Research interests in the Carroll group span the disciplines of chemistry and biology with an emphasis on studies of sulfur metabolism pertinent to disease states. Our lab focuses on the development of novel tools to study oxidative posttranslational modifications of cysteine thiols, profiling changes in protein oxidation associated with cancer, neurodegeneration, and diabetes, and exploiting this information for development of diagnostic and therapeutic approaches. In addition, our group investigates sulfur pathways that are essential for infection and long-term survival of pathogens such as Mycobacterium tuberculosis.

Latest News

October 2009

• Read the article on "Cysteine Oxidation" and research in the Carroll lab in the Oct 5, 2009 issue of Chemical & Engineering News. 

• Congratulations to Stephen Leonard on the acceptance of his manuscript in Science.

September 2009

• Congratulations to Candice Paulsen on her appointment to the Chemistry & Biology Interface Training Grant. 

August 2009

• Congratulations to Devayani Bhave and Candice Paulsen for being awarded a travel grant in recognition of their poster presentations at the Vaughan Symposium.

• Congratulations to Young Ho Seo on the acceptance of his manuscript in PNAS. 

Seo, Y. H. & Carroll, K. S. (2009). Profiling Protein Thiol Oxidation in Tumor Cells Using Sulfenic Acid-Specific Antibodies. Proc. Natl. Acad. Sci., 106: 16163-68. PDF | Press Release

• Congratulations to Stephen Leonard and Khalilah Reddie on the acceptance of their manuscript in ACS Chemical Biology.

Leonard, S. E.*, Reddie, K. G.* & Carroll, K. S. (2009). Mining the Thiol Proteome for Sulfenic Acid Modifications Reveals New Targets for Oxidation in Cells. ACS Chem. Bio., 4: 783-99. PDF | Press Release *Co-first authors. 

July 2009

• Congratulations to Jiyoung Hong and Devayani Bhave on the acceptance of their manuscript in the Journal of Medicinal Chemistry.

Hong, J. A., Bhave, D. P. & Carroll, K. S. (2009). Identification of Critical Ligand Binding Determinants in Mycobacterium tuberculosis Adenosine-5′-phosphosulfate Reductase. J. Med. Chem., 52: 5485-95. PDF

January 2009

• Congratulations to Candice Paulsen on the acceptance of her manuscript in Chemistry & Biology. 

Paulsen C. E. & Carroll, K. S. (2009). Chemical dissection of an essential redox switch in yeast. Chemistry & Biology, 16: 217-225. PDF