History

History of small molecule and siRNA screening capabilities

The High Throughput Screening (HTS) facility is a central component of the Center for Chemical Genomics (CCG). This core facility is designed to assist academic researchers in carrying out high-throughput screens of chemical libraries and to identify new tools for biological research.

The CCG screening facility is built around modular workstations, and assays are generally carried out in 384-well plates. The CCG compound collection is continuously growing and is available for screening. The facility will also provide access to compound libraries and training in the use of some instruments, such as liquid handling equipment and plate readers. Staff members run all complex automation for screens. Data from all screens performed by the HTS laboratory are collected and stored in a non-public, central database to allow researchers to rapidly evaluate and compare results of their screens.

Started as the Michigan Drug Exploration Initiative by a small group of faculty in the Medical School and the College of Pharmacy in 2002, the effort grew with the addition of a small chemical library and liquid handling robot funded by the Medical School, the Office of the Vice President for Research, and the Cancer Center. In 2004 the initiative joined the CCG as part of the Life Sciences Institute to form a core facility within the University of Michigan for high-throughput screening and a chemical tool for academic drug discovery. In 2004 and 2005, the UM Medical School Endowment for Basic Science provided major support to the CCG operations and infrastructure.

The HTS facility is located in the Center for Chemical Genomics, Room 3338 Life Sciences Institute, 210 Washtenaw Ave., Ann Arbor, MI 48104-2216. For more information, please contact the HTS Director, mjlarsen [at] umich.edu (Martha Larsen).

Journals

For more information on screening methods and technologies, we recommend the following journals. They would also be appropriate selections for publishing your methods.

Journal of Biomolecular Screening

Assay and Drug Development Technologies

Combinatorial Chemistry and High-Throughput Screening

International Journal of High-throughput Screening

Analytical Biochemistry

Drug Discovery Today

Nature Reviews Drug Discovery

Current Drug Discovery Technologies

Drug Discoveries Today: Technologies