In addition to the Center for Chemical Genomics, Center for Structural Biology and Center for the Discovery of New Medicines, the LSI houses a number of scientific cores available to researchers from throughout the university.
DNA Sequencing Core
The University of Michigan's DNA Sequencing Core provides U-M investigators access to automated DNA sequencing technology on a recharge basis. The Core processes samples primarily on a pair of ABI Model 3730 sequencers, with a Model 3700 occasionally used for backup capacity. Samples are typically processed in 2 business days, and yield 700-900 nucleotides of high-quality DNA sequence data. It is located on the third floor of LSI, room 3266.
Flow Cytometry Core
The Flow Cytometry Core laboratory provides flow cytometry instrumentation and expertise to University of Michigan investigators—and the surrounding biotech community—in a broad range of basic and medical science disciplines. Samples are prepared by individual investigators, who then deliver samples to the Core for flow cytometric analysis or cell sorting. The Core also provides assistance in grant and publication preparation, publication-quality graphics, and development of experimental designs. It is located on the third floor of LSI, room 3222.
Email: davadams at med.umich.edu
The first floor of the Life Sciences Institute is devoted to a state-of-the-art 36,000 square foot vivarium for small animals and fish. Facilities include ample quarantine areas and procedure rooms that eliminate the need to carry animals throughout the building. It is directed by Board Certified Laboratory Animal Medicine Veterinarians and staffed with certified laboratory animal technicians and is accredited by the Association for Assessment and Accreditation of Laboratory Animal Care (AAALAC).
Housed in the third floor of the LSI, the Varian 400 MHz NMR and 600 MHz NMR are modern, high-end active-shielded instruments suitable for biomolecule structural analysis. There is also a Protasis CapNMR Probe, which allows unprecedented reduction in sample volume for NMR analysis, in turn reducing solvent usage and permits detection of small quantities of organic molecules. This system provides rapid structural determination of compounds from HPLC fraction high throughput.