Victors for Discovery

Victors for Discovery:
Biomedicine at Michigan

LSI Annual Symposium     May 14-15, 2014

  • Two days of lectures and discussions with national leaders in pharmaceutical development, government agencies and patient care—who all spent time on U-M faculty
    Panel discussions on the future of biomedical research and drug discovery in the 21st century

Palmer Commons
Forum Hall and Great Lakes Room
100 Washtenaw Avenue
Ann Arbor, MI 48109

Free and open to the public

 

Day 1: Wednesday, May 14

8:30 am   Welcome
Alan Saltiel, PhD, Mary Sue Coleman Director of the Life Sciences Institute

8:35 am   Introduction of the Mary Sue and Kenneth Coleman Life Sciences Lecturer
Mary Sue Coleman, PhD, President, University of Michigan

8:45 am   Mary Sue and Kenneth Coleman Life Sciences Lecturer:
"A New Family of Kinases Important in Bone and Teeth Formation," Jack Dixon, PhD
Professor, Pharmacology, Cellular and Molecular Medicine, Chemistry and Biochemistry, University of California, San Diego

Session 1
Moderated by Michael S. Parmacek, MD
Chair, Department of Medicine; Director, Penn Cardiovascular Institute; Herbert C. Rorer Professor of Medical Sciences, University of Pennsylvania

10:05 am   "The Hippo-YAP Pathway in Organ Size Control and Tumorigenesis," Kun-Liang Guan, PhD
Professor, Pharmacology, University of California, San Diego

10:40 am   "How Does Protein Misfolding in the Endoplasmic Reticulum Cause Cell Death?,"  Randal J. Kaufman, PhD
Director, Degenerative Diseases Program; Sanford|Burnham Medical Research Institute

11:15 am   "Nitric Oxide in Biology and Medicine," Michael A. Marletta, PhD
President and Chief Executive Officer, Cecil H. and Ida M. Green Chair in Chemistry, Professor, Department of Chemistry, Scripps Research Institute

Session 2
Moderated by Beverly S. Mitchell, MD
George E. Becker Professor of Medicine; Director, Stanford Cancer Institute

1:15 pm   "Down Syndrome and Cancer: the Ying and Yang of Stem Cells," Michael F. Clarke, MD
Karel and Avice Beekhuis Professorship in Cancer Biology, Associate Director, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Professor of Medicine (Oncology), Stanford University 

1:50 pm   "Ubiquitin Modification in Cancer Pathogenesis," Vishva Dixit, MD
Vice President, Physiological Chemistry, Genentech, Inc.

2:30 pm   "The Regulation of Stem Cell Self-Renewal," Sean J. Morrison, PhD
Director, Children’s Research Institute; Mary McDermott Cook Chair in Pediatric Genetics; Investigator, Howard Hughes Medical Institute; University of Texas Southwestern Medical Center

3:10 pm   "Inherited Susceptibility in Patients and Populations: Genetics is not Destiny," Stephen B. Gruber, MD, PhD, MPH
Director, USC Norris Comprehensive Cancer Center; Professor, Medicine and  H. Leslie Hoffman and Elaine S. Hoffman Chair, Cancer Research, University of Southern California

4:10 pm Panel Discussion

"The Future of Biomedical Research"

Moderated by David Ginsburg, MD, James V. Neel Distinguished University Professor of Internal Medicine and Human Genetics, and Pediatrics and Communicable Diseases; Investigator, Howard Hughes Medical Institute; Research Professor, Life Sciences Institute, University of Michigan Medical School

Introductory Talk: "The Past is Prologue: You Ain’t Seen Nothin’ Yet"
Francis S. Collins, MD, PhD
Director, National Institutes of Health

Panelists:

  • Jack Dixon, PhD
    Professor, Pharmacology, Cellular and Molecular Medicine, Chemistry and Biochemistry, University of California, San Diego             
  • William N. Kelley, MD
    Professor, Medicine, University of Pennsylvania
  • Michael A. Marletta, PhD
    President and Chief Executive Officer, Cecil H. and Ida M. Green Chair in Chemistry, Professor, Department of Chemistry, Scripps Research Institute
  • Elizabeth G. Nabel M.D.
    President, Brigham and Women’s Hospital; Professor of Medicine, Harvard Medical School

5:55 pm   Closing remarks
Alan Saltiel, PhD, Mary Sue Coleman Director of the Life Sciences Institute

6:00-6:45 pm   Public Reception

 

Day 2: Thursday, May 15

8:30 am   Welcome
David Ginsburg, MD, James V. Neel Distinguished University Professor of Internal Medicine and Human Genetics, and Pediatrics and Communicable Diseases; Investigator, Howard Hughes Medical Institute; Research Professor, Life Sciences Institute, University of Michigan Medical School

Session 3
Moderated by Stephen G. Emerson, MD, PhD
Clyde Wu Professor of Immunology and Medicine; Professor, Microbiology and Immunology; Director, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center

8:40 am   "Pathways for Immune Tolerance in Transplantation," Laurence A. Turka, MD
Harold and Ellen Danser Professor of Surgery, Harvard Medical School; Co-Director, Transplantation Biology Research Center, Massachusetts General Hospital; Deputy Director, Immune Tolerance Network

9:15 am   "Is Gene Therapy Ready for Prime Time?," James M. Wilson, MD, PhD
Director, Gene Therapy Program; Research Director, Center for Orphan Disease Research and Therapy; Professor, Department of Pathology & Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania                                                                 

9:55 am   "The Epigenetic Basis of Human Cancer," Andrew P. Feinberg, MD, MPH
Gilman Scholar, Professor of Medicine, Oncology, Molecular Biology/Genetics, and Biostatistics; Director, Center for Epigenetics, Johns Hopkins University School of Medicine

11:00 am Panel Discussion

"Drug Discovery and Development in the 21st Century"

Moderated by Alan Saltiel, PhD, Mary Sue Coleman Director of the Life Sciences Institute

Introductory Talk: "Making New Medicines: New Approaches to an Old Challenge," Tachi Yamada, MD
Chief Medical & Scientific Officer, Executive Vice President & Board Member, Takeda Pharmaceuticals                           

Panelists:

  • Vishva Dixit, MD
    Vice President, Physiological Chemistry, Genentech, Inc.
  • John B. Lowe, MD
    Senior Director, Research Pathology Department, Genentech, Inc.
  • Gary J. Nabel, MD, PhD
    Chief Scientific Officer and Senior Vice President, Sanofi
  • Craig B. Thompson, MD
    President and Chief Executive Officer, Memorial Sloan Kettering Cancer Center
  • Barbara Weber, MD
    Senior Vice President and Global Head, Oncology Translational Medicine, Novartis Oncology

12:45 pm   Closing Remarks
David Ginsburg, MD, James V. Neel Distinguished University Professor of Internal Medicine and Human Genetics, and Pediatrics and Communicable Diseases; Investigator, Howard Hughes Medical Institute; Research Professor, Life Sciences Institute, University of Michigan Medical School

—Apr 1, 2014