctoral fellowship from the Aging Training Grant.

June 2009: Ashley Reinke has received the Adam A. and Mary J. Christman Award, given to the most outstanding third-year student in Biological Chemistry. Also, Chris Evans' manuscript has been accepted for publication at Organic Letters and the Gestwicki Laboratory has been awarded a CAREER Development award from the NSF.

March 2009: Congratulations to Ashley Reinke, Chris Evans and Paul Marinec on receiving Rackham Travel Grants.

January 2009: Congratulations to Paul Marinec on the acceptance of his manuscript at Proc. Natl. Acad. Sci. and Srikanth Patury on the acceptance of his manuscript at Cell Biochem. Biophys..