In the Gestwicki laboratory, we are interested in understanding how multi-protein complexes are formed, how they are regulated and how they integrate information. Our particular focus is on developing new chemical probes that can be used to perturb these systems - by either forcing new protein-protein interactions or blocking existing contacts. The twin goals of this work are to understand the structure, function and regulation of multi-protein complexes, while also providing unique opportunities for the discovery of new drugs and drug targets. Because of urgent needs in human health, we have particular interest in applying our chemical tools to gain a deeper understanding of the underlying causes of neurodegenerative disorders, such as Alzheimer's disease.
Latest News
January 2012. Welcome new rotation students Zapporah Young and Robert Frick. Congratulations to Srikanth Patury on successfully defending his thesis!
