Narayan Lab Publications

Narayan, A. R. N.; Jiménez-Osés, G.; Liu, P.; Negretti, S.; Zhao, W.; Ramabhadr, R. O.; Furan, L.; Li, Z.; Yang, Y.-F.; Gilbert, M.; Podust, L. M.; Montgomery, J.; Houk, K. N.; Sherman, D. H.  “Enzymatic Hydroxylation of an Unactivated Methylene C–H Bond Guided by Molecular Dynamics Simulations” Nature Chem. 2015, DOI: 10.1038/nchem.2285.
 
Dutta, S.; Whicher, J. R.; Hansen, D. A.; Hale, W. A.; Chemler, J. A.; Narayan, A. R. N.; Hakansson, K.; Sherman, D. H.; Smith, J. L.; Skiniotis, G. “Structure of a modular polyketide synthase” Nature 2014, 510, 512-517.
 
Whicher, J. R.; Dutta, S.; Hansen, D. A.; Hale, W. A.; Chemler, J. A.; Narayan, A. R. N.; Hakansson, K.; Sherman, D. H.; Smith, J. L.; Skiniotis, G. “Structural rearrangements of a PKS module during its catalytic cycle” Nature 2014, 510, 560-564.
 
Negretti, S.*; Narayan, A. R. H.*; Chiou, K. C.; Kells, P. M.; Stachowski, J. L.; Hansen, D. A.; Podust, L. M.; Montgomery, J.; Sherman, D. H. “Directing group-controlled regioselectivity in an enzymatic C-H bond oxygenation” J. Am. Chem. Soc. 2014, 136, 4901-4904. *Denotes equal contribution
  
Heller, S. T.; Kiho, T.; Narayan, A. R. H.; Sarpong, R. “Protic Solvent Mediated Cycloisomerization of Quinoline and Isoquinoline Propargylic Carbinols: Syntheses of (±)-3-Demethoxyerythratidinone and (±)-Cocculidine” Angew. Chem. Int. Ed. 2013, 52, 11129-11133.
 
Hansen, D. H.; Rath, C. M.; Eisman, E. B.; Narayan, A. R. H.; Kittendorf, J. D.; Mortison, J. D.; Yoon, Y. J.; Sherman, D. H. “Biocatalytic Synthesis of Pikromycin, Methymycin, Neomethymycin, Novamethymycin, and Ketomethymycin” J. Am. Chem. Soc. 2013, 135, 11232-11238.
 
Narayan, A. R. H.; Sherman, D. H. “Re-engineering nature’s catalysts” Science 2013, 339, 283-284.
 
Hardin Narayan, A. R.; Sarpong, R. "Indolizinones as Synthetic Scaffolds: Fundamental Reactivity and the Relay of Stereochemical Information" Org. Biomol. Chem. 2012, 10, 70-78.
 
Hardin Narayan, A. R.; Sarpong, R. “Remarkable Facilitation of Hetero-Cycloisomerizations with Water and Other Polar Protic Solvents: Metal-Free Synthesis of Indolizines” Green Chem. 2010, 10, 1556-1559.
 
Hardin Narayan, A. R.; Simmons, E. R.; Sarpong, R. “Synthetic strategies toward the cortistatin family of natural products” Eur. J. Org. Chem. 2010, 3553-3567.
 
Simmons, E. M.; Hardin, A. R.; Guo, X.; Sarpong, R. "Formal total synthesis of (±)-cortistatin A" Tetrahedron 2010, 66, 4696-4700.
 
Simmons, E. M.; Hardin, A. R.; Guo, X.; Sarpong, R. “Rapid Construction of the Cortistatin Pentacyclic Core” Angew. Chem. Int. Ed. 2008, 47, 6650 – 6653.
 
Hardin, A. R.; Sarpong, R. "Electronic Effects in the Pt-Catalyzed Cycloisomerization of Propargylic Esters: Synthesis of 2,3-Disubstituted Indolizines as a Mechanistic Probe" Org. Lett. 2007, 9, 4547-4550.
 
Adams, J.; Hardin, A. R.; Vounatsos, F. “Microwave-Assisted Synthesis of New Polysubstituted Dienaminoesters and Their Cyclization to 3-Bromo-2(1H)-Pyridinones” J. Org. Chem. 2006, 71, 9895-9898.
 
Hay, M.; Hardin, A. R.; Wolfe, J. P. “Palladium-Catalyzed Synthesis of Tetrahydrofurans from γ-Hydroxy Terminal Alkenes:  Scope, Limitations, and Stereoselectivity” J. Org. Chem. 2005, 70, 3099-3107.