Our Research: The fundamental goal of our research is to understand and exploit the enzymes involved in natural product biosynthesis and bacterial resistance with the ultimate objective of developing novel biologically active compounds that target infectious diseases and malignant tumors. We are especially interested in two classes of compounds: the aminoglycoside antibiotics and the nonribosomal peptides. We focus on lung diseases (Tuberculosis), cancer, and Alzheimer's Disease. The research in our laboratory lies at the interface of biology, organic chemistry, and medicine. Tools and strategies from molecular biology, biochemistry, microbiology, and synthetic organic chemistry are key to our work.
The Garneau-Tsodikova lab welcomes Dr. Abdelrahman (Abdo) Mayhoub, a new postdoctoral fellow in the lab!
Congratulations to Joshua Bornstein on being awarded the Honors College Vanko Memorial Award !
Congratulations to Joshua Bornstein on receiving Highest Honors on his senior thesis on multi-functional drugs for Alzheimer's Disease !
Congratulations to Wenjing Chen on the successful defense of her PhD thesis (April 18, 2012). Congrats Dr. Chen !
Rachel Pricer officially joins the lab! Welcome Rachel!
Congratulations to Jacob Houghton on being awarded a Rackham Graduate Student Research Grant!
Congratulations to Keith Green and the Fridman lab members on the acceptance of their manuscript in Angew. Chem.!
Herzog, I.M.,† Green, K.D.,† Zrihen-Berkov, Y., Feldman, M. Vidavski, R.R., Eldar-Boock, A., Satchi-Fainaro, R., Eldar, A., Garneau-Tsodikova, S.*, & Fridman, M.* (2012). 6"-Thioether tobramycin analogues: Towards selective targeting of bacterial membranes, Angew. Chem., In press.
†Denotes equal contributionSylvie got an NSF CAREER Award ! Many thanks to NSF.
The Garneau-Tsodikova lab welcomes Rachel Pricer, a graduate student from the Chemical Biology Doctoral Program for a rotation in the lab!
Our structure of the Mycobacterium tuberculosis acetyltransferase aminoglycoside resistance enzyme Eis (PDB code: 3r1k), determined in collaboration with Oleg Tsodikov's lab, is the Molecule of the Month at the Protein Data Bank (PDB)!
Congratulations to Jacob Houghton and Tapan Biswas (from Oleg Tsodikov's lab) on the acceptance of their manuscript in Protein Science!
Biswas, T.,† Houghton, J.L.,† Garneau-Tsodikova, S.*, & Tsodikov, O.V.* (2012). The structural basis for substrate versatility of chloramphenicol acetyltransferase CATI, Protein Sci., 21(4), 520-530.
†Denotes equal contributionWe made the back cover of ChemMedChem (January 2012 first issue)! Congratulations to Keith Green and Wenjing Chen!
Click Image to Enlarge
The Garneau-Tsodikova lab would like to thank the Alzheimer's Art Quilt Initiative (AAQI) for their generous support of our research on drug development for Alzheimer's Disease!
To visit the AAQI webpage please go to: http://www.alzquilts.org/
The founder and executive director of AAQI, Ami Simms, and some members of her team (Debbie Chenail, AAQI treasurer; Ruth Langdon, AAQI volunteer; Pat Holly, AAQI quilt donor; and Sue Nickels, AAQI quilt donor) visited the Garneau-Tsodikova laboratory on December 19, 2011! They brought amazing quilts representative of the work that the AAQI does to raise money towards finding a cure for Alzheimer's Disease. Here are some pictures of their visit.
Thanks AAQI !
The Garneau-Tsodikova lab welcomes Athena Flecha, a rotation graduate student from the Medicinal Chemistry department!
Congratulations to Keith Green and Wenjing Chen on the acceptance of their manuscript in ChemMedChem!
Green, K.D., Chen, W., & Garneau-Tsodikova, S.* (2012). Identification and characterization of inhibitors of the aminoglycoside resistance acetyltransferase Eis from Mycobacterium tuberculosis, ChemMedChem, 7(1), 73-77.
The Garneau-Tsodikova lab thanks the Firland Foundation for support of our work on tuberculosis!
Congratulations to Todd Eckroat for his successful candidacy exam!
The Garneau-Tsodikova lab welcomes Rebecca Reed, a graduate student from the Chemical Biology Doctoral Program for the Summer!
Congratulations to Jacob Houghton for being awarded the prestigious 2011 AFPE Pre-Doctoral Fellowship!
The Garneau-Tsodikova lab welcomes Fulla Abdul-Jabbar, a Perrigo 2011 Fellow! Congratulations Fulla for being selected for the prestigious Perrigo Fellowship!
Congratulations to Wenjing Chen and Tapan Biswas (from Oleg Tsodikov's lab) on the acceptance of their manuscript in PNAS !
Chen, W.,† Biswas, T.,† Porter, V.R., Tsodikov, O.V.,* & Garneau-Tsodikova, S.* (2011). Unusual regioversatility of acetyltransferase Eis, a cause of drug resistance in XDR-TB, Proc. Nat. Acad. Sci., U.S.A., 108(24), 9804-9808. PubMed Link
†Denotes equal contribution
This article is featured in News:
Life Sciences Institute Link LSI
University of Michigan News Service UM News
UofM Health.org UM Health.org
myScience myScience
Malnutrition, malaria and the mycobacterium Malnutrition
ANPRON ANPRON
BioSpace BioSpace
The Cutting Edge The Cutting Edge
CBS Detroit CBS Detroit
We made the inside cover of Org. Biomol. Chem. (May 2011, Issue 11)! Congratulations to Keith Green and the Fridman lab members!
Click Image to Enlarge
We made the cover of MedChemComm (May 2011, Issue 5)! Congratulations to Joshua Bornstein, Todd Eckroat, Jacob Houghton, Christopher Jones, and Keith Green!
Click Image to Enlarge
Congratulations to Keith Green and Wenjing Chen on the acceptance of their manuscript in Antimicrob. Agents Chemother.!
Green, K.D., Chen, W., & Garneau-Tsodikova, S.* (2011). Effects of altering aminoglycoside structures on bacterial resistance enzyme activities, Antimicrob. Agents Chemother., 55(7), 3207-3213.
The Garneau-Tsodikova lab welcomes Chris Jones, Chemical Biology Doctoral Student!
Congratulations to Sylvia Waldron for being awarded a UROP fellowship for Summer 2011!
Congratulations to Olga Zolova, Ahmed Mady, and the Lombó lab members on the acceptance of their manuscript in Molec. Biosystems!
Mady, A.S.A.,† Zolova, O.E.,† Álvarez San Millán, M., Villamizar, G., de la Calle, F., Lombó, F., & Garneau-Tsodikova, S.* (2011). Characterization of TioQ, a type II thioesterase from the thiocoraline biosynthetic cluster, Molec. Biosystems, 7(6), 1999-2011.
†Denotes equal contributionCongratulations to Joshua Bornstein, Todd Eckroat, Jacob Houghton, Chris Jones, and Keith Green on the acceptance of their manuscript in MedChemComm!
Bornstein, J.J., Eckroat, T.J., Houghton, J.L., Jones, C.K., Green, K.D., & Garneau-Tsodikova, S.* (2011). Tacrine-mefenamic acid hybrids for inhibition of acetylcholinesterase, MedChemComm, 2(5), 406-412.
Congratulations to Keith Green and the Fridman lab members on the acceptance of their manuscript in Org. Biomol. Chem.!
Shaul, P.,† Green, K.D.,† Rutenberg, R., Kramer, M., Berkov-Zrihen, Y., Breiner-Goldstein, E., Garneau-Tsodikova, S.,* & Fridman, M.* (2011). Assessment of 6'- and 6'"-N-acylation of aminoglycosides as a strategy to overcome bacterial resistance, Org. Biomol. Chem., 9(11), 4057-4063.
†Denotes equal contribution; *Denotes co-corresponding authorsThis article was selected as an OBC Hot article and was featured in
OBC Blog Link OBC Blog
Congratulations to Keith Green, Olga Zolova, and Jacob Houghton on the acceptance of their manuscript in Biochem. Biophys. Res. Comm.!
Porter, V.R.,† Green, K.D.,† Zolova, O.E., Houghton, J.L., & Garneau-Tsodikova, S.* (2010). Dissecting the cosubstrate structure requirements of the Staphylococcus aureus aminoglycoside resistance enzyme ANT(4'), Biochem. Biophys, Res. Comm., 403, 85-90.
†Denotes equal contributionThe Garneau-Tsodikova lab welcomes Christopher Jones, Chemical Biology graduate rotation student!
Congratulations to Jacob Houghton for being awarded a Rackham Travel Grant to attend the 240th ACS meeting in Boston!
Congratulations to Keith Green and Yaru Zhang on the acceptance of their manuscript in Biochemistry!
Green, K.D., Porter, V.R., Zhang, Y., & Garneau-Tsodikova, S.* (2010). Redesign of cosubstrate specificity and identification of important residues for substrate binding to hChAT, Biochemistry, In press.
Congratulations to Olga Zolova and Ahmed Mady on the acceptance of their manuscript in Biopolymers!
Zolova, O.E.,† Mady, A.S.A.,† & Garneau-Tsodikova, S.* (2010). Recent developments in bisintercalator natural products, Biopolymers, 93(9), 777-790. PubMed Link
†Denotes equal contribution
The Garneau-Tsodikova lab would like to welcome our new lab member Todd Eckroat, graduate student in the Medicinal Chemistry department!
Congratulations to Jacob Houghton, Keith Green, and Wenjing Chen on the acceptance of their manuscript in ChemBioChem!
Houghton, J.L., Green, K.D., Chen, W., & Garneau-Tsodikova, S.* (2010). The future of aminoglycosides: The end or renaissance, ChemBioChem, 11, 880-902.
This article is featured as the Editor's Choice: Spotlights in
ChemPubSoc Europe Link ChemPubSoc Europe
This article is highlighted in
Société Chimique de France Link Société Chimique de France
Congratulations to Joshua Bornstein for being awarded a 2010 Summer Undergraduate Research Fellowship from the Chemistry Department at the University of Michigan!
Congratulations to Olga Zolova and Tapan Biswas (from Oleg Tsodikov's lab) on the acceptance of their manuscript in J. Mol. Biol.!
Biswas, T.,† Zolova, O.E.,† Lombó, F., de la Calle, F., Salas, J.A., Tsodikov, O.V., & Garneau-Tsodikova, S. (2010). A new scaffold of an old protein fold ensures binding to the bisintercalator thiocoraline, J. Mol. Biol., 397, 495-507.
†Denotes equal contribution
We made the cover of ChemBioChem (January 2010 first issue)! Congratulations to Keith Green, Wenjing Chen, and Jacob Houghton!
Click Image to Enlarge
This article is featured in several News:
Futurity Link Futurity
Discovery Buzz Link Discovery Buzz
Physorg.com Link Physorg.com
Insciences Organisation Link Insciences
Drugs Reviews Link Drugs Reviews
Microbe world Link Microbe world
Lab News Daily Link Lab News Daily
University of Michigan (News Service Gateway, Today's Campus Online, Health Canal, and UM Record Online) Link News Service Gateway - Link Today's Campus Online - Link Health Canal - Link Record Online
Life Sciences Institute Link LSI
The Science Coalition Link The Science Coalition
Great Lakes IT Report Link Great Lakes IT Report
HealthCanal.com Link HealthCanal.com
Explore LSI Link Explore LSI
Curiosidades de la Microbiologia Link Curiosidades de la Microbiologia
Congratulations to Jacob Houghton on being awarded a US-Israel Binational Science Foundation (BSF) 2010 Travel Grant!
The Garneau-Tsodikova lab welcomes Ahmed Samir Mady, Graduate Visiting Student from the University of Utrecht (The Netherlands)!
Congratulations to Keith Green, Wenjing Chen, and Jacob Houghton on the acceptance of their manuscript in ChemBioChem!
Green, K.D., Chen, W., Houghton, J.L., Fridman, M., & Garneau-Tsodikova, S. (2010). Exploring the Substrate Promiscuity of Drug-Modifying Enzymes for the Chemoenzymatic Generation of N-Acylated Aminoglycosides, ChemBioChem, 11(1), 119-126.
The Garneau-Tsodikova lab welcomes Hao Xu and Todd Eckroat, Medicinal Chemistry graduate rotation students!
The Garneau-Tsodikova lab welcomes Yaru Zhang and Byung Chul Kim, Chemical Biology graduate rotation students!
The Garneau-Tsodikova lab thanks the United States - Israel Binational Science Foundation (BSF) for a Young Investigator Grant in collaboration with Dr. Micha Fridman (Tel Aviv University, Israel)!
Congratulations to Jacob Houghton for being awarded an ACS predoctoral fellowship by the division of Medicinal Chemistry for the 2009-10 academic year sponsored by Eli Lilly!
Congratulations to Keith Green on the acceptance of his manuscript in ChemBioChem!
Green, K.D., Fridman, M., & Garneau-Tsodikova, S. (2009). hChAT: a tool for the chemoenzymatic generation of potential acetyl/butyrylcholinesterase inhibitors, ChemBioChem,10(13), 2191-2194.
Congratulations to Jacob Houghton for his successful candidacy exam!
The Garneau-Tsodikova lab welcomes Kathryn Morrison, Medicinal Chemistry Graduate Summer Institute student!
The Garneau-Tsodikova lab welcomes Derik Scribner, REU student!
Congratulations to Caitlin O'Gara for being awarded a 2009 WISE Summer Undergraduate Research Fellowship at the University of Michigan!
The Garneau-Tsodikova lab welcomes Joshua Bornstein and Caitlin O'Gara!
Congratulations to Wenjing Chen for her successful candidacy exam!
The Garneau-Tsodikova lab thanks the Horace H. Rackham School of Graduate Studies at the University of Michigan for a Spring/Summer Research Grant!
Congratulations to Yefim Zaltsman for being awarded a 2009 Summer Undergraduate Research Fellowship from the Chemistry Department at the University of Michigan!
The Garneau-Tsodikova lab would like to welcome our new lab member Dr. Keith D. Green!
The Garneau-Tsodikova lab would like to welcome our new lab members Wenjing Chen (Chemical Biology) and Jake Houghton (Medicinal Chemistry)!
